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Items: 1 to 20 of 52

1.

The use of Sulfonamide Derivatives in the Treatment of Trypanosomatid Parasites, Including Trypanosoma cruzi, Trypanosoma brucei, and Leishmania ssp.

Scarim CB, Chelucci RC, Dos Santos JL, Chin CM.

Med Chem. 2019 Jun 20. doi: 10.2174/1573406415666190620141109. [Epub ahead of print]

PMID:
31218962
2.

Thiazole, thio and semicarbazone derivatives against tropical infective diseases: Chagas disease, human African trypanosomiasis (HAT), leishmaniasis, and malaria.

Scarim CB, Jornada DH, Machado MGM, Ferreira CMR, Dos Santos JL, Chung MC.

Eur J Med Chem. 2019 Jan 15;162:378-395. doi: 10.1016/j.ejmech.2018.11.013. Epub 2018 Nov 12. Review.

PMID:
30453246
3.

Current advances in drug discovery for Chagas disease.

Scarim CB, Jornada DH, Chelucci RC, de Almeida L, Dos Santos JL, Chung MC.

Eur J Med Chem. 2018 Jul 15;155:824-838. doi: 10.1016/j.ejmech.2018.06.040. Epub 2018 Jun 20. Review.

PMID:
30033393
4.

Discovery of phenylsulfonylfuroxan derivatives as gamma globin inducers by histone acetylation.

Melo TRF, Kumkhaek C, Fernandes GFDS, Lopes Pires ME, Chelucci RC, Barbieri KP, Coelho F, Capote TSO, Lanaro C, Carlos IZ, Marcondes S, Chegaev K, Guglielmo S, Fruttero R, Chung MC, Costa FF, Rodgers GP, Dos Santos JL.

Eur J Med Chem. 2018 Jun 25;154:341-353. doi: 10.1016/j.ejmech.2018.05.008. Epub 2018 May 30.

PMID:
29852459
5.

Response to different benznidazole doses in animal models of chronic phase Chagas disease: a critical review.

Scarim CB, Ribeiro AR, Rosa JAD, Chin CM.

Rev Soc Bras Med Trop. 2018 Mar-Apr;51(2):133-140. doi: 10.1590/0037-8682-0337-2017. Review.

6.

A thalidomide-hydroxyurea hybrid increases HbF production in sickle cell mice and reduces the release of proinflammatory cytokines in cultured monocytes.

Lanaro C, Franco-Penteado CF, Silva FH, Fertrin KY, Dos Santos JL, Wade M, Yerigenahally S, de Melo TR, Chin CM, Kutlar A, Meiler SE, Costa FF.

Exp Hematol. 2018 Feb;58:35-38. doi: 10.1016/j.exphem.2017.10.003. Epub 2017 Nov 3.

PMID:
29108926
7.

Epigenetic Regulatory Mechanisms Induced by Resveratrol.

Fernandes GFS, Silva GDB, Pavan AR, Chiba DE, Chin CM, Dos Santos JL.

Nutrients. 2017 Nov 1;9(11). pii: E1201. doi: 10.3390/nu9111201. Review.

8.

Dietary Compound Resveratrol Is a Pan-BET Bromodomain Inhibitor.

Dutra LA, Heidenreich D, Silva GDBD, Man Chin C, Knapp S, Santos JLD.

Nutrients. 2017 Oct 27;9(11). pii: E1172. doi: 10.3390/nu9111172.

9.

Design, Synthesis, and Characterization of N-Oxide-Containing Heterocycles with in Vivo Sterilizing Antitubercular Activity.

Dos Santos Fernandes GF, de Souza PC, Moreno-Viguri E, Santivañez-Veliz M, Paucar R, Pérez-Silanes S, Chegaev K, Guglielmo S, Lazzarato L, Fruttero R, Man Chin C, da Silva PB, Chorilli M, Solcia MC, Ribeiro CM, Silva CSP, Marino LB, Bosquesi PL, Hunt DM, de Carvalho LPS, de Souza Costa CA, Cho SH, Wang Y, Franzblau SG, Pavan FR, Dos Santos JL.

J Med Chem. 2017 Oct 26;60(20):8647-8660. doi: 10.1021/acs.jmedchem.7b01332. Epub 2017 Oct 16.

10.

Advances in Drug Discovery of New Antitubercular Multidrug-Resistant Compounds.

Fernandes GFDS, Man Chin C, Dos Santos JL.

Pharmaceuticals (Basel). 2017 Jun 1;10(2). pii: E51. doi: 10.3390/ph10020051. Review.

11.

Targeting Leishmania amazonensis amastigotes through macrophage internalisation of a hydroxymethylnitrofurazone nanostructured polymeric system.

Monteiro LM, Löbenberg R, Ferreira EI, Cotrim PC, Kanashiro E, Rocha M, Chung MC, Bou-Chacra N.

Int J Antimicrob Agents. 2017 Jul;50(1):88-92. doi: 10.1016/j.ijantimicag.2017.01.033. Epub 2017 Apr 26.

PMID:
28454918
12.

Synthesis, antiplatelet and antithrombotic activities of resveratrol derivatives with NO-donor properties.

Dutra LA, Guanaes JFO, Johmann N, Lopes Pires ME, Chin CM, Marcondes S, Dos Santos JL.

Bioorg Med Chem Lett. 2017 Jun 1;27(11):2450-2453. doi: 10.1016/j.bmcl.2017.04.007. Epub 2017 Apr 4.

PMID:
28400236
13.

Unraveling the Anticancer Effect of Curcumin and Resveratrol.

Pavan AR, Silva GD, Jornada DH, Chiba DE, Fernandes GF, Man Chin C, Dos Santos JL.

Nutrients. 2016 Nov 10;8(11). pii: E628. Review.

14.

Synthesis and biological activity of furoxan derivatives against Mycobacterium tuberculosis.

Fernandes GFDS, de Souza PC, Marino LB, Chegaev K, Guglielmo S, Lazzarato L, Fruttero R, Chung MC, Pavan FR, Dos Santos JL.

Eur J Med Chem. 2016 Nov 10;123:523-531. doi: 10.1016/j.ejmech.2016.07.039. Epub 2016 Jul 21.

PMID:
27508879
15.

The Prodrug Approach: A Successful Tool for Improving Drug Solubility.

Jornada DH, dos Santos Fernandes GF, Chiba DE, de Melo TR, dos Santos JL, Chung MC.

Molecules. 2015 Dec 29;21(1):42. doi: 10.3390/molecules21010042. Review.

16.

Synthesis and Preliminary Evaluation of N-Oxide Derivatives for the Prevention of Atherothrombotic Events.

Rosseto LA, Pires ME, Melchior AC, Bosquesi PL, Pavan AR, Marcondes S, Chung MC, Santos JL.

Molecules. 2015 Oct 7;20(10):18185-200. doi: 10.3390/molecules201018185.

17.

Tuberculosis: Challenges to Improve the Treatment.

Lima MM, Trindade A, Carnavalli F, Bolognesi Melchior AC, Chin CM, Dos Santos JL.

Curr Clin Pharmacol. 2015;10(3):242-51. Review.

PMID:
26338175
18.

Current Advances in Antitubercular Drug Discovery: Potent Prototypes and New Targets.

Dos Santos Fernandes GF, Jornada DH, de Souza PC, Chin CM, Pavan FR, Dos Santos JL.

Curr Med Chem. 2015;22(27):3133-61. Review.

PMID:
26282941
19.

Challenges to the Treatment and New Perspectives for the Eradication of Helicobacter pylori.

Yazbek PB, Trindade AB, Chin CM, Dos Santos JL.

Dig Dis Sci. 2015 Oct;60(10):2901-12. doi: 10.1007/s10620-015-3712-y. Epub 2015 May 22. Review.

PMID:
25999247
20.

Evaluation of antimalarial activity and toxicity of a new primaquine prodrug.

Davanço MG, Aguiar AC, Dos Santos LA, Padilha EC, Campos ML, de Andrade CR, da Fonseca LM, Dos Santos JL, Chin CM, Krettli AU, Peccinini RG.

PLoS One. 2014 Aug 18;9(8):e105217. doi: 10.1371/journal.pone.0105217. eCollection 2014.

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