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Items: 1 to 20 of 58

1.

Identification of Celastramycin as a Novel Therapeutic Agent for Pulmonary Arterial Hypertension-High-throughput Screening of 5,562 Compounds.

Kurosawa R, Satoh K, Kikuchi N, Kikuchi H, Saigusa D, Al-Mamun EA, Siddique MAH, Omura J, Satoh T, Sunamura S, Nogi M, Numano K, Miyata S, Uruno A, Kano K, Matsumoto Y, Doi T, Aoki J, Oshima Y, Yamamoto M, Shimokawa H.

Circ Res. 2019 Jun 14. doi: 10.1161/CIRCRESAHA.119.315229. [Epub ahead of print]

PMID:
31195886
2.

Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease.

Kikuchi K, Saigusa D, Kanemitsu Y, Matsumoto Y, Thanai P, Suzuki N, Mise K, Yamaguchi H, Nakamura T, Asaji K, Mukawa C, Tsukamoto H, Sato T, Oikawa Y, Iwasaki T, Oe Y, Tsukimi T, Fukuda NN, Ho HJ, Nanto-Hara F, Ogura J, Saito R, Nagao S, Ohsaki Y, Shimada S, Suzuki T, Toyohara T, Mishima E, Shima H, Akiyama Y, Akiyama Y, Ichijo M, Matsuhashi T, Matsuo A, Ogata Y, Yang CC, Suzuki C, Breeggemann MC, Heymann J, Shimizu M, Ogawa S, Takahashi N, Suzuki T, Owada Y, Kure S, Mano N, Soga T, Wada T, Kopp JB, Fukuda S, Hozawa A, Yamamoto M, Ito S, Wada J, Tomioka Y, Abe T.

Nat Commun. 2019 Apr 23;10(1):1835. doi: 10.1038/s41467-019-09735-4.

3.

Nrf2 activation in myeloid cells and endothelial cells differentially mitigates sickle cell disease pathology in mice.

Keleku-Lukwete N, Suzuki M, Panda H, Otsuki A, Katsuoka F, Saito R, Saigusa D, Uruno A, Yamamoto M.

Blood Adv. 2019 Apr 23;3(8):1285-1297. doi: 10.1182/bloodadvances.2018017574. Erratum in: Blood Adv. 2019 Jun 11;3(11):1701.

4.

Measurement of the Spatial Distribution of S1P in Small Quantities of Tissues: Development and Application of a Highly Sensitive LC-MS/MS Method Combined with Laser Microdissection.

Wang J, Kano K, Saigusa D, Aoki J.

Mass Spectrom (Tokyo). 2019;8(1):A0072. doi: 10.5702/massspectrometry.A0072. Epub 2019 Feb 14.

5.

Maternity Log study: a longitudinal lifelog monitoring and multiomics analysis for the early prediction of complicated pregnancy.

Sugawara J, Ochi D, Yamashita R, Yamauchi T, Saigusa D, Wagata M, Obara T, Ishikuro M, Tsunemoto Y, Harada Y, Shibata T, Mimori T, Kawashima J, Katsuoka F, Igarashi-Takai T, Ogishima S, Metoki H, Hashizume H, Fuse N, Minegishi N, Koshiba S, Tanabe O, Kuriyama S, Kinoshita K, Kure S, Yaegashi N, Yamamoto M, Hiyama S, Nagasaki M.

BMJ Open. 2019 Feb 19;9(2):e025939. doi: 10.1136/bmjopen-2018-025939.

6.

Value of global metabolomics in association with diagnosis and clinicopathological factors of renal cell carcinoma.

Sato T, Kawasaki Y, Maekawa M, Takasaki S, Saigusa D, Ota H, Shimada S, Yamashita S, Mitsuzuka K, Yamaguchi H, Ito A, Kinoshita K, Koshiba S, Mano N, Arai Y.

Int J Cancer. 2019 Jul 15;145(2):484-493. doi: 10.1002/ijc.32115. Epub 2019 Jan 24.

PMID:
30628065
7.

Lactate dehydrogenase C is required for the protein expression of a sperm-specific isoform of lactate dehydrogenase A.

Dodo M, Kitamura H, Shima H, Saigusa D, Wati SM, Ota N, Katsuoka F, Chiba H, Okae H, Arima T, Igarashi K, Koseki T, Sekine H, Motohashi H.

J Biochem. 2019 Apr 1;165(4):323-334. doi: 10.1093/jb/mvy108.

PMID:
30590713
8.

Genome analyses for the Tohoku Medical Megabank Project towards establishment of personalized healthcare.

Yasuda J, Kinoshita K, Katsuoka F, Danjoh I, Sakurai-Yageta M, Motoike IN, Kuroki Y, Saito S, Kojima K, Shirota M, Saigusa D, Otsuki A, Kawashima J, Yamaguchi-Kabata Y, Tadaka S, Aoki Y, Mimori T, Kumada K, Inoue J, Makino S, Kuriki M, Fuse N, Koshiba S, Tanabe O, Nagasaki M, Tamiya G, Shimizu R, Takai-Igarashi T, Ogishima S, Hozawa A, Kuriyama S, Sugawara J, Tsuboi A, Kiyomoto H, Ishii T, Tomita H, Minegishi N, Suzuki Y, Suzuki K, Kawame H, Tanaka H, Taki Y, Yaegashi N, Kure S, Nagami F; Tohoku Medical Megabank Project Study Group, Kosaki K, Sutoh Y, Hachiya T, Shimizu A, Sasaki M, Yamamoto M.

J Biochem. 2019 Feb 1;165(2):139-158. doi: 10.1093/jb/mvy096.

PMID:
30452759
9.

Functional characterization of 50 CYP2D6 allelic variants by assessing primaquine 5-hydroxylation.

Saito T, Gutiérrez Rico EM, Kikuchi A, Kaneko A, Kumondai M, Akai F, Saigusa D, Oda A, Hirasawa N, Hiratsuka M.

Drug Metab Pharmacokinet. 2018 Dec;33(6):250-257. doi: 10.1016/j.dmpk.2018.08.004. Epub 2018 Aug 25.

PMID:
30366777
10.

Functional characterization of 40 CYP2B6 allelic variants by assessing efavirenz 8-hydroxylation.

Watanabe T, Saito T, Rico EMG, Hishinuma E, Kumondai M, Maekawa M, Oda A, Saigusa D, Saito S, Yasuda J, Nagasaki M, Minegishi N, Yamamoto M, Yamaguchi H, Mano N, Hirasawa N, Hiratsuka M.

Biochem Pharmacol. 2018 Oct;156:420-430. doi: 10.1016/j.bcp.2018.09.010. Epub 2018 Sep 8.

PMID:
30201214
11.

Metabolomic changes in the mouse retina after optic nerve injury.

Sato K, Saigusa D, Saito R, Fujioka A, Nakagawa Y, Nishiguchi KM, Kokubun T, Motoike IN, Maruyama K, Omodaka K, Shiga Y, Uruno A, Koshiba S, Yamamoto M, Nakazawa T.

Sci Rep. 2018 Aug 9;8(1):11930. doi: 10.1038/s41598-018-30464-z.

12.

Metabolomic Analysis of Mouse Brain after a Transient Middle Cerebral Artery Occlusion by Mass Spectrometry Imaging.

Abe T, Niizuma K, Kanoke A, Saigusa D, Saito R, Uruno A, Fujimura M, Yamamoto M, Tominaga T.

Neurol Med Chir (Tokyo). 2018 Sep 15;58(9):384-392. doi: 10.2176/nmc.oa.2018-0054. Epub 2018 Aug 3.

13.

Intracellular S1P Levels Dictate Fate of Different Regions of the Hippocampus following Transient Global Cerebral Ischemia.

Rashad S, Niizuma K, Saigusa D, Han X, Sato-Maeda M, Saito R, Uruno A, Fujimura M, Ikawa S, Yamamoto M, Tominaga T.

Neuroscience. 2018 Aug 1;384:188-202. doi: 10.1016/j.neuroscience.2018.05.015. Epub 2018 May 19.

PMID:
29782904
14.

Detection of novel metabolite for roxadustat doping by global metabolomics.

Saigusa D, Suzuki N, Matsumoto Y, Umeda K, Tomioka Y, Koshiba S, Yamamoto M.

J Biochem. 2018 Jun 1;163(6):e1. doi: 10.1093/jb/mvy036. No abstract available.

PMID:
29771375
15.

Omics research project on prospective cohort studies from the Tohoku Medical Megabank Project.

Koshiba S, Motoike I, Saigusa D, Inoue J, Shirota M, Katoh Y, Katsuoka F, Danjoh I, Hozawa A, Kuriyama S, Minegishi N, Nagasaki M, Takai-Igarashi T, Ogishima S, Fuse N, Kure S, Tamiya G, Tanabe O, Yasuda J, Kinoshita K, Yamamoto M.

Genes Cells. 2018 Jun;23(6):406-417. doi: 10.1111/gtc.12588. Epub 2018 Apr 27. Review.

16.

Vitamin B3 Nicotinamide: A Promising Candidate for Treating Preeclampsia and Improving Fetal Growth.

Takahashi N, Li F, Fushima T, Oyanagi G, Sato E, Oe Y, Sekimoto A, Saigusa D, Sato H, Ito S.

Tohoku J Exp Med. 2018 Mar;244(3):243-248. doi: 10.1620/tjem.244.243. Review.

17.

Liver Zonation Index of Drug Transporter and Metabolizing Enzyme Protein Expressions in Mouse Liver Acinus.

Tachikawa M, Sumiyoshiya Y, Saigusa D, Sasaki K, Watanabe M, Uchida Y, Terasaki T.

Drug Metab Dispos. 2018 May;46(5):610-618. doi: 10.1124/dmd.117.079244. Epub 2018 Mar 5.

PMID:
29506983
18.

Detection of novel metabolite for Roxadustat doping by global metabolomics.

Saigusa D, Suzuki N, Matsumoto Y, Umeda K, Tomioka Y, Koshiba S, Yamamoto M.

J Biochem. 2018 Feb 9. doi: 10.1093/jb/mvy028. [Epub ahead of print]

PMID:
29438490
19.

Impact of the Oral Adsorbent AST-120 on Organ-Specific Accumulation of Uremic Toxins: LC-MS/MS and MS Imaging Techniques.

Sato E, Saigusa D, Mishima E, Uchida T, Miura D, Morikawa-Ichinose T, Kisu K, Sekimoto A, Saito R, Oe Y, Matsumoto Y, Tomioka Y, Mori T, Takahashi N, Sato H, Abe T, Niwa T, Ito S.

Toxins (Basel). 2017 Dec 28;10(1). pii: E19. doi: 10.3390/toxins10010019.

20.

Evidence Suggests Sphingosine 1-Phosphate Might Be Actively Generated, Degraded, and Transported to Extracellular Spaces With Increased S1P2 and S1P3 Expression in Colon Cancer.

Uranbileg B, Nishikawa T, Ikeda H, Kurano M, Sato M, Saigusa D, Aoki J, Watanabe T, Yatomi Y.

Clin Colorectal Cancer. 2018 Jun;17(2):e171-e182. doi: 10.1016/j.clcc.2017.11.004. Epub 2017 Nov 21.

PMID:
29223361

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