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Old Mice Demonstrate Organ Dysfunction as well as Prolonged Inflammation, Immunosuppression, and Weight Loss in a Modified Surgical Sepsis Model.

Stortz JA, Hollen MK, Nacionales DC, Horiguchi H, Ungaro R, Dirain ML, Wang Z, Wu Q, Wu KK, Kumar A, Foster TC, Stewart BD, Ross JA, Segal M, Bihorac A, Brakenridge S, Moore FA, Wohlgemuth SE, Leeuwenburgh C, Mohr AM, Moldawer LL, Efron PA.

Crit Care Med. 2019 Aug 5. doi: 10.1097/CCM.0000000000003926. [Epub ahead of print]


The Effects of Time Restricted Feeding on Overweight, Older Adults: A Pilot Study.

Anton SD, Lee SA, Donahoo WT, McLaren C, Manini T, Leeuwenburgh C, Pahor M.

Nutrients. 2019 Jun 30;11(7). pii: E1500. doi: 10.3390/nu11071500.


Associations of Weight Change With Changes in Calf Muscle Characteristics and Functional Decline in Peripheral Artery Disease.

Polonsky TS, Tian L, Zhang D, Bazzano LA, Criqui MH, Ferrucci L, Guralnik JM, Kibbe MR, Leeuwenburgh C, Sufit RL, McDermott MM.

J Am Heart Assoc. 2019 Jul 2;8(13):e010890. doi: 10.1161/JAHA.118.010890. Epub 2019 Jun 29.


Prognostic value of NT-proBNP levels in the acute phase of sepsis on lower long-term physical function and muscle strength in sepsis survivors.

Custodero C, Wu Q, Ghita GL, Anton SD, Brakenridge SC, Brumback BA, Efron PA, Gardner AK, Leeuwenburgh C, Moldawer LL, Petersen JW, Moore FA, Mankowski RT.

Crit Care. 2019 Jun 24;23(1):230. doi: 10.1186/s13054-019-2505-7.


Differences in Liver TFAM Binding to mtDNA and mtDNA Damage between Aged and Extremely Aged Rats.

Chimienti G, Picca A, Fracasso F, Marzetti E, Calvani R, Leeuwenburgh C, Russo F, Lezza AMS, Pesce V.

Int J Mol Sci. 2019 May 27;20(10). pii: E2601. doi: 10.3390/ijms20102601.


Glycine supplementation extends lifespan of male and female mice.

Miller RA, Harrison DE, Astle CM, Bogue MA, Brind J, Fernandez E, Flurkey K, Javors M, Ladiges W, Leeuwenburgh C, Macchiarini F, Nelson J, Ryazanov AG, Snyder J, Stearns TM, Vaughan DE, Strong R.

Aging Cell. 2019 Jun;18(3):e12953. doi: 10.1111/acel.12953. Epub 2019 Mar 27.


Targeting mitochondrial quality control for treating sarcopenia: lessons from physical exercise.

Picca A, Calvani R, Leeuwenburgh C, Coelho-Junior HJ, Bernabei R, Landi F, Marzetti E.

Expert Opin Ther Targets. 2019 Feb;23(2):153-160. doi: 10.1080/14728222.2019.1559827. Epub 2018 Dec 22.


Administration of Enalapril Started Late in Life Attenuates Hypertrophy and Oxidative Stress Burden, Increases Mitochondrial Mass, and Modulates Mitochondrial Quality Control Signaling in the Rat Heart.

Picca A, Sirago G, Pesce V, Lezza AMS, Calvani R, Bossola M, Villani ER, Landi F, Leeuwenburgh C, Bernabei R, Carter CS, Marzetti E.

Biomolecules. 2018 Dec 17;8(4). pii: E177. doi: 10.3390/biom8040177.


Effect of losartan and fish oil on plasma IL-6 and mobility in older persons. The ENRGISE Pilot randomized clinical trial.

Pahor M, Anton SD, Beavers DP, Cauley JA, Fielding RA, Kritchevsky SB, Leeuwenburgh C, Lewis KH, Liu CK, Lovato LC, Lu J, Manini TM, McDermott MM, Miller ME, Newman AB, Radziszewska B, Stowe CL, Tracy RP, Walkup MP, Wu SS, Ambrosius WT; ENRGISE study investigators.

J Gerontol A Biol Sci Med Sci. 2018 Dec 12. doi: 10.1093/gerona/gly277. [Epub ahead of print]


Persistent inflammation and anemia among critically ill septic patients.

Loftus TJ, Mira JC, Stortz JA, Ozrazgat-Baslanti T, Ghita GL, Wang Z, Brumback BA, Ungaro RF, Bihorac A, Leeuwenburgh C, Moore FA, Moldawer LL, Brakenridge SC, Efron PA, Mohr AM.

J Trauma Acute Care Surg. 2019 Feb;86(2):260-267. doi: 10.1097/TA.0000000000002147.


HDL inflammatory index correlates with and predicts severity of organ failure in patients with sepsis and septic shock.

Guirgis FW, Dodani S, Leeuwenburgh C, Moldawer L, Bowman J, Kalynych C, Grijalva V, Reddy ST, Jones AE, Moore FA.

PLoS One. 2018 Sep 14;13(9):e0203813. doi: 10.1371/journal.pone.0203813. eCollection 2018.


Mitochondrial quality control mechanisms as molecular targets in cardiac ageing.

Picca A, Mankowski RT, Burman JL, Donisi L, Kim JS, Marzetti E, Leeuwenburgh C.

Nat Rev Cardiol. 2018 Sep;15(9):543-554. doi: 10.1038/s41569-018-0059-z. Review.


Increased TFAM binding to mtDNA damage hot spots is associated with mtDNA loss in aged rat heart.

Chimienti G, Picca A, Sirago G, Fracasso F, Calvani R, Bernabei R, Russo F, Carter CS, Leeuwenburgh C, Pesce V, Marzetti E, Lezza AMS.

Free Radic Biol Med. 2018 Aug 20;124:447-453. doi: 10.1016/j.freeradbiomed.2018.06.041. Epub 2018 Jun 30.


Persistent inflammation, immunosuppression, and catabolism and the development of chronic critical illness after surgery.

Efron PA, Mohr AM, Bihorac A, Horiguchi H, Hollen MK, Segal MS, Baker HV, Leeuwenburgh C, Moldawer LL, Moore FA, Brakenridge SC.

Surgery. 2018 Aug;164(2):178-184. doi: 10.1016/j.surg.2018.04.011. Epub 2018 May 26. Review.


Loss of sirtuin 1 and mitofusin 2 contributes to enhanced ischemia/reperfusion injury in aged livers.

Chun SK, Lee S, Flores-Toro J, U RY, Yang MJ, Go KL, Biel TG, Miney CE, Pierre Louis S, Law BK, Law ME, Thomas EM, Behrns KE, Leeuwenburgh C, Kim JS.

Aging Cell. 2018 Aug;17(4):e12761. doi: 10.1111/acel.12761. Epub 2018 May 17.


The "BIOmarkers associated with Sarcopenia and PHysical frailty in EldeRly pErsons" (BIOSPHERE) study: Rationale, design and methods.

Calvani R, Picca A, Marini F, Biancolillo A, Cesari M, Pesce V, Lezza AMS, Bossola M, Leeuwenburgh C, Bernabei R, Landi F, Marzetti E.

Eur J Intern Med. 2018 Oct;56:19-25. doi: 10.1016/j.ejim.2018.05.001. Epub 2018 May 10.


Peripheral artery disease, calf skeletal muscle mitochondrial DNA copy number, and functional performance.

McDermott MM, Peterson CA, Sufit R, Ferrucci L, Guralnik JM, Kibbe MR, Polonsky TS, Tian L, Criqui MH, Zhao L, Stein JH, Li L, Leeuwenburgh C.

Vasc Med. 2018 Aug;23(4):340-348. doi: 10.1177/1358863X18765667. Epub 2018 May 8.


Persistent injury-associated anemia and aging: Novel insights.

Loftus TJ, Kannan KB, Carter CS, Plazas JM, Mira JC, Brakenridge SC, Leeuwenburgh C, Efron PA, Mohr AM.

J Trauma Acute Care Surg. 2018 Mar;84(3):490-496. doi: 10.1097/TA.0000000000001766.


Persistent injury-associated anemia in aged rats.

Loftus TJ, Kannan KB, Carter CS, Plazas JM, Mira JC, Brakenridge SC, Leeuwenburgh C, Efron PA, Mohr AM.

Exp Gerontol. 2018 Mar;103:63-68. doi: 10.1016/j.exger.2018.01.001. Epub 2018 Jan 4.


Benchmarking clinical outcomes and the immunocatabolic phenotype of chronic critical illness after sepsis in surgical intensive care unit patients.

Stortz JA, Mira JC, Raymond SL, Loftus TJ, Ozrazgat-Baslanti T, Wang Z, Ghita GL, Leeuwenburgh C, Segal MS, Bihorac A, Brumback BA, Mohr AM, Efron PA, Moldawer LL, Moore FA, Brakenridge SC.

J Trauma Acute Care Surg. 2018 Feb;84(2):342-349. doi: 10.1097/TA.0000000000001758.

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