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Items: 1 to 20 of 39

1.

Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold.

Rotondi G, Guglielmi P, Carradori S, Secci D, De Monte C, De Filippis B, Maccallini C, Amoroso R, Cirilli R, Akdemir A, Angeli A, Supuran CT.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):1400-1413. doi: 10.1080/14756366.2019.1651315.

2.

Synthesis of novel benzothiazole amides: Evaluation of PPAR activity and anti-proliferative effects in paraganglioma, pancreatic and colorectal cancer cell lines.

Ammazzalorso A, De Lellis L, Florio R, Laghezza A, De Filippis B, Fantacuzzi M, Giampietro L, Maccallini C, Tortorella P, Veschi S, Loiodice F, Cama A, Amoroso R.

Bioorg Med Chem Lett. 2019 Aug 15;29(16):2302-2306. doi: 10.1016/j.bmcl.2019.06.020. Epub 2019 Jun 18.

PMID:
31272790
3.

Fibrate-based N-acylsulphonamides targeting carbonic anhydrases: synthesis, biochemical evaluation, and docking studies.

Ammazzalorso A, Carradori S, Angeli A, Akdemir A, De Filippis B, Fantacuzzi M, Giampietro L, Maccallini C, Amoroso R, Supuran CT.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):1051-1061. doi: 10.1080/14756366.2019.1611801.

4.

Multitarget PPARγ agonists as innovative modulators of the metabolic syndrome.

Ammazzalorso A, Maccallini C, Amoia P, Amoroso R.

Eur J Med Chem. 2019 Jul 1;173:261-273. doi: 10.1016/j.ejmech.2019.04.030. Epub 2019 Apr 13. Review.

PMID:
31009912
5.

Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome.

Giampietro L, Laghezza A, Cerchia C, Florio R, Recinella L, Capone F, Ammazzalorso A, Bruno I, De Filippis B, Fantacuzzi M, Ferrante C, Maccallini C, Tortorella P, Verginelli F, Brunetti L, Cama A, Amoroso R, Loiodice F, Lavecchia A.

ACS Med Chem Lett. 2019 Feb 25;10(4):545-551. doi: 10.1021/acsmedchemlett.8b00574. eCollection 2019 Apr 11.

PMID:
30996794
6.

The Selective Acetamidine-Based iNOS Inhibitor CM544 Reduces Glioma Cell Proliferation by Enhancing PARP-1 Cleavage In Vitro.

Gallorini M, Maccallini C, Ammazzalorso A, Amoia P, De Filippis B, Fantacuzzi M, Giampietro L, Cataldi A, Amoroso R.

Int J Mol Sci. 2019 Jan 24;20(3). pii: E495. doi: 10.3390/ijms20030495.

7.

Discovery of new FXR agonists based on 6-ECDCA binding properties by virtual screening and molecular docking.

Giancristofaro A, Barbosa AJM, Ammazzalorso A, Amoia P, De Filippis B, Fantacuzzi M, Giampietro L, Maccallini C, Amoroso R.

Medchemcomm. 2018 Jul 4;9(10):1630-1638. doi: 10.1039/c8md00272j. eCollection 2018 Oct 1.

8.

Discovery of N-{3-[(ethanimidoylamino)methyl]benzyl}-l-prolinamide dihydrochloride: A new potent and selective inhibitor of the inducible nitric oxide synthase as a promising agent for the therapy of malignant glioma.

Maccallini C, Di Matteo M, Gallorini M, Montagnani M, Graziani V, Ammazzalorso A, Amoia P, De Filippis B, Di Silvestre S, Fantacuzzi M, Giampietro L, Potenza MA, Re N, Pandolfi A, Cataldi A, Amoroso R.

Eur J Med Chem. 2018 May 25;152:53-64. doi: 10.1016/j.ejmech.2018.04.027. Epub 2018 Apr 13.

PMID:
29689474
9.

Cytotoxic effect of a family of peroxisome proliferator-activated receptor antagonists in colorectal and pancreatic cancer cell lines.

Ammazzalorso A, De Lellis L, Florio R, Bruno I, De Filippis B, Fantacuzzi M, Giampietro L, Maccallini C, Perconti S, Verginelli F, Cama A, Amoroso R.

Chem Biol Drug Des. 2017 Nov;90(5):1029-1035. doi: 10.1111/cbdd.13026. Epub 2017 Jul 19.

PMID:
28544586
10.

Targeting Malassezia species for Novel Synthetic and Natural Antidandruff Agents.

Angiolella L, Carradori S, Maccallini C, Giusiano G, Supuran CT.

Curr Med Chem. 2017;24(22):2392-2412. doi: 10.2174/0929867324666170404110631. Review.

PMID:
28393697
11.

The Positive Regulation of eNOS Signaling by PPAR Agonists in Cardiovascular Diseases.

Maccallini C, Mollica A, Amoroso R.

Am J Cardiovasc Drugs. 2017 Aug;17(4):273-281. doi: 10.1007/s40256-017-0220-9. Review.

PMID:
28315197
12.

Anticancer Activity of Stilbene-Based Derivatives.

De Filippis B, Ammazzalorso A, Fantacuzzi M, Giampietro L, Maccallini C, Amoroso R.

ChemMedChem. 2017 Apr 20;12(8):558-570. doi: 10.1002/cmdc.201700045. Epub 2017 Mar 28. Review.

PMID:
28266812
13.

Targeting neuronal nitric oxide synthase as a valuable strategy for the therapy of neurological disorders.

Maccallini C, Amoroso R.

Neural Regen Res. 2016 Nov;11(11):1731-1734. doi: 10.4103/1673-5374.194707. Review.

14.

Hemopressin Peptides as Modulators of the Endocannabinoid System and their Potential Applications as Therapeutic Tools.

Macedonio G, Stefanucci A, Maccallini C, Mirzaie S, Novellino E, Mollica A.

Protein Pept Lett. 2016;23(12):1045-1051. Review.

PMID:
27748182
15.

Indazole, Pyrazole, and Oxazole Derivatives Targeting Nitric Oxide Synthases and Carbonic Anhydrases.

Maccallini C, Di Matteo M, Vullo D, Ammazzalorso A, Carradori S, De Filippis B, Fantacuzzi M, Giampietro L, Pandolfi A, Supuran CT, Amoroso R.

ChemMedChem. 2016 Aug 19;11(16):1695-9. doi: 10.1002/cmdc.201600204. Epub 2016 Jul 5.

PMID:
27377568
16.

Synthesis and biological characterization of 3-(imidazol-1-ylmethyl)piperidine sulfonamides as aromatase inhibitors.

Di Matteo M, Ammazzalorso A, Andreoli F, Caffa I, De Filippis B, Fantacuzzi M, Giampietro L, Maccallini C, Nencioni A, Parenti MD, Soncini D, Del Rio A, Amoroso R.

Bioorg Med Chem Lett. 2016 Jul 1;26(13):3192-3194. doi: 10.1016/j.bmcl.2016.04.078. Epub 2016 Apr 28.

PMID:
27161804
17.

Synthesis, in vitro evaluation, and molecular modeling investigation of benzenesulfonimide peroxisome proliferator-activated receptors α antagonists.

Ammazzalorso A, Carrieri A, Verginelli F, Bruno I, Carbonara G, D'Angelo A, De Filippis B, Fantacuzzi M, Florio R, Fracchiolla G, Giampietro L, Giancristofaro A, Maccallini C, Cama A, Amoroso R.

Eur J Med Chem. 2016 May 23;114:191-200. doi: 10.1016/j.ejmech.2016.02.064. Epub 2016 Feb 27.

PMID:
26974385
18.

Screening of NOS activity and selectivity of newly synthesized acetamidines using RP-HPLC.

Fantacuzzi M, Maccallini C, Di Matteo M, Ammazzalorso A, Bruno I, De Filippis B, Giampietro L, Mollica A, Amoroso R.

J Pharm Biomed Anal. 2016 Feb 20;120:419-24. doi: 10.1016/j.jpba.2015.11.045. Epub 2015 Dec 2.

PMID:
26689740
19.

Synthesis of Naphthyl-, Quinolin- and Anthracenyl Analogues of Clofibric Acid as PPARα Agonists.

Giampietro L, Ammazzalorso A, Bruno I, Carradori S, De Filippis B, Fantacuzzi M, Giancristofaro A, Maccallini C, Amoroso R.

Chem Biol Drug Des. 2016 Mar;87(3):467-71. doi: 10.1111/cbdd.12677. Epub 2015 Nov 20.

PMID:
26502898
20.

Selective Acetamidine-Based Nitric Oxide Synthase Inhibitors: Synthesis, Docking, and Biological Studies.

Maccallini C, Montagnani M, Paciotti R, Ammazzalorso A, De Filippis B, Di Matteo M, Di Silvestre S, Fantacuzzi M, Giampietro L, Potenza MA, Re N, Pandolfi A, Amoroso R.

ACS Med Chem Lett. 2015 Apr 28;6(6):635-40. doi: 10.1021/acsmedchemlett.5b00149. eCollection 2015 Jun 11.

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