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Items: 1 to 20 of 50

1.

Broad-spectrum agents for flaviviral infections: dengue, Zika and beyond.

Boldescu V, Behnam MAM, Vasilakis N, Klein CD.

Nat Rev Drug Discov. 2017 Aug;16(8):565-586. doi: 10.1038/nrd.2017.33. Epub 2017 May 5. Review.

2.

Solution conformations of a linked construct of the Zika virus NS2B-NS3 protease.

Mahawaththa MC, Pearce BJG, Szabo M, Graham B, Klein CD, Nitsche C, Otting G.

Antiviral Res. 2017 Jun;142:141-147. doi: 10.1016/j.antiviral.2017.03.011. Epub 2017 Mar 21.

PMID:
28336347
3.

Peptide-Boronic Acid Inhibitors of Flaviviral Proteases: Medicinal Chemistry and Structural Biology.

Nitsche C, Zhang L, Weigel LF, Schilz J, Graf D, Bartenschlager R, Hilgenfeld R, Klein CD.

J Med Chem. 2017 Jan 12;60(1):511-516. doi: 10.1021/acs.jmedchem.6b01021. Epub 2016 Dec 14.

PMID:
27966962
4.

Identification of fused bicyclic derivatives of pyrrolidine and imidazolidinone as dengue virus-2 NS2B-NS3 protease inhibitors.

Weng Z, Shao X, Graf D, Wang C, Klein CD, Wang J, Zhou GC.

Eur J Med Chem. 2017 Jan 5;125:751-759. doi: 10.1016/j.ejmech.2016.09.063. Epub 2016 Sep 21.

PMID:
27721158
5.

Discovery of novel Tetrahydrobenzo[b]thiophene and pyrrole based scaffolds as potent and selective CB2 receptor ligands: The structural elements controlling binding affinity, selectivity and functionality.

Osman NA, Ligresti A, Klein CD, Allarà M, Rabbito A, Di Marzo V, Abouzid KA, Abadi AH.

Eur J Med Chem. 2016 Oct 21;122:619-634. doi: 10.1016/j.ejmech.2016.07.012. Epub 2016 Jul 9.

PMID:
27448919
6.

Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor.

Lei J, Hansen G, Nitsche C, Klein CD, Zhang L, Hilgenfeld R.

Science. 2016 Jul 29;353(6298):503-5. doi: 10.1126/science.aag2419. Epub 2016 Jul 7.

7.

Solid Phase Synthesis of C-Terminal Boronic Acid Peptides.

Behnam MA, Sundermann TR, Klein CD.

Org Lett. 2016 May 6;18(9):2016-9. doi: 10.1021/acs.orglett.6b00625. Epub 2016 Apr 22.

PMID:
27104613
8.

N-Terminal methionine processing by the zinc-activated Plasmodium falciparum methionine aminopeptidase 1b.

Calcagno S, Klein CD.

Appl Microbiol Biotechnol. 2016 Aug;100(16):7091-102. doi: 10.1007/s00253-016-7470-3. Epub 2016 Mar 29.

PMID:
27023914
9.

Sensitive NMR Approach for Determining the Binding Mode of Tightly Binding Ligand Molecules to Protein Targets.

Chen WN, Nitsche C, Pilla KB, Graham B, Huber T, Klein CD, Otting G.

J Am Chem Soc. 2016 Apr 6;138(13):4539-46. doi: 10.1021/jacs.6b00416. Epub 2016 Mar 24.

PMID:
26974502
10.

The Medicinal Chemistry of Dengue Virus.

Behnam MA, Nitsche C, Boldescu V, Klein CD.

J Med Chem. 2016 Jun 23;59(12):5622-49. doi: 10.1021/acs.jmedchem.5b01653. Epub 2016 Feb 5. Review.

PMID:
26771861
11.

Spiroepoxytriazoles Are Fumagillin-like Irreversible Inhibitors of MetAP2 with Potent Cellular Activity.

Morgen M, Jöst C, Malz M, Janowski R, Niessing D, Klein CD, Gunkel N, Miller AK.

ACS Chem Biol. 2016 Apr 15;11(4):1001-11. doi: 10.1021/acschembio.5b00755. Epub 2016 Jan 19.

PMID:
26686773
12.

Discovery of Nanomolar Dengue and West Nile Virus Protease Inhibitors Containing a 4-Benzyloxyphenylglycine Residue.

Behnam MA, Graf D, Bartenschlager R, Zlotos DP, Klein CD.

J Med Chem. 2015 Dec 10;58(23):9354-70. doi: 10.1021/acs.jmedchem.5b01441. Epub 2015 Dec 1.

PMID:
26562070
13.

Phenylalanine and Phenylglycine Analogues as Arginine Mimetics in Dengue Protease Inhibitors.

Weigel LF, Nitsche C, Graf D, Bartenschlager R, Klein CD.

J Med Chem. 2015 Oct 8;58(19):7719-33. doi: 10.1021/acs.jmedchem.5b00612. Epub 2015 Sep 30.

PMID:
26367391
14.

Dual inhibitors of the dengue and West Nile virus NS2B-NS3 proteases: Synthesis, biological evaluation and docking studies of novel peptide-hybrids.

Bastos Lima A, Behnam MA, El Sherif Y, Nitsche C, Vechi SM, Klein CD.

Bioorg Med Chem. 2015 Sep 1;23(17):5748-55. doi: 10.1016/j.bmc.2015.07.012. Epub 2015 Jul 15.

PMID:
26233795
15.

Metal promiscuity and metal-dependent substrate preferences of Trypanosoma brucei methionine aminopeptidase 1.

Marschner A, Klein CD.

Biochimie. 2015 Aug;115:35-43. doi: 10.1016/j.biochi.2015.04.012. Epub 2015 Apr 25.

PMID:
25921435
16.

Beta-aminoketones as prodrugs for selective irreversible inhibitors of type-1 methionine aminopeptidases.

Altmeyer M, Amtmann E, Heyl C, Marschner A, Scheidig AJ, Klein CD.

Bioorg Med Chem Lett. 2014 Nov 15;24(22):5310-4. doi: 10.1016/j.bmcl.2014.09.047. Epub 2014 Sep 23.

PMID:
25293447
17.

Biochemistry and medicinal chemistry of the dengue virus protease.

Nitsche C, Holloway S, Schirmeister T, Klein CD.

Chem Rev. 2014 Nov 26;114(22):11348-81. doi: 10.1021/cr500233q. Epub 2014 Sep 30. Review. No abstract available.

PMID:
25268322
18.

C-terminal residue optimization and fragment merging: discovery of a potent Peptide-hybrid inhibitor of dengue protease.

Behnam MA, Nitsche C, Vechi SM, Klein CD.

ACS Med Chem Lett. 2014 Jul 18;5(9):1037-42. doi: 10.1021/ml500245v. eCollection 2014 Sep 11.

19.

Promiscuity and selectivity in covalent enzyme inhibition: a systematic study of electrophilic fragments.

Jöst C, Nitsche C, Scholz T, Roux L, Klein CD.

J Med Chem. 2014 Sep 25;57(18):7590-9. doi: 10.1021/jm5006918. Epub 2014 Sep 5.

PMID:
25148591
20.

Thiazolidinone-peptide hybrids as dengue virus protease inhibitors with antiviral activity in cell culture.

Nitsche C, Schreier VN, Behnam MA, Kumar A, Bartenschlager R, Klein CD.

J Med Chem. 2013 Nov 14;56(21):8389-403. doi: 10.1021/jm400828u. Epub 2013 Oct 22.

PMID:
24083834

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