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Items: 1 to 20 of 26


Translational Imaging Spectroscopy for Proximal Sensing.

Rogass C, Koerting FM, Mielke C, Brell M, Boesche NK, Bade M, Hohmann C.

Sensors (Basel). 2017 Aug 11;17(8). pii: E1857. doi: 10.3390/s17081857.


Human RAD52 - a novel player in DNA repair in cancer and immunodeficiency.

Ghosh S, Hönscheid A, Dückers G, Ginzel S, Gohlke H, Gombert M, Kempkes B, Klapper W, Kuhlen M, Laws HJ, Linka RM, Meisel R, Mielke C, Niehues T, Schindler D, Schneider D, Schuster FR, Speckmann C, Borkhardt A.

Haematologica. 2017 Feb;102(2):e69-e72. doi: 10.3324/haematol.2016.155838. Epub 2016 Dec 15. No abstract available.


Spatio-temporal regulation of the human licensing factor Cdc6 in replication and mitosis.

Kalfalah FM, Berg E, Christensen MO, Linka RM, Dirks WG, Boege F, Mielke C.

Cell Cycle. 2015;14(11):1704-15. doi: 10.1080/15384101.2014.1000182.


Localization of MLH3 at the centrosomes.

Roesner LM, Mielke C, Faehnrich S, Merkhoffer Y, Dittmar KE, Drexler HG, Dirks WG.

Int J Mol Sci. 2014 Aug 11;15(8):13932-7. doi: 10.3390/ijms150813932.


Negative regulation of mitochondrial transcription by mitochondrial topoisomerase I.

Sobek S, Dalla Rosa I, Pommier Y, Bornholz B, Kalfalah F, Zhang H, Wiesner RJ, von Kleist-Retzow JC, Hillebrand F, Schaal H, Mielke C, Christensen MO, Boege F.

Nucleic Acids Res. 2013 Nov;41(21):9848-57. doi: 10.1093/nar/gkt768. Epub 2013 Aug 27.


Stable expression of MutLγ in human cells reveals no specific response to mismatched DNA, but distinct recruitment to damage sites.

Roesner LM, Mielke C, Fähnrich S, Merkhoffer Y, Dittmar KE, Drexler HG, Dirks WG.

J Cell Biochem. 2013 Oct;114(10):2405-14. doi: 10.1002/jcb.24591.


Impact of human autoantibodies on β1-adrenergic receptor conformation, activity, and internalization.

Bornholz B, Weidtkamp-Peters S, Schmitmeier S, Seidel CA, Herda LR, Felix SB, Lemoine H, Hescheler J, Nguemo F, Schäfer C, Christensen MO, Mielke C, Boege F.

Cardiovasc Res. 2013 Mar 1;97(3):472-80. doi: 10.1093/cvr/cvs350. Epub 2012 Dec 3.


Target genes of Topoisomerase IIβ regulate neuronal survival and are defined by their chromatin state.

Tiwari VK, Burger L, Nikoletopoulou V, Deogracias R, Thakurela S, Wirbelauer C, Kaut J, Terranova R, Hoerner L, Mielke C, Boege F, Murr R, Peters AH, Barde YA, Schübeler D.

Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):E934-43. doi: 10.1073/pnas.1119798109. Epub 2012 Apr 2.


XRCC4 controls nuclear import and distribution of Ligase IV and exchanges faster at damaged DNA in complex with Ligase IV.

Berg E, Christensen MO, Dalla Rosa I, Wannagat E, Jänicke RU, Rösner LM, Dirks WG, Boege F, Mielke C.

DNA Repair (Amst). 2011 Dec 10;10(12):1232-42. doi: 10.1016/j.dnarep.2011.09.012. Epub 2011 Oct 5.


53BP1 and MDC1 foci formation in HT-1080 cells for low- and high-LET microbeam irradiations.

Mosconi M, Giesen U, Langner F, Mielke C, Dalla Rosa I, Dirks WG.

Radiat Environ Biophys. 2011 Aug;50(3):345-52. doi: 10.1007/s00411-011-0366-9. Epub 2011 May 11.


Genotoxicity of dietary, environmental and therapeutic topoisomerase II poisons is uniformly correlated to prolongation of enzyme DNA residence.

Kalfalah FM, Mielke C, Christensen MO, Baechler S, Marko D, Boege F.

Mol Nutr Food Res. 2011 May;55 Suppl 1:S127-42. doi: 10.1002/mnfr.201000509. Epub 2011 Mar 24.


Repair of DNA damage induced by the mycotoxin alternariol involves tyrosyl-DNA phosphodiesterase 1.

Fehr M, Baechler S, Kropat C, Mielke C, Boege F, Pahlke G, Marko D.

Mycotoxin Res. 2010 Nov;26(4):247-56. doi: 10.1007/s12550-010-0063-6. Epub 2010 Jul 27.


Mitotic chromosomes are constrained by topoisomerase II-sensitive DNA entanglements.

Kawamura R, Pope LH, Christensen MO, Sun M, Terekhova K, Boege F, Mielke C, Andersen AH, Marko JF.

J Cell Biol. 2010 Mar 8;188(5):653-63. doi: 10.1083/jcb.200910085. Epub 2010 Mar 1.


Adaptation of topoisomerase I paralogs to nuclear and mitochondrial DNA.

Dalla Rosa I, Goffart S, Wurm M, Wiek C, Essmann F, Sobek S, Schroeder P, Zhang H, Krutmann J, Hanenberg H, Schulze-Osthoff K, Mielke C, Pommier Y, Boege F, Christensen MO.

Nucleic Acids Res. 2009 Oct;37(19):6414-28. doi: 10.1093/nar/gkp708. Epub 2009 Aug 31.


Rapid and prolonged stalling of human DNA topoisomerase I in UVA-irradiated genomic areas.

Mielke C, Kalfalah FM, Christensen MO, Boege F.

DNA Repair (Amst). 2007 Dec 1;6(12):1757-63. Epub 2007 Aug 31.


C-terminal regions of topoisomerase IIalpha and IIbeta determine isoform-specific functioning of the enzymes in vivo.

Linka RM, Porter AC, Volkov A, Mielke C, Boege F, Christensen MO.

Nucleic Acids Res. 2007;35(11):3810-22. Epub 2007 May 25.


TDP1 overexpression in human cells counteracts DNA damage mediated by topoisomerases I and II.

Barthelmes HU, Habermeyer M, Christensen MO, Mielke C, Interthal H, Pouliot JJ, Boege F, Marko D.

J Biol Chem. 2004 Dec 31;279(53):55618-25. Epub 2004 Oct 19.


Inferring a system model of subcellular topoisomerase II beta localization dynamics.

Athale CA, Christensen MO, Eils R, Boege F, Mielke C.

OMICS. 2004 Summer;8(2):167-75.


Enhanced processing of UVA-irradiated DNA by human topoisomerase II in living cells.

Mielke C, Christensen MO, Barthelmes HU, Boege F.

J Biol Chem. 2004 May 14;279(20):20559-62. Epub 2004 Mar 23.


Distinct effects of topoisomerase I and RNA polymerase I inhibitors suggest a dual mechanism of nucleolar/nucleoplasmic partitioning of topoisomerase I.

Christensen MO, Krokowski RM, Barthelmes HU, Hock R, Boege F, Mielke C.

J Biol Chem. 2004 May 21;279(21):21873-82. Epub 2004 Mar 9.

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