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Items: 15

1.

3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance.

Titov AA, Niso M, Candia M, Kobzev MS, Varlamov AV, Borisova TN, Voskressensky LG, Colabufo NA, Cellamare S, Pisani L, Altomare CD.

Future Med Chem. 2019 Aug;11(16):2095-2106. doi: 10.4155/fmc-2019-0037.

PMID:
31538529
2.

Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease.

Purgatorio R, de Candia M, Catto M, Carrieri A, Pisani L, De Palma A, Toma M, Ivanova OA, Voskressensky LG, Altomare CD.

Eur J Med Chem. 2019 Sep 1;177:414-424. doi: 10.1016/j.ejmech.2019.05.062. Epub 2019 May 28.

PMID:
31158754
3.

A New Class of 1-Aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline Derivatives as Reversers of P-Glycoprotein-Mediated Multidrug Resistance in Tumor Cells.

Nevskaya AA, Matveeva MD, Borisova TN, Niso M, Colabufo NA, Boccarelli A, Purgatorio R, de Candia M, Cellamare S, Voskressensky LG, Altomare CD.

ChemMedChem. 2018 Aug 10;13(15):1588-1596. doi: 10.1002/cmdc.201800177. Epub 2018 Jul 4.

PMID:
29802687
4.

The position of fluorine in CP-118,954 affects AChE inhibition potency and PET imaging quantification for AChE expression in the rat brain.

Lee BC, Moon BS, Park HS, Jung JH, Park HS, Park DD, de Candia M, Denora N, Altomare CD, Kim SE.

Eur J Pharm Sci. 2017 Nov 15;109:209-216. doi: 10.1016/j.ejps.2017.08.008. Epub 2017 Aug 15.

PMID:
28818531
5.

Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl)hydrazone: A water-soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid fibrillization and oligomer-induced cytotoxicity.

Pisani L, De Palma A, Giangregorio N, Miniero DV, Pesce P, Nicolotti O, Campagna F, Altomare CD, Catto M.

Eur J Pharm Sci. 2017 Nov 15;109:381-388. doi: 10.1016/j.ejps.2017.08.004. Epub 2017 Aug 9.

PMID:
28801274
6.

Oxazepam-Dopamine Conjugates Increase Dopamine Delivery into Striatum of Intact Rats.

Cassano T, Lopalco A, de Candia M, Laquintana V, Lopedota A, Cutrignelli A, Perrone M, Iacobazzi RM, Bedse G, Franco M, Denora N, Altomare CD.

Mol Pharm. 2017 Sep 5;14(9):3178-3187. doi: 10.1021/acs.molpharmaceut.7b00405. Epub 2017 Aug 22.

PMID:
28780872
7.

Discovery of Potent Dual Binding Site Acetylcholinesterase Inhibitors via Homo- and Heterodimerization of Coumarin-Based Moieties.

Pisani L, Catto M, De Palma A, Farina R, Cellamare S, Altomare CD.

ChemMedChem. 2017 Aug 22;12(16):1349-1358. doi: 10.1002/cmdc.201700282. Epub 2017 Jun 29.

PMID:
28570763
8.

Pharmaceutical development of novel lactate-based 6-fluoro-l-DOPA formulations.

Denora N, Lopedota A, de Candia M, Cellamare S, Degennaro L, Luisi R, Mele A, Tricarico D, Cutrignelli A, Laquintana V, Altomare CD, Franco M, Dimiccoli V, Tolomeo A, Scilimati A.

Eur J Pharm Sci. 2017 Mar 1;99:361-368. doi: 10.1016/j.ejps.2016.10.001. Epub 2016 Oct 4.

PMID:
27717874
9.

New azepino[4,3-b]indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effects against NMDA-induced neurotoxicity.

de Candia M, Zaetta G, Denora N, Tricarico D, Majellaro M, Cellamare S, Altomare CD.

Eur J Med Chem. 2017 Jan 5;125:288-298. doi: 10.1016/j.ejmech.2016.09.037. Epub 2016 Sep 13.

PMID:
27688184
10.

Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases.

Farina R, Pisani L, Catto M, Nicolotti O, Gadaleta D, Denora N, Soto-Otero R, Mendez-Alvarez E, Passos CS, Muncipinto G, Altomare CD, Nurisso A, Carrupt PA, Carotti A.

J Med Chem. 2015 Jul 23;58(14):5561-78. doi: 10.1021/acs.jmedchem.5b00599. Epub 2015 Jul 9.

PMID:
26107513
11.

Galloyl benzamide-based compounds modulating tumour necrosis factor α-stimulated c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signalling pathways.

Leo V, Stefanachi A, Nacci C, Leonetti F, de Candia M, Carotti A, Altomare CD, Montagnani M, Cellamare S.

J Pharm Pharmacol. 2015 Oct;67(10):1380-92. doi: 10.1111/jphp.12438. Epub 2015 Jun 16.

PMID:
26078032
12.

2-Phenylimidazo[1,2-a]pyridine-containing ligands of the 18-kDa translocator protein (TSPO) behave as agonists and antagonists of steroidogenesis in a mouse leydig tumor cell line.

Midzak A, Denora N, Laquintana V, Cutrignelli A, Lopedota A, Franco M, Altomare CD, Papadopoulos V.

Eur J Pharm Sci. 2015 Aug 30;76:231-7. doi: 10.1016/j.ejps.2015.05.021. Epub 2015 May 19.

PMID:
26002041
13.

New organic nitrate-containing benzyloxy isonipecotanilide derivatives with vasodilatory and anti-platelet activity.

de Candia M, Marini E, Zaetta G, Cellamare S, Di Stilo A, Altomare CD.

Eur J Pharm Sci. 2015 May 25;72:69-80. doi: 10.1016/j.ejps.2015.03.004. Epub 2015 Mar 10.

14.

How a β-D-glucoside side chain enhances binding affinity to thrombin of inhibitors bearing 2-chlorothiophene as P1 moiety: crystallography, fragment deconstruction study, and evaluation of antithrombotic properties.

Belviso BD, Caliandro R, de Candia M, Zaetta G, Lopopolo G, Incampo F, Colucci M, Altomare CD.

J Med Chem. 2014 Oct 23;57(20):8563-75. doi: 10.1021/jm5010754. Epub 2014 Oct 14.

PMID:
25268757
15.

Synthesis and biophysical evaluation of arylhydrazono-1H-2-indolinones as β-amyloid aggregation inhibitors.

Campagna F, Catto M, Purgatorio R, Altomare CD, Carotti A, De Stradis A, Palazzo G.

Eur J Med Chem. 2011 Jan;46(1):275-84. doi: 10.1016/j.ejmech.2010.11.015. Epub 2010 Nov 18.

PMID:
21144622

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