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Items: 18


Repurposing the Electron Transfer Reactant Phenazine Methosulfate (PMS) for the Apoptotic Elimination of Malignant Melanoma Cells through Induction of Lethal Oxidative and Mitochondriotoxic Stress.

Hua AB, Justiniano R, Perer J, Park SL, Li H, Cabello CM, Wondrak GT.

Cancers (Basel). 2019 Apr 27;11(5). pii: E590. doi: 10.3390/cancers11050590.


A Topical Zinc Ionophore Blocks Tumorigenic Progression in UV-exposed SKH-1 High-risk Mouse Skin.

Justiniano R, Perer J, Hua A, Fazel M, Krajisnik A, Cabello CM, Wondrak GT.

Photochem Photobiol. 2017 Nov;93(6):1472-1482. doi: 10.1111/php.12794. Epub 2017 Jul 21.


The quinone methide aurin is a heat shock response inducer that causes proteotoxic stress and Noxa-dependent apoptosis in malignant melanoma cells.

Davis AL, Qiao S, Lesson JL, Rojo de la Vega M, Park SL, Seanez CM, Gokhale V, Cabello CM, Wondrak GT.

J Biol Chem. 2015 Jan 16;290(3):1623-38. doi: 10.1074/jbc.M114.592626. Epub 2014 Dec 4.


The Tryptophan-Derived Endogenous Aryl Hydrocarbon Receptor Ligand 6-Formylindolo[3,2-b]Carbazole Is a Nanomolar UVA Photosensitizer in Epidermal Keratinocytes.

Park SL, Justiniano R, Williams JD, Cabello CM, Qiao S, Wondrak GT.

J Invest Dermatol. 2015 Jun;135(6):1649-1658. doi: 10.1038/jid.2014.503. Epub 2014 Nov 28.


Phenotypic identification of the redox dye methylene blue as an antagonist of heat shock response gene expression in metastatic melanoma cells.

Davis AL, Cabello CM, Qiao S, Azimian S, Wondrak GT.

Int J Mol Sci. 2013 Feb 19;14(2):4185-202. doi: 10.3390/ijms14024185.


D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis.

Qiao S, Cabello CM, Lamore SD, Lesson JL, Wondrak GT.

Apoptosis. 2012 Oct;17(10):1079-94. doi: 10.1007/s10495-012-0746-x.


Thiostrepton is an inducer of oxidative and proteotoxic stress that impairs viability of human melanoma cells but not primary melanocytes.

Qiao S, Lamore SD, Cabello CM, Lesson JL, Muñoz-Rodriguez JL, Wondrak GT.

Biochem Pharmacol. 2012 May 1;83(9):1229-40. doi: 10.1016/j.bcp.2012.01.027. Epub 2012 Feb 1.


The redox antimalarial dihydroartemisinin targets human metastatic melanoma cells but not primary melanocytes with induction of NOXA-dependent apoptosis.

Cabello CM, Lamore SD, Bair WB 3rd, Qiao S, Azimian S, Lesson JL, Wondrak GT.

Invest New Drugs. 2012 Aug;30(4):1289-301. doi: 10.1007/s10637-011-9676-7. Epub 2011 May 6.


DCPIP (2,6-dichlorophenolindophenol) as a genotype-directed redox chemotherapeutic targeting NQO1*2 breast carcinoma.

Cabello CM, Lamore SD, Bair WB 3rd, Davis AL, Azimian SM, Wondrak GT.

Free Radic Res. 2011 Mar;45(3):276-92. doi: 10.3109/10715762.2010.526766. Epub 2010 Nov 1.


The malondialdehyde-derived fluorophore DHP-lysine is a potent sensitizer of UVA-induced photooxidative stress in human skin cells.

Lamore SD, Azimian S, Horn D, Anglin BL, Uchida K, Cabello CM, Wondrak GT.

J Photochem Photobiol B. 2010 Dec 2;101(3):251-64. doi: 10.1016/j.jphotobiol.2010.07.010. Epub 2010 Jul 30.


HMGB1-directed drug discovery targeting cutaneous inflammatory dysregulation.

Lamore SD, Cabello CM, Wondrak GT.

Curr Drug Metab. 2010 Mar;11(3):250-65. Review.


GLO1 overexpression in human malignant melanoma.

Bair WB 3rd, Cabello CM, Uchida K, Bause AS, Wondrak GT.

Melanoma Res. 2010 Apr;20(2):85-96. doi: 10.1097/CMR.0b013e3283364903.


The topical antimicrobial zinc pyrithione is a heat shock response inducer that causes DNA damage and PARP-dependent energy crisis in human skin cells.

Lamore SD, Cabello CM, Wondrak GT.

Cell Stress Chaperones. 2010 May;15(3):309-22. doi: 10.1007/s12192-009-0145-6. Epub 2009 Oct 7.


Antimelanoma activity of the redox dye DCPIP (2,6-dichlorophenolindophenol) is antagonized by NQO1.

Cabello CM, Bair WB 3rd, Bause AS, Wondrak GT.

Biochem Pharmacol. 2009 Aug 15;78(4):344-54. doi: 10.1016/j.bcp.2009.04.016. Epub 2009 Apr 24.


The experimental chemotherapeutic N6-furfuryladenosine (kinetin-riboside) induces rapid ATP depletion, genotoxic stress, and CDKN1A(p21) upregulation in human cancer cell lines.

Cabello CM, Bair WB 3rd, Ley S, Lamore SD, Azimian S, Wondrak GT.

Biochem Pharmacol. 2009 Apr 1;77(7):1125-38. doi: 10.1016/j.bcp.2008.12.002. Epub 2008 Dec 24.


The cinnamon-derived Michael acceptor cinnamic aldehyde impairs melanoma cell proliferation, invasiveness, and tumor growth.

Cabello CM, Bair WB 3rd, Lamore SD, Ley S, Bause AS, Azimian S, Wondrak GT.

Free Radic Biol Med. 2009 Jan 15;46(2):220-31. doi: 10.1016/j.freeradbiomed.2008.10.025. Epub 2008 Nov 1.


Cinnamoyl-based Nrf2-activators targeting human skin cell photo-oxidative stress.

Wondrak GT, Cabello CM, Villeneuve NF, Zhang S, Ley S, Li Y, Sun Z, Zhang DD.

Free Radic Biol Med. 2008 Aug 15;45(4):385-95. doi: 10.1016/j.freeradbiomed.2008.04.023. Epub 2008 Apr 26.


Experimental therapeutics: targeting the redox Achilles heel of cancer.

Cabello CM, Bair WB 3rd, Wondrak GT.

Curr Opin Investig Drugs. 2007 Dec;8(12):1022-37. Review.


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