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Nutrients. 2018 Jun 20;10(6). pii: E793. doi: 10.3390/nu10060793.

Inulin Supplementation Does Not Reduce Plasma Trimethylamine N-Oxide Concentrations in Individuals at Risk for Type 2 Diabetes.

Baugh ME1,2, Steele CN3,4, Angiletta CJ5,6, Mitchell CM7,8, Neilson AP9,10,11, Davy BM12,13, Hulver MW14,15,16, Davy KP17,18,19.

Author information

1
Department of Human Nutrition, Foods, and Exercise, 295 West Campus Dr., Virginia Tech, Blacksburg, VA 24061, USA. mebaugh@vt.edu.
2
Translational Obesity Research Graduate Education Program, Virginia Tech, Blacksburg, VA 24061, USA. mebaugh@vt.edu.
3
Department of Human Nutrition, Foods, and Exercise, 295 West Campus Dr., Virginia Tech, Blacksburg, VA 24061, USA. cnsteele@vt.edu.
4
Translational Obesity Research Graduate Education Program, Virginia Tech, Blacksburg, VA 24061, USA. cnsteele@vt.edu.
5
Department of Human Nutrition, Foods, and Exercise, 295 West Campus Dr., Virginia Tech, Blacksburg, VA 24061, USA. chrisa88@vt.edu.
6
Translational Obesity Research Graduate Education Program, Virginia Tech, Blacksburg, VA 24061, USA. chrisa88@vt.edu.
7
Department of Human Nutrition, Foods, and Exercise, 295 West Campus Dr., Virginia Tech, Blacksburg, VA 24061, USA. casmitch@vt.edu.
8
Translational Obesity Research Graduate Education Program, Virginia Tech, Blacksburg, VA 24061, USA. casmitch@vt.edu.
9
Translational Obesity Research Graduate Education Program, Virginia Tech, Blacksburg, VA 24061, USA. andrewn@vt.edu.
10
Department of Food Science and Technology, Integrated Life Sciences Building, 1981 Kraft Dr., Blacksburg, VA 24060, USA. andrewn@vt.edu.
11
The Metabolic Phenotyping Core, 1981 Kraft Dr., Virginia Tech, Blacksburg, VA 24061, USA. andrewn@vt.edu.
12
Department of Human Nutrition, Foods, and Exercise, 295 West Campus Dr., Virginia Tech, Blacksburg, VA 24061, USA. bdavy@vt.edu.
13
Translational Obesity Research Graduate Education Program, Virginia Tech, Blacksburg, VA 24061, USA. bdavy@vt.edu.
14
Department of Human Nutrition, Foods, and Exercise, 295 West Campus Dr., Virginia Tech, Blacksburg, VA 24061, USA. hulvermw@vt.edu.
15
Translational Obesity Research Graduate Education Program, Virginia Tech, Blacksburg, VA 24061, USA. hulvermw@vt.edu.
16
The Metabolic Phenotyping Core, 1981 Kraft Dr., Virginia Tech, Blacksburg, VA 24061, USA. hulvermw@vt.edu.
17
Department of Human Nutrition, Foods, and Exercise, 295 West Campus Dr., Virginia Tech, Blacksburg, VA 24061, USA. kdavy@vt.edu.
18
Translational Obesity Research Graduate Education Program, Virginia Tech, Blacksburg, VA 24061, USA. kdavy@vt.edu.
19
The Metabolic Phenotyping Core, 1981 Kraft Dr., Virginia Tech, Blacksburg, VA 24061, USA. kdavy@vt.edu.

Abstract

Trimethylamine N-oxide (TMAO) is associated with type 2 diabetes (T2DM) and increased risk of adverse cardiovascular events. Prebiotic supplementation has been purported to reduce TMAO production, but whether prebiotics reduce fasting or postprandial TMAO levels is unclear. Sedentary, overweight/obese adults at risk for T2DM (n = 18) were randomized to consume a standardized diet (55% carbohydrate, 30% fat) with 10 g/day of either an inulin supplement or maltodextrin placebo for 6 weeks. Blood samples were obtained in the fasting state and hourly during a 4-h high-fat challenge meal (820 kcal; 25% carbohydrate, 63% fat; 317.4 mg choline, 62.5 mg betaine, 8.1 mg l-carnitine) before and after the diet. Plasma TMAO and trimethylamine (TMA) moieties (choline, l-carnitine, betaine, and γ-butyrobetaine) were measured using isocratic ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). There were no differences in fasting or postprandial TMAO or TMA moieties between the inulin and placebo groups at baseline (all p > 0.05). There were no significant changes in fasting or postprandial plasma TMAO or TMA moiety concentrations following inulin or placebo. These findings suggest that inulin supplementation for 6 weeks did not reduce fasting or postprandial TMAO in individuals at risk for T2DM. Future studies are needed to identify efficacious interventions that reduce plasma TMAO concentrations.

KEYWORDS:

cardiovascular; metabolism; metabolite; prebiotic; prediabetes

PMID:
29925775
PMCID:
PMC6024751
DOI:
10.3390/nu10060793
[Indexed for MEDLINE]
Free PMC Article

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