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Items: 18

1.

Discovery of 2-(1-(3-(4-Chloroxyphenyl)-3-oxo- propyl)pyrrolidine-3-yl)-1H-benzo[d]imidazole-4-carboxamide: A Potent Poly(ADP-ribose) Polymerase (PARP) Inhibitor for Treatment of Cancer.

Min R, Wu W, Wang M, Tang L, Chen D, Zhao H, Zhang C, Jiang Y.

Molecules. 2019 May 17;24(10). pii: E1901. doi: 10.3390/molecules24101901.

2.

Development of a versatile DNMT and HDAC inhibitor C02S modulating multiple cancer hallmarks for breast cancer therapy.

Yuan Z, Chen S, Gao C, Dai Q, Zhang C, Sun Q, Lin JS, Guo C, Chen Y, Jiang Y.

Bioorg Chem. 2019 Jun;87:200-208. doi: 10.1016/j.bioorg.2019.03.027. Epub 2019 Mar 19.

PMID:
30901675
3.

Antiproliferative activities of the second-generation antipsychotic drug sertindole against breast cancers with a potential application for treatment of breast-to-brain metastases.

Zhang W, Zhang C, Liu F, Mao Y, Xu W, Fan T, Sun Q, He S, Chen Y, Guo W, Tan Y, Jiang Y.

Sci Rep. 2018 Oct 25;8(1):15753. doi: 10.1038/s41598-018-33740-0.

4.

Synthesis and biological research of novel azaacridine derivatives as potent DNA-binding ligands and topoisomerase II inhibitors.

Li D, Yuan Z, Chen S, Zhang C, Song L, Gao C, Chen Y, Tan C, Jiang Y.

Bioorg Med Chem. 2017 Jul 1;25(13):3437-3446. doi: 10.1016/j.bmc.2017.04.030. Epub 2017 May 4.

PMID:
28511910
5.

Novel multi-substituted benzyl acridone derivatives as survivin inhibitors for hepatocellular carcinoma treatment.

Zhang B, Wang N, Zhang C, Gao C, Zhang W, Chen K, Wu W, Chen Y, Tan C, Liu F, Jiang Y.

Eur J Med Chem. 2017 Mar 31;129:337-348. doi: 10.1016/j.ejmech.2017.02.027. Epub 2017 Feb 17.

PMID:
28237663
6.

Synthesis and investigation of novel 6-(1,2,3-triazol-4-yl)-4-aminoquinazolin derivatives possessing hydroxamic acid moiety for cancer therapy.

Ding C, Chen S, Zhang C, Hu G, Zhang W, Li L, Chen YZ, Tan C, Jiang Y.

Bioorg Med Chem. 2017 Jan 1;25(1):27-37. doi: 10.1016/j.bmc.2016.10.006. Epub 2016 Oct 10.

PMID:
27769671
7.

Clustered distribution of natural product leads of drugs in the chemical space as influenced by the privileged target-sites.

Tao L, Zhu F, Qin C, Zhang C, Chen S, Zhang P, Zhang C, Tan C, Gao C, Chen Z, Jiang Y, Chen YZ.

Sci Rep. 2015 Mar 20;5:9325. doi: 10.1038/srep09325.

8.

Multitarget inhibitors derived from crosstalk mechanism involving VEGFR2.

Ding C, Zhang C, Zhang M, Chen YZ, Tan C, Tan Y, Jiang Y.

Future Med Chem. 2014;6(16):1771-89. doi: 10.4155/fmc.14.112. Review.

PMID:
25407368
9.

Exploration of 1-(3-chloro-4-(4-oxo-4H-chromen-2-yl)phenyl)-3-phenylurea derivatives as selective dual inhibitors of Raf1 and JNK1 kinases for anti-tumor treatment.

Jin F, Gao D, Zhang C, Liu F, Chu B, Chen Y, Chen YZ, Tan C, Jiang Y.

Bioorg Med Chem. 2013 Feb 1;21(3):824-31. doi: 10.1016/j.bmc.2012.04.006. Epub 2012 Apr 11.

PMID:
23260578
10.

Development and experimental test of support vector machines virtual screening method for searching Src inhibitors from large compound libraries.

Han B, Ma X, Zhao R, Zhang J, Wei X, Liu X, Liu X, Zhang C, Tan C, Jiang Y, Chen Y.

Chem Cent J. 2012 Nov 23;6(1):139. doi: 10.1186/1752-153X-6-139.

11.

Selective VEGFR inhibitors for anticancer therapeutics in clinical use and clinical trials.

Zhang C, Tan C, Ding H, Xin T, Jiang Y.

Curr Pharm Des. 2012;18(20):2921-35. Review.

PMID:
22571661
12.

Synthesis and cytotoxic activity of some novel N-pyridinyl-2-(6-phenylimidazo[2,1-b]thiazol-3-yl)acetamide derivatives.

Ding H, Chen Z, Zhang C, Xin T, Wang Y, Song H, Jiang Y, Chen Y, Xu Y, Tan C.

Molecules. 2012 Apr 23;17(4):4703-16. doi: 10.3390/molecules17044703.

13.

2'-chloro-4'-aminoflavone derivatives selectively targeting hepatocarcinoma cells: convenient synthetic process, G(2)/M cell cycle arrest and apoptosis triggers.

Jin F, Zhang N, Tan C, Gao D, Zhang C, Liu F, Chen Z, Gao C, Liu H, Li S, Jiang Y.

Arch Pharm (Weinheim). 2012 Jul;345(7):525-34. doi: 10.1002/ardp.201100383. Epub 2012 Mar 30.

PMID:
22467491
14.

Design and synthesis of N-phosphoryl peptide modified podophyllotoxin derivatives as potent anticancer agents.

Hu X, Gao C, Tan C, Zhang C, Zhang H, Li S, Liu H, Jiang Y.

Protein Pept Lett. 2011 Dec;18(12):1258-64.

PMID:
21787278
15.

Discovery of benzimidazole derivatives as novel multi-target EGFR, VEGFR-2 and PDGFR kinase inhibitors.

Li Y, Tan C, Gao C, Zhang C, Luan X, Chen X, Liu H, Chen Y, Jiang Y.

Bioorg Med Chem. 2011 Aug 1;19(15):4529-35. doi: 10.1016/j.bmc.2011.06.022. Epub 2011 Jun 16.

PMID:
21724404
16.

2-Chloro-1-[4-(2-fluoro-benz-yl)piperazin-1-yl]ethanone.

Zhang C, Zhai X, Wan F, Gong P, Jiang Y.

Acta Crystallogr Sect E Struct Rep Online. 2011 Feb 26;67(Pt 3):o708. doi: 10.1107/S1600536811006180.

17.

An effective method for de novo peptide sequencing based on phosphorylation strategy and mass spectrometry.

Zhang D, Liu H, Zhang S, Chen X, Li S, Zhang C, Hu X, Bi K, Chen X, Jiang Y.

Talanta. 2011 May 15;84(3):614-22. doi: 10.1016/j.talanta.2010.12.035. Epub 2011 Jan 8.

PMID:
21482258
18.

Exploration of (S)-3-aminopyrrolidine as a potentially interesting scaffold for discovery of novel Abl and PI3K dual inhibitors.

Zhang C, Tan C, Zu X, Zhai X, Liu F, Chu B, Ma X, Chen Y, Gong P, Jiang Y.

Eur J Med Chem. 2011 Apr;46(4):1404-14. doi: 10.1016/j.ejmech.2011.01.020. Epub 2011 Jan 21.

PMID:
21295380

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