Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 20 of 94

1.

Cysteine proteases during larval migration and development of helminths in their final host.

Grote A, Caffrey CR, Rebello KM, Smith D, Dalton JP, Lustigman S.

PLoS Negl Trop Dis. 2018 Aug 23;12(8):e0005919. doi: 10.1371/journal.pntd.0005919. eCollection 2018 Aug. Review.

2.

Cysteine proteases as digestive enzymes in parasitic helminths.

Caffrey CR, Goupil L, Rebello KM, Dalton JP, Smith D.

PLoS Negl Trop Dis. 2018 Aug 23;12(8):e0005840. doi: 10.1371/journal.pntd.0005840. eCollection 2018 Aug. Review.

3.

Effect of Phenotypic Screening of Extracts and Fractions of Erythrophleum ivorense Leaf and Stem Bark on Immature and Adult Stages of Schistosoma mansoni.

Kyere-Davies G, Agyare C, Boakye YD, Suzuki BM, Caffrey CR.

J Parasitol Res. 2018 Jun 7;2018:9431467. doi: 10.1155/2018/9431467. eCollection 2018.

4.

Brain-Penetrant Triazolopyrimidine and Phenylpyrimidine Microtubule Stabilizers as Potential Leads to Treat Human African Trypanosomiasis.

Monti L, Wang SC, Oukoloff K, Smith AB 3rd, Brunden KR, Caffrey CR, Ballatore C.

ChemMedChem. 2018 Sep 6;13(17):1751-1754. doi: 10.1002/cmdc.201800404. Epub 2018 Aug 7.

PMID:
29969537
5.

Octopamine signaling in the metazoan pathogen Schistosoma mansoni: localization, small-molecule screening and opportunities for drug development.

El-Sakkary N, Chen S, Arkin MR, Caffrey CR, Ribeiro P.

Dis Model Mech. 2018 Jul 30;11(7). pii: dmm033563. doi: 10.1242/dmm.033563.

6.

Substrate Specificity of Cysteine Proteases Beyond the S2 Pocket: Mutagenesis and Molecular Dynamics Investigation of Fasciola hepatica Cathepsins L.

Corvo I, Ferraro F, Merlino A, Zuberbühler K, O'Donoghue AJ, Pastro L, Pi-Denis N, Basika T, Roche L, McKerrow JH, Craik CS, Caffrey CR, Tort JF.

Front Mol Biosci. 2018 Apr 19;5:40. doi: 10.3389/fmolb.2018.00040. eCollection 2018.

7.

SmSP2: A serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties.

Leontovyč A, Ulrychová L, O'Donoghue AJ, Vondrášek J, Marešová L, Hubálek M, Fajtová P, Chanová M, Jiang Z, Craik CS, Caffrey CR, Mareš M, Dvořák J, Horn M.

PLoS Negl Trop Dis. 2018 Apr 20;12(4):e0006446. doi: 10.1371/journal.pntd.0006446. eCollection 2018 Apr.

8.

Sertraline, Paroxetine, and Chlorpromazine Are Rapidly Acting Anthelmintic Drugs Capable of Clinical Repurposing.

Weeks JC, Roberts WM, Leasure C, Suzuki BM, Robinson KJ, Currey H, Wangchuk P, Eichenberger RM, Saxton AD, Bird TD, Kraemer BC, Loukas A, Hawdon JM, Caffrey CR, Liachko NF.

Sci Rep. 2018 Jan 17;8(1):975. doi: 10.1038/s41598-017-18457-w.

9.

Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target.

Long T, Rojo-Arreola L, Shi D, El-Sakkary N, Jarnagin K, Rock F, Meewan M, Rascón AA Jr, Lin L, Cunningham KA, Lemieux GA, Podust L, Abagyan R, Ashrafi K, McKerrow JH, Caffrey CR.

PLoS Negl Trop Dis. 2017 Jul 13;11(7):e0005680. doi: 10.1371/journal.pntd.0005680. eCollection 2017 Jul.

10.

Targeting proteasomes in infectious organisms to combat disease.

Bibo-Verdugo B, Jiang Z, Caffrey CR, O'Donoghue AJ.

FEBS J. 2017 May;284(10):1503-1517. doi: 10.1111/febs.14029. Epub 2017 Feb 16. Review.

11.

Anthelmintics: From discovery to resistance II (San Diego, 2016).

Martin RJ, Wolstenholme AJ, Caffrey CR.

Int J Parasitol Drugs Drug Resist. 2016 Dec;6(3):297-298. doi: 10.1016/j.ijpddr.2016.09.002. Epub 2016 Sep 29.

12.

Sex-Biased Transcriptome of Schistosoma mansoni: Host-Parasite Interaction, Genetic Determinants and Epigenetic Regulators Are Associated with Sexual Differentiation.

Picard MA, Boissier J, Roquis D, Grunau C, Allienne JF, Duval D, Toulza E, Arancibia N, Caffrey CR, Long T, Nidelet S, Rohmer M, Cosseau C.

PLoS Negl Trop Dis. 2016 Sep 27;10(9):e0004930. doi: 10.1371/journal.pntd.0004930. eCollection 2016 Sep.

13.

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Van Voorhis WC, Adams JH, Adelfio R, Ahyong V, Akabas MH, Alano P, Alday A, Alemán Resto Y, Alsibaee A, Alzualde A, Andrews KT, Avery SV, Avery VM, Ayong L, Baker M, Baker S, Ben Mamoun C, Bhatia S, Bickle Q, Bounaadja L, Bowling T, Bosch J, Boucher LE, Boyom FF, Brea J, Brennan M, Burton A, Caffrey CR, Camarda G, Carrasquilla M, Carter D, Belen Cassera M, Chih-Chien Cheng K, Chindaudomsate W, Chubb A, Colon BL, Colón-López DD, Corbett Y, Crowther GJ, Cowan N, D'Alessandro S, Le Dang N, Delves M, DeRisi JL, Du AY, Duffy S, Abd El-Salam El-Sayed S, Ferdig MT, Fernández Robledo JA, Fidock DA, Florent I, Fokou PV, Galstian A, Gamo FJ, Gokool S, Gold B, Golub T, Goldgof GM, Guha R, Guiguemde WA, Gural N, Guy RK, Hansen MA, Hanson KK, Hemphill A, Hooft van Huijsduijnen R, Horii T, Horrocks P, Hughes TB, Huston C, Igarashi I, Ingram-Sieber K, Itoe MA, Jadhav A, Naranuntarat Jensen A, Jensen LT, Jiang RH, Kaiser A, Keiser J, Ketas T, Kicka S, Kim S, Kirk K, Kumar VP, Kyle DE, Lafuente MJ, Landfear S, Lee N, Lee S, Lehane AM, Li F, Little D, Liu L, Llinás M, Loza MI, Lubar A, Lucantoni L, Lucet I, Maes L, Mancama D, Mansour NR, March S, McGowan S, Medina Vera I, Meister S, Mercer L, Mestres J, Mfopa AN, Misra RN, Moon S, Moore JP, Morais Rodrigues da Costa F, Müller J, Muriana A, Nakazawa Hewitt S, Nare B, Nathan C, Narraidoo N, Nawaratna S, Ojo KK, Ortiz D, Panic G, Papadatos G, Parapini S, Patra K, Pham N, Prats S, Plouffe DM, Poulsen SA, Pradhan A, Quevedo C, Quinn RJ, Rice CA, Abdo Rizk M, Ruecker A, St Onge R, Salgado Ferreira R, Samra J, Robinett NG, Schlecht U, Schmitt M, Silva Villela F, Silvestrini F, Sinden R, Smith DA, Soldati T, Spitzmüller A, Stamm SM, Sullivan DJ, Sullivan W, Suresh S, Suzuki BM, Suzuki Y, Swamidass SJ, Taramelli D, Tchokouaha LR, Theron A, Thomas D, Tonissen KF, Townson S, Tripathi AK, Trofimov V, Udenze KO, Ullah I, Vallieres C, Vigil E, Vinetz JM, Voong Vinh P, Vu H, Watanabe NA, Weatherby K, White PM, Wilks AF, Winzeler EA, Wojcik E, Wree M, Wu W, Yokoyama N, Zollo PH, Abla N, Blasco B, Burrows J, Laleu B, Leroy D, Spangenberg T, Wells T, Willis PA.

PLoS Pathog. 2016 Jul 28;12(7):e1005763. doi: 10.1371/journal.ppat.1005763. eCollection 2016 Jul.

14.

Odanacatib, a Cathepsin K Cysteine Protease Inhibitor, Kills Hookworm In Vivo.

Vermeire JJ, Suzuki BM, Caffrey CR.

Pharmaceuticals (Basel). 2016 Jul 4;9(3). pii: E39. doi: 10.3390/ph9030039.

15.

Algorithmic Mapping and Characterization of the Drug-Induced Phenotypic-Response Space of Parasites Causing Schistosomiasis.

Singh R, Beasley R, Long T, Caffrey CR.

IEEE/ACM Trans Comput Biol Bioinform. 2018 Mar-Apr;15(2):469-481. doi: 10.1109/TCBB.2016.2550444. Epub 2016 Apr 7.

PMID:
27071187
16.

Evaluation of the CCA Immuno-Chromatographic Test to Diagnose Schistosoma mansoni in Minas Gerais State, Brazil.

Silveira AM, Costa EG, Ray D, Suzuki BM, Hsieh MH, Fraga LA, Caffrey CR.

PLoS Negl Trop Dis. 2016 Jan 11;10(1):e0004357. doi: 10.1371/journal.pntd.0004357. eCollection 2016 Jan.

17.

Structure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoni.

Long T, Neitz RJ, Beasley R, Kalyanaraman C, Suzuki BM, Jacobson MP, Dissous C, McKerrow JH, Drewry DH, Zuercher WJ, Singh R, Caffrey CR.

PLoS Negl Trop Dis. 2016 Jan 11;10(1):e0004356. doi: 10.1371/journal.pntd.0004356. eCollection 2016 Jan.

18.

Excretion/secretion products from Schistosoma mansoni adults, eggs and schistosomula have unique peptidase specificity profiles.

Dvořák J, Fajtová P, Ulrychová L, Leontovyč A, Rojo-Arreola L, Suzuki BM, Horn M, Mareš M, Craik CS, Caffrey CR, O'Donoghue AJ.

Biochimie. 2016 Mar;122:99-109. doi: 10.1016/j.biochi.2015.09.025. Epub 2015 Sep 26.

19.

Caenorhabditis elegans is a useful model for anthelmintic discovery.

Burns AR, Luciani GM, Musso G, Bagg R, Yeo M, Zhang Y, Rajendran L, Glavin J, Hunter R, Redman E, Stasiuk S, Schertzberg M, Angus McQuibban G, Caffrey CR, Cutler SR, Tyers M, Giaever G, Nislow C, Fraser AG, MacRae CA, Gilleard J, Roy PJ.

Nat Commun. 2015 Jun 25;6:7485. doi: 10.1038/ncomms8485.

20.

Anti-Schistosomal Activity of Cinnamic Acid Esters: Eugenyl and Thymyl Cinnamate Induce Cytoplasmic Vacuoles and Death in Schistosomula of Schistosoma mansoni.

Glaser J, Schurigt U, Suzuki BM, Caffrey CR, Holzgrabe U.

Molecules. 2015 Jun 12;20(6):10873-83. doi: 10.3390/molecules200610873.

Supplemental Content

Loading ...
Support Center