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Items: 12

1.

Small-Molecule Inhibition of Rho/MKL/SRF Transcription in Prostate Cancer Cells: Modulation of Cell Cycle, ER Stress, and Metastasis Gene Networks.

Evelyn CR, Lisabeth EM, Wade SM, Haak AJ, Johnson CN, Lawlor ER, Neubig RR.

Microarrays (Basel). 2016 May 28;5(2). pii: E13. doi: 10.3390/microarrays5020013.

2.

Targeting substrate-site in Jak2 kinase prevents emergence of genetic resistance.

Kesarwani M, Huber E, Kincaid Z, Evelyn CR, Biesiada J, Rance M, Thapa MB, Shah NP, Meller J, Zheng Y, Azam M.

Sci Rep. 2015 Sep 30;5:14538. doi: 10.1038/srep14538.

3.

Combined rational design and a high throughput screening platform for identifying chemical inhibitors of a Ras-activating enzyme.

Evelyn CR, Biesiada J, Duan X, Tang H, Shang X, Papoian R, Seibel WL, Nelson S, Meller J, Zheng Y.

J Biol Chem. 2015 May 15;290(20):12879-98. doi: 10.1074/jbc.M114.634493. Epub 2015 Mar 30.

4.

Rational design of small molecule inhibitors targeting the Ras GEF, SOS1.

Evelyn CR, Duan X, Biesiada J, Seibel WL, Meller J, Zheng Y.

Chem Biol. 2014 Dec 18;21(12):1618-28. doi: 10.1016/j.chembiol.2014.09.018. Epub 2014 Nov 20.

5.

Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors.

Shang X, Marchioni F, Evelyn CR, Sipes N, Zhou X, Seibel W, Wortman M, Zheng Y.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3155-60. doi: 10.1073/pnas.1212324110. Epub 2013 Feb 4.

6.

Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases.

Shang X, Marchioni F, Sipes N, Evelyn CR, Jerabek-Willemsen M, Duhr S, Seibel W, Wortman M, Zheng Y.

Chem Biol. 2012 Jun 22;19(6):699-710. doi: 10.1016/j.chembiol.2012.05.009.

7.

Small-molecule targeting of proliferating cell nuclear antigen chromatin association inhibits tumor cell growth.

Tan Z, Wortman M, Dillehay KL, Seibel WL, Evelyn CR, Smith SJ, Malkas LH, Zheng Y, Lu S, Dong Z.

Mol Pharmacol. 2012 Jun;81(6):811-9. doi: 10.1124/mol.112.077735. Epub 2012 Mar 7.

8.

Design, synthesis and prostate cancer cell-based studies of analogs of the Rho/MKL1 transcriptional pathway inhibitor, CCG-1423.

Evelyn CR, Bell JL, Ryu JG, Wade SM, Kocab A, Harzdorf NL, Showalter HD, Neubig RR, Larsen SD.

Bioorg Med Chem Lett. 2010 Jan 15;20(2):665-72. doi: 10.1016/j.bmcl.2009.11.056. Epub 2009 Nov 18.

9.

A conserved hydrophobic surface of the LARG pleckstrin homology domain is critical for RhoA activation in cells.

Aittaleb M, Gao G, Evelyn CR, Neubig RR, Tesmer JJ.

Cell Signal. 2009 Nov;21(11):1569-78. doi: 10.1016/j.cellsig.2009.06.003. Epub 2009 Jun 26.

10.

High-throughput screening for small-molecule inhibitors of LARG-stimulated RhoA nucleotide binding via a novel fluorescence polarization assay.

Evelyn CR, Ferng T, Rojas RJ, Larsen MJ, Sondek J, Neubig RR.

J Biomol Screen. 2009 Feb;14(2):161-72. doi: 10.1177/1087057108328761. Epub 2009 Feb 4.

11.

Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs.

Lutz S, Shankaranarayanan A, Coco C, Ridilla M, Nance MR, Vettel C, Baltus D, Evelyn CR, Neubig RR, Wieland T, Tesmer JJ.

Science. 2007 Dec 21;318(5858):1923-7.

12.

CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling.

Evelyn CR, Wade SM, Wang Q, Wu M, Iñiguez-Lluhí JA, Merajver SD, Neubig RR.

Mol Cancer Ther. 2007 Aug;6(8):2249-60.

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