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Items: 1 to 20 of 145

1.

Radical rearrangement and transfer reactions in proteins.

Schöneich C.

Essays Biochem. 2020 Jan 10. pii: EBC20190046. doi: 10.1042/EBC20190046. [Epub ahead of print]

PMID:
31922197
2.

Thiyl Radical Reactions in the Chemical Degradation of Pharmaceutical Proteins.

Schöneich C.

Molecules. 2019 Nov 28;24(23). pii: E4357. doi: 10.3390/molecules24234357. Review.

3.

Comparison of Polysorbate 80 Hydrolysis and Oxidation on the Aggregation of a Monoclonal Antibody.

Larson NR, Wei Y, Prajapati I, Chakraborty A, Peters B, Kalonia C, Hudak S, Choudhary S, Esfandiary R, Dhar P, Schöneich C, Middaugh CR.

J Pharm Sci. 2020 Jan;109(1):633-639. doi: 10.1016/j.xphs.2019.10.069. Epub 2019 Nov 20.

PMID:
31758949
4.

Cis/Trans Isomerization of Unsaturated Fatty Acids in Polysorbate 80 During Light Exposure of a Monoclonal Antibody-Containing Formulation.

Prajapati I, Peters BH, Larson NR, Wei Y, Choudhary S, Kalonia C, Hudak S, Esfandiary R, Middaugh CR, Schöneich C.

J Pharm Sci. 2020 Jan;109(1):603-613. doi: 10.1016/j.xphs.2019.10.068. Epub 2019 Nov 9.

PMID:
31715179
5.

Effects of Glycan Structure on the Stability and Receptor Binding of an IgG4-Fc.

Kang H, Larson NR, White DR, Middaugh CR, Tolbert T, Schöneich C.

J Pharm Sci. 2020 Jan;109(1):677-689. doi: 10.1016/j.xphs.2019.10.036. Epub 2019 Oct 25.

PMID:
31669606
6.

Proteolysis and Oxidation of Therapeutic Proteins After Intradermal or Subcutaneous Administration.

Varkhede N, Bommana R, Schöneich C, Forrest ML.

J Pharm Sci. 2020 Jan;109(1):191-205. doi: 10.1016/j.xphs.2019.08.005. Epub 2019 Aug 10. Review.

PMID:
31408633
7.

Effect of Iron Oxide Nanoparticles on the Oxidation and Secondary Structure of Growth Hormone.

Varkhede N, Peters BH, Wei Y, Middaugh CR, Schöneich C, Forrest ML.

J Pharm Sci. 2019 Oct;108(10):3372-3381. doi: 10.1016/j.xphs.2019.06.007. Epub 2019 Jun 16.

PMID:
31216451
8.

Xanthine oxidase-mediated oxidative stress promotes cancer cell-specific apoptosis.

Xu H, Li C, Mozziconacci O, Zhu R, Xu Y, Tang Y, Chen R, Huang Y, Holzbeierlein JM, Schöneich C, Huang J, Li B.

Free Radic Biol Med. 2019 Aug 1;139:70-79. doi: 10.1016/j.freeradbiomed.2019.05.019. Epub 2019 May 16.

PMID:
31103463
9.

Photoinduced Tyrosine Side Chain Fragmentation in IgG4-Fc: Mechanisms and Solvent Isotope Effects.

Kang H, Tolbert TJ, Schöneich C.

Mol Pharm. 2019 Jan 7;16(1):258-272. doi: 10.1021/acs.molpharmaceut.8b00979. Epub 2018 Dec 24.

PMID:
30540909
10.

Glatiramer acetate persists at the injection site and draining lymph nodes via electrostatically-induced aggregation.

Song JY, Larson NR, Thati S, Torres-Vazquez I, Martinez-Rivera N, Subelzu NJ, Leon MA, Rosa-Molinar E, Schöneich C, Forrest ML, Middaugh CR, Berkland CJ.

J Control Release. 2019 Jan 10;293:36-47. doi: 10.1016/j.jconrel.2018.11.007. Epub 2018 Nov 7.

11.

Silicone Oil-Free Polymer Syringes for the Storage of Therapeutic Proteins.

Werner BP, Schöneich C, Winter G.

J Pharm Sci. 2019 Mar;108(3):1148-1160. doi: 10.1016/j.xphs.2018.10.049. Epub 2018 Nov 2.

PMID:
30391415
12.

Identification of D-Amino Acids in Light Exposed mAb Formulations.

Bommana R, Subelzu N, Mozziconacci O, Sreedhara A, Schöneich C.

Pharm Res. 2018 Oct 17;35(11):238. doi: 10.1007/s11095-018-2520-4.

PMID:
30334107
13.

Fragmentation of a Monoclonal Antibody by Peroxotungstate.

Rathnayaka H, Mozziconacci O, Sreedhara A, Schöneich C.

Pharm Res. 2018 Sep 25;35(11):219. doi: 10.1007/s11095-018-2496-0.

PMID:
30255209
14.

Investigation of Metal-Catalyzed Antibody Carbonylation With an Improved Protein Carbonylation Assay.

Yang Y, Mah A, Yuk IH, Grewal PS, Pynn A, Cole W, Gao D, Zhang F, Chen J, Gennaro L, Schöneich C.

J Pharm Sci. 2018 Oct;107(10):2570-2580. doi: 10.1016/j.xphs.2018.06.015. Epub 2018 Jun 21.

PMID:
29935298
15.

Postproduction Handling and Administration of Protein Pharmaceuticals and Potential Instability Issues.

Nejadnik MR, Randolph TW, Volkin DB, Schöneich C, Carpenter JF, Crommelin DJA, Jiskoot W.

J Pharm Sci. 2018 Aug;107(8):2013-2019. doi: 10.1016/j.xphs.2018.04.005. Epub 2018 Apr 14.

PMID:
29665382
16.

Light-Induced Covalent Buffer Adducts to Histidine in a Model Protein.

Lei M, Quan C, Wang YJ, Kao YH, Schöneich C.

Pharm Res. 2018 Feb 20;35(3):67. doi: 10.1007/s11095-017-2339-4.

PMID:
29464419
17.

Understanding the Increased Aggregation Propensity of a Light-Exposed IgG1 Monoclonal Antibody Using Hydrogen Exchange Mass Spectrometry, Biophysical Characterization, and Structural Analysis.

Bommana R, Chai Q, Schöneich C, Weiss WF 4th, Majumdar R.

J Pharm Sci. 2018 Jun;107(6):1498-1511. doi: 10.1016/j.xphs.2018.01.017. Epub 2018 Jan 31.

PMID:
29408480
18.

Photodegradation Pathways of Protein Disulfides: Human Growth Hormone.

Steinmann D, Mozziconacci O, Bommana R, Stobaugh JF, Wang YJ, Schöneich C.

Pharm Res. 2017 Dec;34(12):2756-2778. doi: 10.1007/s11095-017-2256-6. Epub 2017 Sep 18.

PMID:
28924868
19.

Profiling the Photochemical-Induced Degradation of Rat Growth Hormone with Extreme Ultra-pressure Chromatography-Mass Spectrometry Utilizing Meter-Long Microcapillary Columns Packed with Sub-2-μm Particles.

Mozziconacci O, Stobaugh JT, Bommana R, Woods J, Franklin E, Jorgenson JW, Forrest ML, Schöneich C, Stobaugh JF.

Chromatographia. 2017 Sep;80(9):1299-1318. doi: 10.1007/s10337-017-3344-9. Epub 2017 Jul 4.

20.

Comparative Characterization of Crofelemer Samples Using Data Mining and Machine Learning Approaches With Analytical Stability Data Sets.

Nariya MK, Kim JH, Xiong J, Kleindl PA, Hewarathna A, Fisher AC, Joshi SB, Schöneich C, Forrest ML, Middaugh CR, Volkin DB, Deeds EJ.

J Pharm Sci. 2017 Nov;106(11):3270-3279. doi: 10.1016/j.xphs.2017.07.013. Epub 2017 Jul 22.

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