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Items: 1 to 20 of 37


Lengths of the C-Terminus and Interconnecting Loops Impact Stability of Spider-Derived Gating Modifier Toxins.

Agwa AJ, Huang YH, Craik DJ, Henriques ST, Schroeder CI.

Toxins (Basel). 2017 Aug 12;9(8). pii: E248. doi: 10.3390/toxins9080248.


Modelling the interactions between animal venom peptides and membrane proteins.

Hung A, Kuyucak S, Schroeder CI, Kaas Q.

Neuropharmacology. 2017 Aug 1. pii: S0028-3908(17)30367-2. doi: 10.1016/j.neuropharm.2017.07.036. [Epub ahead of print] Review.


Gating modifier toxin interactions with ion channels and lipid bilayers: Is the trimolecular complex real?

Agwa AJ, Henriques ST, Schroeder CI.

Neuropharmacology. 2017 Apr 8. pii: S0028-3908(17)30141-7. doi: 10.1016/j.neuropharm.2017.04.004. [Epub ahead of print] Review.


Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNaV1.7.

Agwa AJ, Lawrence N, Deplazes E, Cheneval O, Chen RM, Craik DJ, Schroeder CI, Henriques ST.

Biochim Biophys Acta. 2017 May;1859(5):835-844. doi: 10.1016/j.bbamem.2017.01.020. Epub 2017 Jan 20.


Structural and functional characterization of chimeric cyclotides from the Möbius and trypsin inhibitor subfamilies.

Abdul Ghani H, Henriques ST, Huang YH, Swedberg JE, Schroeder CI, Craik DJ.

Biopolymers. 2017 Jan;108(1). doi: 10.1002/bip.22927.


Substrate-Guided Design of Selective FXIIa Inhibitors Based on the Plant-Derived Momordica cochinchinensis Trypsin Inhibitor-II (MCoTI-II) Scaffold.

Swedberg JE, Mahatmanto T, Abdul Ghani H, de Veer SJ, Schroeder CI, Harris JM, Craik DJ.

J Med Chem. 2016 Aug 11;59(15):7287-92. doi: 10.1021/acs.jmedchem.6b00557. Epub 2016 Aug 1.


Interaction of Tarantula Venom Peptide ProTx-II with Lipid Membranes Is a Prerequisite for Its Inhibition of Human Voltage-gated Sodium Channel NaV1.7.

Henriques ST, Deplazes E, Lawrence N, Cheneval O, Chaousis S, Inserra M, Thongyoo P, King GF, Mark AE, Vetter I, Craik DJ, Schroeder CI.

J Biol Chem. 2016 Aug 12;291(33):17049-65. doi: 10.1074/jbc.M116.729095. Epub 2016 Jun 16.


Truncated Glucagon-like Peptide-1 and Exendin-4 α-Conotoxin pl14a Peptide Chimeras Maintain Potency and α-Helicity and Reveal Interactions Vital for cAMP Signaling in Vitro.

Swedberg JE, Schroeder CI, Mitchell JM, Fairlie DP, Edmonds DJ, Griffith DA, Ruggeri RB, Derksen DR, Loria PM, Price DA, Liras S, Craik DJ.

J Biol Chem. 2016 Jul 22;291(30):15778-87. doi: 10.1074/jbc.M116.724542. Epub 2016 May 10.


Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide.

Kwon S, Bosmans F, Kaas Q, Cheneval O, Conibear AC, Rosengren KJ, Wang CK, Schroeder CI, Craik DJ.

Biotechnol Bioeng. 2016 Oct;113(10):2202-12. doi: 10.1002/bit.25993. Epub 2016 Aug 9.


Development of a μO-Conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Sodium Channel NaV1.8.

Deuis JR, Dekan Z, Inserra MC, Lee TH, Aguilar MI, Craik DJ, Lewis RJ, Alewood PF, Mobli M, Schroeder CI, Henriques ST, Vetter I.

J Biol Chem. 2016 May 27;291(22):11829-42. doi: 10.1074/jbc.M116.721662. Epub 2016 Mar 29.


Membrane-binding properties of gating modifier and pore-blocking toxins: Membrane interaction is not a prerequisite for modification of channel gating.

Deplazes E, Henriques ST, Smith JJ, King GF, Craik DJ, Mark AE, Schroeder CI.

Biochim Biophys Acta. 2016 Apr;1858(4):872-82. doi: 10.1016/j.bbamem.2016.02.002. Epub 2016 Feb 2.


Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization.

Conibear AC, Chaousis S, Durek T, Rosengren KJ, Craik DJ, Schroeder CI.

Biopolymers. 2016 Jan;106(1):89-100. doi: 10.1002/bip.22767.


Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonists.

Swedberg JE, Schroeder CI, Mitchell JM, Durek T, Fairlie DP, Edmonds DJ, Griffith DA, Ruggeri RB, Derksen DR, Loria PM, Liras S, Price DA, Craik DJ.

Eur J Med Chem. 2015 Oct 20;103:175-84. doi: 10.1016/j.ejmech.2015.08.046. Epub 2015 Aug 29.


Rational design and synthesis of an orally bioavailable peptide guided by NMR amide temperature coefficients.

Wang CK, Northfield SE, Colless B, Chaousis S, Hamernig I, Lohman RJ, Nielsen DS, Schroeder CI, Liras S, Price DA, Fairlie DP, Craik DJ.

Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17504-9.


Cyclic Penta- and Hexaleucine Peptides without N-Methylation Are Orally Absorbed.

Hill TA, Lohman RJ, Hoang HN, Nielsen DS, Scully CC, Kok WM, Liu L, Lucke AJ, Stoermer MJ, Schroeder CI, Chaousis S, Colless B, Bernhardt PV, Edmonds DJ, Griffith DA, Rotter CJ, Ruggeri RB, Price DA, Liras S, Craik DJ, Fairlie DP.

ACS Med Chem Lett. 2014 Aug 4;5(10):1148-51. doi: 10.1021/ml5002823. eCollection 2014 Oct 9.


Fmoc-based synthesis of disulfide-rich cyclic peptides.

Cheneval O, Schroeder CI, Durek T, Walsh P, Huang YH, Liras S, Price DA, Craik DJ.

J Org Chem. 2014 Jun 20;79(12):5538-44. doi: 10.1021/jo500699m. Epub 2014 Jun 11.


Disulfide-rich macrocyclic peptides as templates in drug design.

Northfield SE, Wang CK, Schroeder CI, Durek T, Kan MW, Swedberg JE, Craik DJ.

Eur J Med Chem. 2014 Apr 22;77:248-57. doi: 10.1016/j.ejmech.2014.03.011. Epub 2014 Mar 6. Review.


High-throughput synthesis of peptide α-thioesters: a safety catch linker approach enabling parallel hydrogen fluoride cleavage.

Brust A, Schroeder CI, Alewood PF.

ChemMedChem. 2014 May;9(5):1038-46. doi: 10.1002/cmdc.201300524. Epub 2014 Mar 3.


Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro.

Schroeder CI, Swedberg JE, Withka JM, Rosengren KJ, Akcan M, Clayton DJ, Daly NL, Cheneval O, Borzilleri KA, Griffor M, Stock I, Colless B, Walsh P, Sunderland P, Reyes A, Dullea R, Ammirati M, Liu S, McClure KF, Tu M, Bhattacharya SK, Liras S, Price DA, Craik DJ.

Chem Biol. 2014 Feb 20;21(2):284-94. doi: 10.1016/j.chembiol.2013.11.014. Epub 2014 Jan 16.


Semienzymatic cyclization of disulfide-rich peptides using Sortase A.

Jia X, Kwon S, Wang CI, Huang YH, Chan LY, Tan CC, Rosengren KJ, Mulvenna JP, Schroeder CI, Craik DJ.

J Biol Chem. 2014 Mar 7;289(10):6627-38. doi: 10.1074/jbc.M113.539262. Epub 2014 Jan 14.

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