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Items: 1 to 20 of 58


Cryo-EM structure of the Shigella type III needle complex.

Lunelli M, Kamprad A, Bürger J, Mielke T, Spahn CMT, Kolbe M.

PLoS Pathog. 2020 Feb 24;16(2):e1008263. doi: 10.1371/journal.ppat.1008263. eCollection 2020 Feb.


Multifaceted Stoichiometry Control of Bacterial Operons Revealed by Deep Proteome Quantification.

Zhao J, Zhang H, Qin B, Nikolay R, He QY, Spahn CMT, Zhang G.

Front Genet. 2019 May 24;10:473. doi: 10.3389/fgene.2019.00473. eCollection 2019.


Alanine Tails Signal Proteolysis in Bacterial Ribosome-Associated Quality Control.

Lytvynenko I, Paternoga H, Thrun A, Balke A, Müller TA, Chiang CH, Nagler K, Tsaprailis G, Anders S, Bischofs I, Maupin-Furlow JA, Spahn CMT, Joazeiro CAP.

Cell. 2019 Jun 27;178(1):76-90.e22. doi: 10.1016/j.cell.2019.05.002. Epub 2019 May 30.


Structural Basis for the Action of an All-Purpose Transcription Anti-termination Factor.

Krupp F, Said N, Huang YH, Loll B, Bürger J, Mielke T, Spahn CMT, Wahl MC.

Mol Cell. 2019 Apr 4;74(1):143-157.e5. doi: 10.1016/j.molcel.2019.01.016. Epub 2019 Feb 19.


Translatomics: The Global View of Translation.

Zhao J, Qin B, Nikolay R, Spahn CMT, Zhang G.

Int J Mol Sci. 2019 Jan 8;20(1). pii: E212. doi: 10.3390/ijms20010212. Review.


tRNA Translocation by the Eukaryotic 80S Ribosome and the Impact of GTP Hydrolysis.

Flis J, Holm M, Rundlet EJ, Loerke J, Hilal T, Dabrowski M, Bürger J, Mielke T, Blanchard SC, Spahn CMT, Budkevich TV.

Cell Rep. 2018 Dec 4;25(10):2676-2688.e7. doi: 10.1016/j.celrep.2018.11.040.


It takes two transducins to activate the cGMP-phosphodiesterase 6 in retinal rods.

Qureshi BM, Behrmann E, Schöneberg J, Loerke J, Bürger J, Mielke T, Giesebrecht J, Noé F, Lamb TD, Hofmann KP, Spahn CMT, Heck M.

Open Biol. 2018 Aug;8(8). pii: 180075. doi: 10.1098/rsob.180075.


Structural Visualization of the Formation and Activation of the 50S Ribosomal Subunit during In Vitro Reconstitution.

Nikolay R, Hilal T, Qin B, Mielke T, Bürger J, Loerke J, Textoris-Taube K, Nierhaus KH, Spahn CMT.

Mol Cell. 2018 Jun 7;70(5):881-893.e3. doi: 10.1016/j.molcel.2018.05.003. Epub 2018 Jun 7.


Mechanistic insights into the role of prenyl-binding protein PrBP/δ in membrane dissociation of phosphodiesterase 6.

Qureshi BM, Schmidt A, Behrmann E, Bürger J, Mielke T, Spahn CMT, Heck M, Scheerer P.

Nat Commun. 2018 Jan 8;9(1):90. doi: 10.1038/s41467-017-02569-y.


Ribosomal Chamber Music: Toward an Understanding of IRES Mechanisms.

Yamamoto H, Unbehaun A, Spahn CMT.

Trends Biochem Sci. 2017 Aug;42(8):655-668. doi: 10.1016/j.tibs.2017.06.002. Epub 2017 Jul 3. Review.


Photometric assay of maltose and maltose-forming enzyme activity by using 4-alpha-glucanotransferase (DPE2) from higher plants.

Smirnova J, Fernie AR, Spahn CMT, Steup M.

Anal Biochem. 2017 Sep 1;532:72-82. doi: 10.1016/j.ab.2017.05.026. Epub 2017 May 31.


Structural basis for λN-dependent processive transcription antitermination.

Said N, Krupp F, Anedchenko E, Santos KF, Dybkov O, Huang YH, Lee CT, Loll B, Behrmann E, Bürger J, Mielke T, Loerke J, Urlaub H, Spahn CMT, Weber G, Wahl MC.

Nat Microbiol. 2017 Apr 28;2:17062. doi: 10.1038/nmicrobiol.2017.62.


Structural insights into ribosomal rescue by Dom34 and Hbs1 at near-atomic resolution.

Hilal T, Yamamoto H, Loerke J, Bürger J, Mielke T, Spahn CM.

Nat Commun. 2016 Dec 20;7:13521. doi: 10.1038/ncomms13521.


Knud Hermann Nierhaus 1941-2016.

Wilson DN, Spahn CM.

Nat Struct Mol Biol. 2016 Jun 7;23(6):503-4. doi: 10.1038/nsmb.3239. No abstract available.


Structures of ribosome-bound initiation factor 2 reveal the mechanism of subunit association.

Sprink T, Ramrath DJ, Yamamoto H, Yamamoto K, Loerke J, Ismer J, Hildebrand PW, Scheerer P, Bürger J, Mielke T, Spahn CM.

Sci Adv. 2016 Mar 4;2(3):e1501502. doi: 10.1126/sciadv.1501502. eCollection 2016 Mar.


Molecular architecture of the ribosome-bound Hepatitis C Virus internal ribosomal entry site RNA.

Yamamoto H, Collier M, Loerke J, Ismer J, Schmidt A, Hilal T, Sprink T, Yamamoto K, Mielke T, Bürger J, Shaikh TR, Dabrowski M, Hildebrand PW, Scheerer P, Spahn CM.

EMBO J. 2015 Dec 14;34(24):3042-58. doi: 10.15252/embj.201592469. Epub 2015 Nov 24.


Using Molecular Simulation to Model High-Resolution Cryo-EM Reconstructions.

Kirmizialtin S, Loerke J, Behrmann E, Spahn CMT, Sanbonmatsu KY.

Methods Enzymol. 2015;558:497-514. doi: 10.1016/bs.mie.2015.02.011. Epub 2015 May 9.


Structural snapshots of actively translating human ribosomes.

Behrmann E, Loerke J, Budkevich TV, Yamamoto K, Schmidt A, Penczek PA, Vos MR, Bürger J, Mielke T, Scheerer P, Spahn CM.

Cell. 2015 May 7;161(4):845-57. doi: 10.1016/j.cell.2015.03.052.


Ribosome rescue and protein quality control in concert.

Hilal T, Spahn CM.

Mol Cell. 2015 Feb 5;57(3):389-90. doi: 10.1016/j.molcel.2015.01.029.


Cryo-EM of ribosomal 80S complexes with termination factors reveals the translocated cricket paralysis virus IRES.

Muhs M, Hilal T, Mielke T, Skabkin MA, Sanbonmatsu KY, Pestova TV, Spahn CM.

Mol Cell. 2015 Feb 5;57(3):422-32. doi: 10.1016/j.molcel.2014.12.016. Epub 2015 Jan 15.

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