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Items: 1 to 20 of 49

1.

Structure-activity relationships in a series of antiplasmodial thieno[2,3-b]pyridines.

Masch A, Nasereddin A, Alder A, Bird MJ, Schweda SI, Preu L, Doerig C, Dzikowski R, Gilberger TW, Kunick C.

Malar J. 2019 Mar 21;18(1):89. doi: 10.1186/s12936-019-2725-y.

2.

Trypanothione synthetase confers growth, survival advantage and resistance to anti-protozoal drugs in Trypanosoma cruzi.

Mesías AC, Sasoni N, Arias DG, Pérez Brandán C, Orban OCF, Kunick C, Robello C, Comini MA, Garg NJ, Zago MP.

Free Radic Biol Med. 2019 Jan;130:23-34. doi: 10.1016/j.freeradbiomed.2018.10.436. Epub 2018 Oct 23.

PMID:
30359758
3.

Biochemical and Epigenetic Insights into L-2-Hydroxyglutarate, a Potential Therapeutic Target in Renal Cancer.

Shelar S, Shim EH, Brinkley GJ, Kundu A, Carobbio F, Poston T, Tan J, Parekh V, Benson D, Crossman DK, Buckhaults PJ, Rakheja D, Kirkman R, Sato Y, Ogawa S, Dutta S, Velu SE, Emberley E, Pan A, Chen J, Huang T, Absher D, Becker A, Kunick C, Sudarshan S.

Clin Cancer Res. 2018 Dec 15;24(24):6433-6446. doi: 10.1158/1078-0432.CCR-18-1727. Epub 2018 Aug 14.

PMID:
30108105
4.

Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype.

Walter A, Chaikuad A, Helmer R, Loaëc N, Preu L, Ott I, Knapp S, Meijer L, Kunick C.

PLoS One. 2018 May 3;13(5):e0196761. doi: 10.1371/journal.pone.0196761. eCollection 2018.

5.

Indole-3-Carbonitriles as DYRK1A Inhibitors by Fragment-Based Drug Design.

Meine R, Becker W, Falke H, Preu L, Loaëc N, Meijer L, Kunick C.

Molecules. 2018 Jan 24;23(2). pii: E64. doi: 10.3390/molecules23020064.

6.

Early process development of API applied to poorly water-soluble TBID.

Meise M, Niggemann M, Dunens A, Schoenitz M, Kuschnerow JC, Kunick C, Scholl S.

Eur J Pharm Biopharm. 2018 May;126:2-9. doi: 10.1016/j.ejpb.2018.01.008. Epub 2018 Jan 12. Review.

PMID:
29339163
7.

Fast and calibration free determination of first order reaction kinetics in API synthesis using in-situ ATR-FTIR.

Rehbein MC, Husmann S, Lechner C, Kunick C, Scholl S.

Eur J Pharm Biopharm. 2018 May;126:95-100. doi: 10.1016/j.ejpb.2017.09.013. Epub 2017 Sep 28.

PMID:
28963069
8.

Antiplasmodial dihetarylthioethers target the coenzyme A synthesis pathway in Plasmodium falciparum erythrocytic stages.

Weidner T, Lucantoni L, Nasereddin A, Preu L, Jones PG, Dzikowski R, Avery VM, Kunick C.

Malar J. 2017 May 15;16(1):192. doi: 10.1186/s12936-017-1839-3.

9.

Scaffold hopping identifies 6,8-disubstituted purines as novel anaplastic lymphoma kinase inhibitors.

Schlütke L, Immer M, Preu L, Totzke F, Schächtele C, Kubbutat MHG, Kunick C.

Eur J Pharm Biopharm. 2018 May;126:89-94. doi: 10.1016/j.ejpb.2017.03.011. Epub 2017 Mar 15.

PMID:
28315448
10.

Identification of CLK1 Inhibitors by a Fragment-linking Based Virtual Screening.

Walter A, Chaikuad A, Loaëc N, Preu L, Knapp S, Meijer L, Kunick C, Koch O.

Mol Inform. 2017 Apr;36(4). doi: 10.1002/minf.201600123. Epub 2016 Dec 21.

PMID:
28000414
11.

Hierarchical phosphorylation of apical membrane antigen 1 is required for efficient red blood cell invasion by malaria parasites.

Prinz B, Harvey KL, Wilcke L, Ruch U, Engelberg K, Biller L, Lucet I, Erkelenz S, Heincke D, Spielmann T, Doerig C, Kunick C, Crabb BS, Gilson PR, Gilberger TW.

Sci Rep. 2016 Oct 4;6:34479. doi: 10.1038/srep34479.

12.

5-Substituted 3-chlorokenpaullone derivatives are potent inhibitors of Trypanosoma brucei bloodstream forms.

Orban OC, Korn RS, Benítez D, Medeiros A, Preu L, Loaëc N, Meijer L, Koch O, Comini MA, Kunick C.

Bioorg Med Chem. 2016 Aug 15;24(16):3790-800. doi: 10.1016/j.bmc.2016.06.023. Epub 2016 Jun 13.

PMID:
27349574
13.

Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids.

Benítez D, Medeiros A, Fiestas L, Panozzo-Zenere EA, Maiwald F, Prousis KC, Roussaki M, Calogeropoulou T, Detsi A, Jaeger T, Šarlauskas J, Peterlin Mašič L, Kunick C, Labadie GR, Flohé L, Comini MA.

PLoS Negl Trop Dis. 2016 Apr 12;10(4):e0004617. doi: 10.1371/journal.pntd.0004617. eCollection 2016 Apr.

14.

Novel 2-Phenoxyanilide Congeners Derived from a Hit Structure of the TCAMS: Synthesis and Evaluation of Their in Vitro Activity against Plasmodium falciparum.

Weidner T, Nasereddin A, Preu L, Grünefeld J, Dzikowski R, Kunick C.

Molecules. 2016 Feb 17;21(2). pii: E223. doi: 10.3390/molecules21020223.

15.

Selective inhibitors of Plasmodium falciparum glycogen synthase-3 (PfGSK-3): New antimalarial agents?

Masch A, Kunick C.

Biochim Biophys Acta. 2015 Oct;1854(10 Pt B):1644-9. doi: 10.1016/j.bbapap.2015.03.013. Epub 2015 Apr 7. Review.

PMID:
25861860
16.

10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A.

Falke H, Chaikuad A, Becker A, Loaëc N, Lozach O, Abu Jhaisha S, Becker W, Jones PG, Preu L, Baumann K, Knapp S, Meijer L, Kunick C.

J Med Chem. 2015 Apr 9;58(7):3131-43. doi: 10.1021/jm501994d. Epub 2015 Mar 23.

17.

9- and 11-Substituted 4-azapaullones are potent and selective inhibitors of African trypanosoma.

Maiwald F, Benítez D, Charquero D, Dar MA, Erdmann H, Preu L, Koch O, Hölscher C, Loaëc N, Meijer L, Comini MA, Kunick C.

Eur J Med Chem. 2014 Aug 18;83:274-83. doi: 10.1016/j.ejmech.2014.06.020. Epub 2014 Jun 11.

PMID:
24973661
18.

Synthesis and properties of a selective inhibitor of homeodomain-interacting protein kinase 2 (HIPK2).

Cozza G, Zanin S, Determann R, Ruzzene M, Kunick C, Pinna LA.

PLoS One. 2014 Feb 24;9(2):e89176. doi: 10.1371/journal.pone.0089176. eCollection 2014.

19.

2-Arylpaullones are selective antitrypanosomal agents.

Ryczak J, Papini M, Lader A, Nasereddin A, Kopelyanskiy D, Preu L, Jaffe CL, Kunick C.

Eur J Med Chem. 2013 Jun;64:396-400. doi: 10.1016/j.ejmech.2013.03.065. Epub 2013 Apr 10.

PMID:
23648975
20.

Parenteral formulation of an antileishmanial drug candidate--tackling poor solubility, chemical instability, and polymorphism.

Kupetz E, Preu L, Kunick C, Bunjes H.

Eur J Pharm Biopharm. 2013 Nov;85(3 Pt A):511-20. doi: 10.1016/j.ejpb.2013.02.001. Epub 2013 Feb 26.

PMID:
23454203

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