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Items: 1 to 20 of 50

1.

Antiallodynic effects of the selective NaV1.7 inhibitor Pn3a in a mouse model of acute postsurgical pain: evidence for analgesic synergy with opioids and baclofen.

Mueller A, Starobova H, Morgan M, Dekan Z, Cheneval O, Schroeder CI, Alewood PF, Deuis JR, Vetter I.

Pain. 2019 Aug;160(8):1766-1780. doi: 10.1097/j.pain.0000000000001567.

PMID:
31335646
2.

Cyclizing Disulfide-Rich Peptides Using Sortase A.

Agwa AJ, Craik DJ, Schroeder CI.

Methods Mol Biol. 2019;2012:29-41. doi: 10.1007/978-1-4939-9546-2_3.

PMID:
31161502
3.

Anti-allodynic effects of the selective NaV1.7 inhibitor Pn3a in a mouse model of acute post-surgical pain: evidence for analgesic synergy with opioids and baclofen.

Mueller A, Starobova H, Morgan M, Dekan Z, Cheneval O, Schroeder CI, Alewood PF, Deuis JR, Vetter I.

Pain. 2019 Mar 21. doi: 10.1097/j.pain.0000000000001567. [Epub ahead of print]

PMID:
30908355
4.

Peptide-Membrane Interactions Affect the Inhibitory Potency and Selectivity of Spider Toxins ProTx-II and GpTx-1.

Lawrence N, Wu B, Ligutti J, Cheneval O, Agwa AJ, Benfield AH, Biswas K, Craik DJ, Miranda LP, Henriques ST, Schroeder CI.

ACS Chem Biol. 2019 Jan 18;14(1):118-130. doi: 10.1021/acschembio.8b00989. Epub 2018 Dec 21.

PMID:
30507158
5.

Where cone snails and spiders meet: design of small cyclic sodium-channel inhibitors.

Peigneur S, Cheneval O, Maiti M, Leipold E, Heinemann SH, Lescrinier E, Herdewijn P, De Lima ME, Craik DJ, Schroeder CI, Tytgat J.

FASEB J. 2019 Mar;33(3):3693-3703. doi: 10.1096/fj.201801909R. Epub 2018 Dec 3.

PMID:
30509130
6.

Targeted Delivery of Cyclotides via Conjugation to a Nanobody.

Kwon S, Duarte JN, Li Z, Ling JJ, Cheneval O, Durek T, Schroeder CI, Craik DJ, Ploegh HL.

ACS Chem Biol. 2018 Oct 19;13(10):2973-2980. doi: 10.1021/acschembio.8b00653. Epub 2018 Oct 5.

PMID:
30248263
7.

Efficient Enzymatic Ligation of Inhibitor Cystine Knot Spider Venom Peptides: Using Sortase A To Form Double-Knottins That Probe Voltage-Gated Sodium Channel NaV1.7.

Agwa AJ, Blomster LV, Craik DJ, King GF, Schroeder CI.

Bioconjug Chem. 2018 Oct 17;29(10):3309-3319. doi: 10.1021/acs.bioconjchem.8b00505. Epub 2018 Sep 12.

PMID:
30148615
8.

Engineering potent mesotrypsin inhibitors based on the plant-derived cyclic peptide, sunflower trypsin inhibitor-1.

de Veer SJ, Li CY, Swedberg JE, Schroeder CI, Craik DJ.

Eur J Med Chem. 2018 Jul 15;155:695-704. doi: 10.1016/j.ejmech.2018.06.029. Epub 2018 Jun 21.

PMID:
29936356
9.

Calcium-Mediated Allostery of the EGF Fold.

Wang CK, Ghani HA, Bundock A, Weidmann J, Harvey PJ, Edwards IA, Schroeder CI, Swedberg JE, Craik DJ.

ACS Chem Biol. 2018 Jun 15;13(6):1659-1667. doi: 10.1021/acschembio.8b00291. Epub 2018 May 9.

PMID:
29715432
10.

Gating modifier toxins isolated from spider venom: Modulation of voltage-gated sodium channels and the role of lipid membranes.

Agwa AJ, Peigneur S, Chow CY, Lawrence N, Craik DJ, Tytgat J, King GF, Henriques ST, Schroeder CI.

J Biol Chem. 2018 Jun 8;293(23):9041-9052. doi: 10.1074/jbc.RA118.002553. Epub 2018 Apr 27.

11.

Bioactive Compounds Isolated from Neglected Predatory Marine Gastropods.

Turner AH, Craik DJ, Kaas Q, Schroeder CI.

Mar Drugs. 2018 Apr 5;16(4). pii: E118. doi: 10.3390/md16040118. Review.

12.

Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1.

Durek T, Cromm PM, White AM, Schroeder CI, Kaas Q, Weidmann J, Ahmad Fuaad A, Cheneval O, Harvey PJ, Daly NL, Zhou Y, Dellsén A, Österlund T, Larsson N, Knerr L, Bauer U, Kessler H, Cai M, Hruby VJ, Plowright AT, Craik DJ.

J Med Chem. 2018 Apr 26;61(8):3674-3684. doi: 10.1021/acs.jmedchem.8b00170. Epub 2018 Apr 11.

13.

Corrigendum to "Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNaV1.7" [Biochim. Biophys. Acta 1859(5) (2017) 835-844].

Agwa AJ, Lawrence N, Deplazes E, Cheneval O, Chen RM, Craik DJ, Schroeder CI, Henriques ST.

Biochim Biophys Acta Biomembr. 2017 Nov;1859(11):2277. doi: 10.1016/j.bbamem.2017.08.008. Epub 2017 Aug 25. No abstract available.

14.

Lengths of the C-Terminus and Interconnecting Loops Impact Stability of Spider-Derived Gating Modifier Toxins.

Agwa AJ, Huang YH, Craik DJ, Henriques ST, Schroeder CI.

Toxins (Basel). 2017 Aug 12;9(8). pii: E248. doi: 10.3390/toxins9080248.

15.

Modelling the interactions between animal venom peptides and membrane proteins.

Hung A, Kuyucak S, Schroeder CI, Kaas Q.

Neuropharmacology. 2017 Dec;127:20-31. doi: 10.1016/j.neuropharm.2017.07.036. Epub 2017 Aug 2. Review.

PMID:
28778835
16.

Gating modifier toxin interactions with ion channels and lipid bilayers: Is the trimolecular complex real?

Agwa AJ, Henriques ST, Schroeder CI.

Neuropharmacology. 2017 Dec;127:32-45. doi: 10.1016/j.neuropharm.2017.04.004. Epub 2017 Apr 8. Review.

PMID:
28400258
17.

Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNaV1.7.

Agwa AJ, Lawrence N, Deplazes E, Cheneval O, Chen RM, Craik DJ, Schroeder CI, Henriques ST.

Biochim Biophys Acta Biomembr. 2017 May;1859(5):835-844. doi: 10.1016/j.bbamem.2017.01.020. Epub 2017 Jan 20. Erratum in: Biochim Biophys Acta. 2017 Nov;1859(11):2277.

18.

Structural and functional characterization of chimeric cyclotides from the Möbius and trypsin inhibitor subfamilies.

Abdul Ghani H, Henriques ST, Huang YH, Swedberg JE, Schroeder CI, Craik DJ.

Biopolymers. 2017 Jan;108(1). doi: 10.1002/bip.22927.

PMID:
27487329
19.

Substrate-Guided Design of Selective FXIIa Inhibitors Based on the Plant-Derived Momordica cochinchinensis Trypsin Inhibitor-II (MCoTI-II) Scaffold.

Swedberg JE, Mahatmanto T, Abdul Ghani H, de Veer SJ, Schroeder CI, Harris JM, Craik DJ.

J Med Chem. 2016 Aug 11;59(15):7287-92. doi: 10.1021/acs.jmedchem.6b00557. Epub 2016 Aug 1.

PMID:
27434175
20.

Interaction of Tarantula Venom Peptide ProTx-II with Lipid Membranes Is a Prerequisite for Its Inhibition of Human Voltage-gated Sodium Channel NaV1.7.

Henriques ST, Deplazes E, Lawrence N, Cheneval O, Chaousis S, Inserra M, Thongyoo P, King GF, Mark AE, Vetter I, Craik DJ, Schroeder CI.

J Biol Chem. 2016 Aug 12;291(33):17049-65. doi: 10.1074/jbc.M116.729095. Epub 2016 Jun 16.

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