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Items: 1 to 20 of 32


Topical delivery of mTOR inhibitor halts scarring.

Webber LP, Yip B, Nascimento Filho CHVD, Park HB, Castilho RM, Squarize CH.

J Dermatol Sci. 2019 Jul 4. pii: S0923-1811(19)30175-6. doi: 10.1016/j.jdermsci.2019.06.008. [Epub ahead of print] No abstract available.


Interference with the bromodomain epigenome readers drives p21 expression and tumor senescence.

Webber LP, Yujra VQ, Vargas PA, Martins MD, Squarize CH, Castilho RM.

Cancer Lett. 2019 Oct 1;461:10-20. doi: 10.1016/j.canlet.2019.06.019. Epub 2019 Jun 29.


Characterization of macrophage polarization in periodontal disease.

Garaicoa-Pazmino C, Fretwurst T, Squarize CH, Berglundh T, Giannobile WV, Larsson L, Castilho RM.

J Clin Periodontol. 2019 Aug;46(8):830-839. doi: 10.1111/jcpe.13156. Epub 2019 Jun 25.


Interfering with bromodomain epigenome readers as therapeutic option in mucoepidermoid carcinoma.

Markman RL, Webber LP, Nascimento Filho CHV, Reis LA, Vargas PA, Lopes MA, Zanella V, Martins MD, Squarize CH, Castilho RM.

Cell Oncol (Dordr). 2019 Apr;42(2):143-155. doi: 10.1007/s13402-018-0416-2. Epub 2018 Dec 11.


Dental implants-associated release of titanium particles: A systematic review.

Suárez-López Del Amo F, Garaicoa-Pazmiño C, Fretwurst T, Castilho RM, Squarize CH.

Clin Oral Implants Res. 2018 Oct 2. doi: 10.1111/clr.13372. [Epub ahead of print] Review.


Targeting histone deacetylase and NFκB signaling as a novel therapy for Mucoepidermoid Carcinomas.

Wagner VP, Martins MD, Martins MAT, Almeida LO, Warner KA, Nör JE, Squarize CH, Castilho RM.

Sci Rep. 2018 Feb 1;8(1):2065. doi: 10.1038/s41598-018-20345-w.


Epigenetic Modifications and Head and Neck Cancer: Implications for Tumor Progression and Resistance to Therapy.

Castilho RM, Squarize CH, Almeida LO.

Int J Mol Sci. 2017 Jul 12;18(7). pii: E1506. doi: 10.3390/ijms18071506. Review.


PTEN Mediates Activation of Core Clock Protein BMAL1 and Accumulation of Epidermal Stem Cells.

Zagni C, Almeida LO, Balan T, Martins MT, Rosselli-Murai LK, Papagerakis P, Castilho RM, Squarize CH.

Stem Cell Reports. 2017 Jul 11;9(1):304-314. doi: 10.1016/j.stemcr.2017.05.006. Epub 2017 Jun 8.


Unlocking the chromatin of adenoid cystic carcinomas using HDAC inhibitors sensitize cancer stem cells to cisplatin and induces tumor senescence.

Almeida LO, Guimarães DM, Martins MD, Martins MAT, Warner KA, Nör JE, Castilho RM, Squarize CH.

Stem Cell Res. 2017 May;21:94-105. doi: 10.1016/j.scr.2017.04.003. Epub 2017 Apr 8. No abstract available.


Hypoacetylation of acetyl-histone H3 (H3K9ac) as marker of poor prognosis in oral cancer.

Webber LP, Wagner VP, Curra M, Vargas PA, Meurer L, Carrard VC, Squarize CH, Castilho RM, Martins MD.

Histopathology. 2017 Aug;71(2):278-286. doi: 10.1111/his.13218. Epub 2017 May 23.


Overcoming adaptive resistance in mucoepidermoid carcinoma through inhibition of the IKK-β/IκBα/NFκB axis.

Wagner VP, Martins MA, Martins MD, Warner KA, Webber LP, Squarize CH, Nör JE, Castilho RM.

Oncotarget. 2016 Nov 8;7(45):73032-73044. doi: 10.18632/oncotarget.12195.


Sensitizing mucoepidermoid carcinomas to chemotherapy by targeted disruption of cancer stem cells.

Guimarães DM, Almeida LO, Martins MD, Warner KA, Silva AR, Vargas PA, Nunes FD, Squarize CH, Nör JE, Castilho RM.

Oncotarget. 2016 Jul 5;7(27):42447-42460. doi: 10.18632/oncotarget.9884.


PI3K-PTEN dysregulation leads to mTOR-driven upregulation of the core clock gene BMAL1 in normal and malignant epithelial cells.

Matsumoto CS, Almeida LO, Guimarães DM, Martins MD, Papagerakis P, Papagerakis S, Leopoldino AM, Castilho RM, Squarize CH.

Oncotarget. 2016 Jul 5;7(27):42393-42407. doi: 10.18632/oncotarget.9877.


Profiling the Behavior of Distinct Populations of Head and Neck Cancer Stem Cells.

Almeida LO, Guimarães DM, Squarize CH, Castilho RM.

Cancers (Basel). 2016 Jan 4;8(1). pii: E7. doi: 10.3390/cancers8010007.


Epigenetic Modifications and Accumulation of DNA Double-Strand Breaks in Oral Lichen Planus Lesions Presenting Poor Response to Therapy.

Dillenburg CS, Martins MA, Almeida LO, Meurer L, Squarize CH, Martins MD, Castilho RM.

Medicine (Baltimore). 2015 Jul;94(30):e997. doi: 10.1097/MD.0000000000000997.


Oral Rehabilitation of Adult Edentulous Siblings Severely Lacking Alveolar Bone Due to Ectodermal Dysplasia: A Report of 2 Clinical Cases and a Literature Review.

Wu Y, Zhang C, Squarize CH, Zou D.

J Oral Maxillofac Surg. 2015 Sep;73(9):1733.e1-12. doi: 10.1016/j.joms.2015.03.065. Epub 2015 Apr 18. Review.


Histone modifications: Targeting head and neck cancer stem cells.

Le JM, Squarize CH, Castilho RM.

World J Stem Cells. 2014 Nov 26;6(5):511-25. doi: 10.4252/wjsc.v6.i5.511. Review.


The determinants of head and neck cancer: Unmasking the PI3K pathway mutations.

Giudice FS, Squarize CH.

J Carcinog Mutagen. 2013 Aug 2;Suppl 5. pii: 003.


Laser phototherapy accelerates oral keratinocyte migration through the modulation of the mammalian target of rapamycin signaling pathway.

Pellicioli AC, Martins MD, Dillenburg CS, Marques MM, Squarize CH, Castilho RM.

J Biomed Opt. 2014 Feb;19(2):028002. doi: 10.1117/1.JBO.19.2.028002.


NFκB mediates cisplatin resistance through histone modifications in head and neck squamous cell carcinoma (HNSCC).

Almeida LO, Abrahao AC, Rosselli-Murai LK, Giudice FS, Zagni C, Leopoldino AM, Squarize CH, Castilho RM.

FEBS Open Bio. 2013 Dec 30;4:96-104. doi: 10.1016/j.fob.2013.12.003. eCollection 2014.

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