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J Magn Reson. 2018 May;290:68-75. doi: 10.1016/j.jmr.2018.03.010. Epub 2018 Mar 17.

R1 dispersion contrast at high field with fast field-cycling MRI.

Author information

1
Institute of Medical Engineering, Graz University of Technology, Stremayrgasse 16, A-8010 Graz, Austria. Electronic address: m.boedenler@tugraz.at.
2
Physic Deppartment and INSTM, Università degli Studi di Milano, Via Celoria 16, I-20133 Milan, Italy.
3
Department of Chemical and Soil Sciences and INSTM, University of Cagliari, I-09042 Monserrato, CA, Italy.
4
Faculty of Mathematics and Computer Science, University of Warmia and Mazury, Słoneczna 54, 10-710 Olsztyn, Poland.
5
Institute of Medical Engineering, Graz University of Technology, Stremayrgasse 16, A-8010 Graz, Austria.

Abstract

Contrast agents with a strong R1 dispersion have been shown to be effective in generating target-specific contrast in MRI. The utilization of this R1 field dependence requires the adaptation of an MRI scanner for fast field-cycling (FFC). Here, we present the first implementation and validation of FFC-MRI at a clinical field strength of 3 T. A field-cycling range of ±100 mT around the nominal B0 field was realized by inserting an additional insert coil into an otherwise conventional MRI system. System validation was successfully performed with selected iron oxide magnetic nanoparticles and comparison to FFC-NMR relaxometry measurements. Furthermore, we show proof-of-principle R1 dispersion imaging and demonstrate the capability of generating R1 dispersion contrast at high field with suppressed background signal. With the presented ready-to-use hardware setup it is possible to investigate MRI contrast agents with a strong R1 dispersion at a field strength of 3 T.

KEYWORDS:

Contrast agent; Delta relaxation enhanced MR; Dispersion; Fast field-cycling; MRI; Quadrupole relaxation enhancement

PMID:
29574318
DOI:
10.1016/j.jmr.2018.03.010
[Indexed for MEDLINE]

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