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Breakthrough Bloodstream Infections Caused by Echinocandin-Resistant Candida tropicalis: An Emerging Threat to Immunocompromised Patients with Hematological Malignancies.

Sfeir MM, Jiménez-Ortigosa C, Gamaletsou MN, Schuetz AN, Soave R, Besien KV, Small CB, Perlin DS, Walsh TJ.

J Fungi (Basel). 2020 Jan 31;6(1). pii: E20. doi: 10.3390/jof6010020.


Novel FKS1 and FKS2 modifications in a high-level echinocandin resistant clinical isolate of Candida glabrata.

Hou X, Healey KR, Shor E, Kordalewska M, Ortigosa CJ, Paderu P, Xiao M, Wang H, Zhao Y, Lin LY, Zhang YH, Li YZ, Xu YC, Perlin DS, Zhao Y.

Emerg Microbes Infect. 2019;8(1):1619-1625. doi: 10.1080/22221751.2019.1684209.


Stress-Induced Changes in the Lipid Microenvironment of β-(1,3)-d-Glucan Synthase Cause Clinically Important Echinocandin Resistance in Aspergillus fumigatus.

Satish S, Jiménez-Ortigosa C, Zhao Y, Lee MH, Dolgov E, Krüger T, Park S, Denning DW, Kniemeyer O, Brakhage AA, Perlin DS.

mBio. 2019 Jun 4;10(3). pii: e00779-19. doi: 10.1128/mBio.00779-19.


Rapid Detection of ERG11-Associated Azole Resistance and FKS-Associated Echinocandin Resistance in Candida auris.

Hou X, Lee A, Jiménez-Ortigosa C, Kordalewska M, Perlin DS, Zhao Y.

Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01811-18. doi: 10.1128/AAC.01811-18. Print 2019 Jan.


Limited ERG11 Mutations Identified in Isolates of Candida auris Directly Contribute to Reduced Azole Susceptibility.

Healey KR, Kordalewska M, Jiménez Ortigosa C, Singh A, Berrío I, Chowdhary A, Perlin DS.

Antimicrob Agents Chemother. 2018 Sep 24;62(10). pii: e01427-18. doi: 10.1128/AAC.01427-18. Print 2018 Oct.


Significantly Improved Pharmacokinetics Enhances In Vivo Efficacy of APX001 against Echinocandin- and Multidrug-Resistant Candida Isolates in a Mouse Model of Invasive Candidiasis.

Zhao Y, Lee MH, Paderu P, Lee A, Jimenez-Ortigosa C, Park S, Mansbach RS, Shaw KJ, Perlin DS.

Antimicrob Agents Chemother. 2018 Sep 24;62(10). pii: e00425-18. doi: 10.1128/AAC.00425-18. Print 2018 Oct.


Correction for Yang et al., "Tolerance to Caspofungin in Candida albicans Is Associated with at Least Three Distinctive Mechanisms That Govern Expression of FKS Genes and Cell Wall Remodeling".

Yang F, Zhang L, Wakabayashi H, Myers J, Jiang Y, Cao Y, Jimenez-Ortigosa C, Perlin DS, Rustchenko E.

Antimicrob Agents Chemother. 2018 Mar 27;62(4). pii: e00386-18. doi: 10.1128/AAC.00386-18. Print 2018 Apr. No abstract available.


Comparative study of Candida spp. isolates: Identification and echinocandin susceptibility in isolates obtained from blood cultures in 15 hospitals in Medellín, Colombia.

Berrio I, Maldonado N, De Bedout C, Arango K, Cano LE, Valencia Y, Jiménez-Ortigosa C, Perlin DS, Gómez BL, Robledo C, Robledo J; Grupo GERMEN.

J Glob Antimicrob Resist. 2018 Jun;13:254-260. doi: 10.1016/j.jgar.2017.11.010. Epub 2017 Nov 26.


Emergence of Echinocandin Resistance Due to a Point Mutation in the fks1 Gene of Aspergillus fumigatus in a Patient with Chronic Pulmonary Aspergillosis.

Jiménez-Ortigosa C, Moore C, Denning DW, Perlin DS.

Antimicrob Agents Chemother. 2017 Nov 22;61(12). pii: e01277-17. doi: 10.1128/AAC.01277-17. Print 2017 Dec.


De Novo Acquisition of Resistance to SCY-078 in Candida glabrata Involves FKS Mutations That both Overlap and Are Distinct from Those Conferring Echinocandin Resistance.

Jiménez-Ortigosa C, Perez WB, Angulo D, Borroto-Esoda K, Perlin DS.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00833-17. doi: 10.1128/AAC.00833-17. Print 2017 Sep.


Changes in In Vitro Susceptibility Patterns of Aspergillus to Triazoles and Correlation With Aspergillosis Outcome in a Tertiary Care Cancer Center, 1999-2015.

Heo ST, Tatara AM, Jiménez-Ortigosa C, Jiang Y, Lewis RE, Tarrand J, Tverdek F, Albert ND, Verweij PE, Meis JF, Mikos AG, Perlin DS, Kontoyiannis DP.

Clin Infect Dis. 2017 Jul 15;65(2):216-225. doi: 10.1093/cid/cix297.


Tolerance to Caspofungin in Candida albicans Is Associated with at Least Three Distinctive Mechanisms That Govern Expression of FKS Genes and Cell Wall Remodeling.

Yang F, Zhang L, Wakabayashi H, Myers J, Jiang Y, Cao Y, Jimenez-Ortigosa C, Perlin DS, Rustchenko E.

Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e00071-17. doi: 10.1128/AAC.00071-17. Print 2017 May. Erratum in: Antimicrob Agents Chemother. 2018 Mar 27;62(4):.


Genetic Drivers of Multidrug Resistance in Candida glabrata.

Healey KR, Jimenez Ortigosa C, Shor E, Perlin DS.

Front Microbiol. 2016 Dec 15;7:1995. doi: 10.3389/fmicb.2016.01995. eCollection 2016.


CD101: a novel long-acting echinocandin.

Zhao Y, Perez WB, Jiménez-Ortigosa C, Hough G, Locke JB, Ong V, Bartizal K, Perlin DS.

Cell Microbiol. 2016 Sep;18(9):1308-16. doi: 10.1111/cmi.12640. Epub 2016 Jul 22.


Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance.

Healey KR, Zhao Y, Perez WB, Lockhart SR, Sobel JD, Farmakiotis D, Kontoyiannis DP, Sanglard D, Taj-Aldeen SJ, Alexander BD, Jimenez-Ortigosa C, Shor E, Perlin DS.

Nat Commun. 2016 Mar 29;7:11128. doi: 10.1038/ncomms11128.


Quick Detection of FKS1 Mutations Responsible for Clinical Echinocandin Resistance in Candida albicans.

Dudiuk C, Gamarra S, Jimenez-Ortigosa C, Leonardelli F, Macedo D, Perlin DS, Garcia-Effron G.

J Clin Microbiol. 2015 Jul;53(7):2037-41. doi: 10.1128/JCM.00398-15. Epub 2015 Apr 15.


Breakthrough candidaemia caused by phenotypically susceptible Candida spp. in patients with haematological malignancies does not correlate with established interpretive breakpoints.

Gamaletsou MN, Daikos GL, Walsh TJ, Perlin DS, Ortigosa CJ, Psaroulaki A, Pagoni M, Argyropoulou A, Nepka M, Perivolioti E, Kotsopoulou M, Perloretzou S, Marangos M, Kofteridis D, Grammatikou M, Goukos D, Petrikkos G, Sipsas NV.

Int J Antimicrob Agents. 2014 Sep;44(3):248-55. doi: 10.1016/j.ijantimicag.2014.05.015. Epub 2014 Jun 30.


Target enzyme mutations confer differential echinocandin susceptibilities in Candida kefyr.

Staab JF, Neofytos D, Rhee P, Jiménez-Ortigosa C, Zhang SX, Perlin DS, Marr KA.

Antimicrob Agents Chemother. 2014 Sep;58(9):5421-7. doi: 10.1128/AAC.00096-14. Epub 2014 Jun 30.


Set of classical PCRs for detection of mutations in Candida glabrata FKS genes linked with echinocandin resistance.

Dudiuk C, Gamarra S, Leonardeli F, Jimenez-Ortigosa C, Vitale RG, Afeltra J, Perlin DS, Garcia-Effron G.

J Clin Microbiol. 2014 Jul;52(7):2609-14. doi: 10.1128/JCM.01038-14. Epub 2014 May 14.


Breakthrough candidemia due to multidrug-resistant Candida glabrata during prophylaxis with a low dose of micafungin.

Bizerra FC, Jimenez-Ortigosa C, Souza AC, Breda GL, Queiroz-Telles F, Perlin DS, Colombo AL.

Antimicrob Agents Chemother. 2014;58(4):2438-40. doi: 10.1128/AAC.02189-13. Epub 2014 Jan 27.

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