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Items: 19

1.

Towards the Development of an In vivo Chemical Probe for Cyclin G Associated Kinase (GAK).

Asquith CRM, Bennett JM, Su L, Laitinen T, Elkins JM, Pickett JE, Wells CI, Li Z, Willson TM, Zuercher WJ.

Molecules. 2019 Nov 6;24(22). pii: E4016. doi: 10.3390/molecules24224016.

2.

Design and Analysis of the 4-Anilinoquin(az)oline Kinase Inhibition Profiles of GAK/SLK/STK10 Using Quantitative Structure-Activity Relationships.

Asquith CRM, Laitinen T, Bennett JM, Wells CI, Elkins JM, Zuercher WJ, Tizzard GJ, Poso A.

ChemMedChem. 2019 Nov 1. doi: 10.1002/cmdc.201900521. [Epub ahead of print]

PMID:
31675459
3.

ADCK3/COQ8A: the choice target of the UbiB protein kinase-like family.

Asquith CRM, Murray NH, Pagliarini DJ.

Nat Rev Drug Discov. 2019 Oct;18(11):815. doi: 10.1038/d41573-019-00158-w. No abstract available.

PMID:
31673128
4.

Quinazoline-based anti-virulence compounds selectively target Salmonella PhoP/PhoQ signal transduction system.

Carabajal MA, Asquith CRM, Laitinen T, Tizzard GJ, Yim L, Rial A, Chabalgoity JA, Zuercher WJ, García Véscovi E.

Antimicrob Agents Chemother. 2019 Oct 14. pii: AAC.01744-19. doi: 10.1128/AAC.01744-19. [Epub ahead of print]

PMID:
31611347
5.

Targeting an EGFR Water Network with 4-Anilinoquin(az)oline Inhibitors for Chordoma.

Asquith CRM, Maffuid KA, Laitinen T, Torrice CD, Tizzard GJ, Crona DJ, Zuercher WJ.

ChemMedChem. 2019 Oct 4;14(19):1693-1700. doi: 10.1002/cmdc.201900428. Epub 2019 Sep 23.

PMID:
31424613
6.

Novel epidithiodiketopiperazines as anti-viral zinc ejectors of the Feline Immunodeficiency Virus (FIV) nucleocapsid protein as a model for HIV infection.

Asquith CRM, Sil BC, Laitinen T, Tizzard GJ, Coles SJ, Poso A, Hofmann-Lehmann R, Hilton ST.

Bioorg Med Chem. 2019 Sep 15;27(18):4174-4184. doi: 10.1016/j.bmc.2019.07.047. Epub 2019 Jul 30.

PMID:
31395510
7.

Anti-tubercular activity of novel 4-anilinoquinolines and 4-anilinoquinazolines.

Asquith CRM, Fleck N, Torrice CD, Crona DJ, Grundner C, Zuercher WJ.

Bioorg Med Chem Lett. 2019 Sep 15;29(18):2695-2699. doi: 10.1016/j.bmcl.2019.07.012. Epub 2019 Jul 10.

PMID:
31378571
8.

RIOK2: straddling the kinase/ATPase line.

Asquith CRM, East MP, Zuercher WJ.

Nat Rev Drug Discov. 2019 Jul;18(8):574. doi: 10.1038/d41573-019-00107-7. No abstract available.

PMID:
31367048
9.

Utilizing comprehensive and mini-kinome panels to optimize the selectivity of quinoline inhibitors for cyclin G associated kinase (GAK).

Asquith CRM, Treiber DK, Zuercher WJ.

Bioorg Med Chem Lett. 2019 Jul 15;29(14):1727-1731. doi: 10.1016/j.bmcl.2019.05.025. Epub 2019 May 16.

10.

Synthesis and comparison of substituted 1,2,3-dithiazole and 1,2,3-thiaselenazole as inhibitors of the feline immunodeficiency virus (FIV) nucleocapsid protein as a model for HIV infection.

Asquith CRM, Meili T, Laitinen T, Baranovsky IV, Konstantinova LS, Poso A, Rakitin OA, Hofmann-Lehmann R.

Bioorg Med Chem Lett. 2019 Jul 15;29(14):1765-1768. doi: 10.1016/j.bmcl.2019.05.016. Epub 2019 May 9.

PMID:
31101470
11.

Design of a Cyclin G Associated Kinase (GAK)/Epidermal Growth Factor Receptor (EGFR) Inhibitor Set to Interrogate the Relationship of EGFR and GAK in Chordoma.

Asquith CRM, Naegeli KM, East MP, Laitinen T, Havener TM, Wells CI, Johnson GL, Drewry DH, Zuercher WJ, Morris DC.

J Med Chem. 2019 May 9;62(9):4772-4778. doi: 10.1021/acs.jmedchem.9b00350. Epub 2019 Apr 19.

PMID:
30973735
12.

SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK).

Asquith CRM, Berger BT, Wan J, Bennett JM, Capuzzi SJ, Crona DJ, Drewry DH, East MP, Elkins JM, Fedorov O, Godoi PH, Hunter DM, Knapp S, Müller S, Torrice CD, Wells CI, Earp HS, Willson TM, Zuercher WJ.

J Med Chem. 2019 Mar 14;62(5):2830-2836. doi: 10.1021/acs.jmedchem.8b01213. Epub 2019 Feb 26.

13.

Investigation of the Pentathiepin Functionality as an Inhibitor of Feline Immunodeficiency Virus (FIV) via a Potential Zinc Ejection Mechanism, as a Model for HIV Infection.

Asquith CRM, Laitinen T, Konstantinova LS, Tizzard G, Poso A, Rakitin OA, Hofmann-Lehmann R, Hilton ST.

ChemMedChem. 2019 Feb 19;14(4):454-461. doi: 10.1002/cmdc.201800718. Epub 2019 Jan 25.

PMID:
30609219
14.

Identification of lead anti-human cytomegalovirus compounds targeting MAP4K4 via machine learning analysis of kinase inhibitor screening data.

Strang BL, Asquith CRM, Moshrif HF, Ho CM, Zuercher WJ, Al-Ali H.

PLoS One. 2018 Jul 26;13(7):e0201321. doi: 10.1371/journal.pone.0201321. eCollection 2018.

15.

1,2,6-Thiadiazinones as Novel Narrow Spectrum Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) Inhibitors.

Asquith CRM, Godoi PH, Couñago RM, Laitinen T, Scott JW, Langendorf CG, Oakhill JS, Drewry DH, Zuercher WJ, Koutentis PA, Willson TM, Kalogirou AS.

Molecules. 2018 May 19;23(5). pii: E1221. doi: 10.3390/molecules23051221.

16.

Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase.

Asquith CRM, Laitinen T, Bennett JM, Godoi PH, East MP, Tizzard GJ, Graves LM, Johnson GL, Dornsife RE, Wells CI, Elkins JM, Willson TM, Zuercher WJ.

ChemMedChem. 2018 Jan 8;13(1):48-66. doi: 10.1002/cmdc.201700663. Epub 2017 Nov 27.

17.

Evaluation of Substituted 1,2,3-Dithiazoles as Inhibitors of the Feline Immunodeficiency Virus (FIV) Nucleocapsid Protein via a Proposed Zinc Ejection Mechanism.

Asquith CR, Konstantinova LS, Laitinen T, Meli ML, Poso A, Rakitin OA, Hofmann-Lehmann R, Hilton ST.

ChemMedChem. 2016 Oct 6;11(19):2119-2126. doi: 10.1002/cmdc.201600260. Epub 2016 Aug 11.

PMID:
27511289
18.

Novel fused tetrathiocines as antivirals that target the nucleocapsid zinc finger containing protein of the feline immunodeficiency virus (FIV) as a model of HIV infection.

Asquith CR, Meli ML, Konstantinova LS, Laitinen T, Poso A, Rakitin OA, Hofmann-Lehmann R, Allenspach K, Hilton ST.

Bioorg Med Chem Lett. 2015 Mar 15;25(6):1352-5. doi: 10.1016/j.bmcl.2014.12.047. Epub 2014 Dec 20.

19.

Evaluation of the antiviral efficacy of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives against the nucelocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV infection.

Asquith CR, Meli ML, Konstantinova LS, Laitinen T, Peräkylä M, Poso A, Rakitin OA, Allenspach K, Hofmann-Lehmann R, Hilton ST.

Bioorg Med Chem Lett. 2014 Jun 15;24(12):2640-4. doi: 10.1016/j.bmcl.2014.04.073. Epub 2014 Apr 26.

PMID:
24813732

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