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Items: 1 to 20 of 31

1.

Rabies in the Caribbean: A Situational Analysis and Historic Review.

Seetahal JFR, Vokaty A, Vigilato MAN, Carrington CVF, Pradel J, Louison B, Sauers AV, Roopnarine R, Arrebato JCG, Millien MF, James C, Rupprecht CE.

Trop Med Infect Dis. 2018 Aug 20;3(3). pii: E89. doi: 10.3390/tropicalmed3030089.

2.

The culture of pretence: a hidden barrier to recognising, disclosing and ending domestic violence.

Francis L, Loxton D, James C.

J Clin Nurs. 2017 Aug;26(15-16):2202-2214. doi: 10.1111/jocn.13501. Epub 2017 Feb 23.

PMID:
27504594
3.

Thromboxane A2 receptor (TBXA2R) is a potent survival factor for triple negative breast cancers (TNBCs).

Orr K, Buckley NE, Haddock P, James C, Parent JL, McQuaid S, Mullan PB.

Oncotarget. 2016 Aug 23;7(34):55458-55472. doi: 10.18632/oncotarget.10969.

4.

Synthesis, anti-mycobacterial activity and DNA sequence-selectivity of a library of biaryl-motifs containing polyamides.

Brucoli F, Guzman JD, Maitra A, James CH, Fox KR, Bhakta S.

Bioorg Med Chem. 2015 Jul 1;23(13):3705-11. doi: 10.1016/j.bmc.2015.04.001. Epub 2015 Apr 8.

PMID:
25921267
5.

Effect of hairpin loop structure on reactivity, sequence preference and adduct orientation of a DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumour agent.

Thurston DE, Vassoler H, Jackson PJ, James CH, Rahman KM.

Org Biomol Chem. 2015 Apr 7;13(13):4031-40. doi: 10.1039/c4ob02405b.

PMID:
25733051
6.

Computational studies support the role of the C7-sibirosamine sugar of the pyrrolobenzodiazepine (PBD) sibiromycin in transcription factor inhibition.

Jackson PJ, James CH, Jenkins TC, Rahman KM, Thurston DE.

ACS Chem Biol. 2014 Oct 17;9(10):2432-40. doi: 10.1021/cb5002203. Epub 2014 Aug 11.

PMID:
25111266
7.

Determining the community prevalence of acute gastrointestinal illness and gaps in surveillance of acute gastroenteritis and foodborne diseases in Guyana.

Persuad S, Mohamed-Rambaran P, Wilson A, James C, Indar L.

J Health Popul Nutr. 2013 Dec;31(4 Suppl 1):57-68.

PMID:
24992812
8.

Identification and validation of an anthracycline/cyclophosphamide-based chemotherapy response assay in breast cancer.

Mulligan JM, Hill LA, Deharo S, Irwin G, Boyle D, Keating KE, Raji OY, McDyer FA, O'Brien E, Bylesjo M, Quinn JE, Lindor NM, Mullan PB, James CR, Walker SM, Kerr P, James J, Davison TS, Proutski V, Salto-Tellez M, Johnston PG, Couch FJ, Paul Harkin D, Kennedy RD.

J Natl Cancer Inst. 2014 Jan;106(1):djt335. doi: 10.1093/jnci/djt335.

9.

An extended pyrrolobenzodiazepine-polyamide conjugate with selectivity for a DNA sequence containing the ICB2 transcription factor binding site.

Brucoli F, Hawkins RM, James CH, Jackson PJ, Wells G, Jenkins TC, Ellis T, Kotecha M, Hochhauser D, Hartley JA, Howard PW, Thurston DE.

J Med Chem. 2013 Aug 22;56(16):6339-51. doi: 10.1021/jm4001852. Epub 2013 Jul 26.

PMID:
23889553
10.

GC-targeted C8-linked pyrrolobenzodiazepine-biaryl conjugates with femtomolar in vitro cytotoxicity and in vivo antitumor activity in mouse models.

Rahman KM, Jackson PJ, James CH, Basu BP, Hartley JA, de la Fuente M, Schatzlein A, Robson M, Pedley RB, Pepper C, Fox KR, Howard PW, Thurston DE.

J Med Chem. 2013 Apr 11;56(7):2911-35. doi: 10.1021/jm301882a. Epub 2013 Mar 21.

PMID:
23514599
11.

Antistaphylococcal activity of DNA-interactive pyrrolobenzodiazepine (PBD) dimers and PBD-biaryl conjugates.

Rahman KM, Rosado H, Moreira JB, Feuerbaum EA, Fox KR, Stecher E, Howard PW, Gregson SJ, James CH, de la Fuente M, Waldron DE, Thurston DE, Taylor PW.

J Antimicrob Chemother. 2012 Jul;67(7):1683-96. doi: 10.1093/jac/dks127. Epub 2012 Apr 30.

12.

Observation of a single-stranded DNA/pyrrolobenzodiazepine adduct.

Rahman KM, James CH, Bui TT, Drake AF, Thurston DE.

J Am Chem Soc. 2011 Dec 7;133(48):19376-85. doi: 10.1021/ja205395r. Epub 2011 Nov 9.

PMID:
21928841
13.

Human epidermal growth factor receptor 2-positive breast cancer relapsing post-adjuvant trastuzumab: pattern of recurrence, treatment and outcome.

Krell J, James CR, Shah D, Gojis O, Lim A, Riddle P, Ahmad R, Makris A, Cowdray A, Chow A, Babayev T, Madden P, Leonard R, Cleator S, Palmieri C.

Clin Breast Cancer. 2011 Jun;11(3):153-60. doi: 10.1016/j.clbc.2011.03.012. Epub 2011 Apr 20.

PMID:
21665135
14.

Novel C8-linked pyrrolobenzodiazepine (PBD)-heterocycle conjugates that recognize DNA sequences containing an inverted CCAAT box.

Brucoli F, Hawkins RM, James CH, Wells G, Jenkins TC, Ellis T, Hartley JA, Howard PW, Thurston DE.

Bioorg Med Chem Lett. 2011 Jun 15;21(12):3780-3. doi: 10.1016/j.bmcl.2011.04.054. Epub 2011 Apr 20.

PMID:
21570842
15.

Effect of base sequence on the DNA cross-linking properties of pyrrolobenzodiazepine (PBD) dimers.

Rahman KM, James CH, Thurston DE.

Nucleic Acids Res. 2011 Jul;39(13):5800-12. doi: 10.1093/nar/gkr122. Epub 2011 Mar 21.

16.

Observation of the reversibility of a covalent pyrrolobenzodiazepine (PBD) DNA adduct by HPLC/MS and CD spectroscopy.

Rahman KM, James CH, Thurston DE.

Org Biomol Chem. 2011 Mar 7;9(5):1632-41. doi: 10.1039/c0ob00762e. Epub 2011 Jan 21.

PMID:
21253653
17.

DNA Sequence Preference and Adduct Orientation of Pyrrolo[2,1-c][1,4]benzodiazepine Antitumor Agents.

Rahman KM, Vassoler H, James CH, Thurston DE.

ACS Med Chem Lett. 2010 Aug 13;1(8):427-32. doi: 10.1021/ml100131b. eCollection 2010 Nov 11.

18.

Rechallenging with anthracyclines and taxanes in metastatic breast cancer.

Palmieri C, Krell J, James CR, Harper-Wynne C, Misra V, Cleator S, Miles D.

Nat Rev Clin Oncol. 2010 Oct;7(10):561-74. doi: 10.1038/nrclinonc.2010.122. Epub 2010 Aug 31. Review.

PMID:
20808300
19.

Structure-activity relationships of monomeric C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumor agents.

Antonow D, Kaliszczak M, Kang GD, Coffils M, Tiberghien AC, Cooper N, Barata T, Heidelberger S, James CH, Zloh M, Jenkins TC, Reszka AP, Neidle S, Guichard SM, Jodrell DI, Hartley JA, Howard PW, Thurston DE.

J Med Chem. 2010 Apr 8;53(7):2927-41. doi: 10.1021/jm901722v.

PMID:
20218628
20.

BRCA1 transcriptionally regulates genes associated with the basal-like phenotype in breast cancer.

Gorski JJ, James CR, Quinn JE, Stewart GE, Staunton KC, Buckley NE, McDyer FA, Kennedy RD, Wilson RH, Mullan PB, Harkin DP.

Breast Cancer Res Treat. 2010 Aug;122(3):721-31. doi: 10.1007/s10549-009-0565-0. Epub 2009 Oct 31.

PMID:
19882246

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