Format

Send to

Choose Destination
  • Showing results for a modified search because your search retrieved no results.
Clin Drug Investig. 2013 Apr;33(4):263-74. doi: 10.1007/s40261-013-0063-3.

A multinational, observational study to investigate the efficacy, safety and tolerability of acarbose as add-on or monotherapy in a range of patients: the Gluco VIP study.

Collaborators (783)

Abbass Z, Abdus Sattar J, Abdurahman T, Abid R, Adhiwana S, Adi Utama L, Agarwal R, Ahmad BI, Ahmad S, Ahmad M, Ahmed B, Ahmed R, Ahmed U, Ahmed M, Ahn C, Ahn C, Ahn J, Ahn K, Akbani S, Akhter A, Akram M, Alajbegovic S, Alam R, Alampayan M, Ali S, Ali M, Ali Awan M, Ali Choudhary I, Ali Sheikh A, Ali Sheikh K, Alip M, Alphanto W, Alves J, Ambhore S, Aminwala M, An M, Andriani L, Andag-Silva A, Ang A, Anhua L, Antonio A, Aouali R, Aouiche S, Apit S, Aquino J, Arain M, Arifiyanto I, Ashraf B, Ashraf F, Atmosutarjo S, Au C, Auliati S, Awan H, Babakaeva A, Babbar P, Bachtiarwati A, Baculao E, Bagiyan I, Bai Y, Baik T, Baloch F, Baldemor D, Banerjee J, Barykina I, Basri H, Batavia I, Bavishi R, Benazzouz M, Bespalova T, Bey A, Bhar P, Bhattacharya S, Bien T, Bin W, Borovcanin D, Bong C, Bongirwar V, Bova E, Bullo J, Butar-Butar R, Butt J, Cao A, Cao H, Carpio B, Carreon R, Ceric K, Cha S, Chagay N, Chajjer K, Chan P, Chan D, Chan N, Chan N, Chan W, Chandramohan P, Chandra S, Chang K, Chao X, Chauhan S, Chea T, Cheng H, Cheong A, Cheung A, Chey S, Chi K, Chi Y, Chin Y, Chin K, Cho E, Cho H, Cho YW, Choi BK, Choi BI, Choi DH, Choi DS, Choi I, Choi S, Choi WS, Chong L, Chua A, Chun HC, Chun R, Chung C, Chung J, Chung SC, Cimafranca A, Crisostomo M, Cui C, Custodio M, Cutillar C, Dabir H, Darmawi S, Darwis D, Das R, Datta K, Dela Cruz T, Deng W, Deole M, Deshpande S, Devan KS, Dewant D, Dewi M, Dilber S, Dimatatac G, Dirjayanto A, Dizdarevic A, Djukanovic Z, Djukanovic I, Duero D, Dudareva L, Duong Tan T, Echavia A, Egorova V, Escalante V, Esparagoza C, Eugenio B, Evuru S, Fababier R, Farooq D, Farooqi D, Fatimah F, Fei T, Feng Z, Fengming Z, Filatova O, Florece M, Fomina S, Fu Q, Fuaad M, Gafate-Ong M, Gamallo E, Gan M, Gang W, Gao F, Gao J, Gao L, Gatchalian E, Gatchalian A, Gavran L, Ghaffar A, Ghuman D, Gilani H, Glen L, Goh B, Goingco R, Goingco H, Goingco O, Gondal M, Gong M, Gopalkrishna N, Guan S, Guanzon V, Gundran N, Guo Y, Guo J, Guo J, Guo Y, Gupta A, Gupta M, Gupta P, Gupta S, Gupta S, Gustiawan D, Gutierrez M, Guz L, Ha S, Hafeez A, Haleem A, Ham S, Hameed A, Han J, Han J, Han K, Hartono T, Hassan Khan M, Hendrawan D, Herawati N, Hermanto S, Hermawan D, Hindradi W, Hong KS, Hong T, Hong Z, Hongshu X, Hor S, Ho Thi O, Hu F, Hu H, Hua W, Hua R, Huang C, Huang T, Huh H, Hussain S, Hussain S, Hwang H, Ibrahimpasic-Srna K, Ijaz M, Ikhsan R, Indiyah I, Iqbal I, Iqbal N, Irfan M, Irfan M, Iskandar I, Ismai S, Ivashina E, Jameel R, Jain S, Jain S, Jain S, Jain V, Jardeleza R, Jayabal A, Jeganathan Pulogana-than H, Jeon J, Jeong T, Jeremic L, Ji R, Jian X, Jiandao Y, Jian H, Ju Q, Jung M, Jung Y, Kahloon E, Kang H, Kang H, Kartikawati N, Kasnawi K, Katarzhanskaya T, Katarzhanskiy V, Kathiresan Pillai N, Kayalvizhi S, Khalid A, Khan A, Khan D, Khan D, Khan S, Khan K, Kheng K, Khoo Y, Ki S, Kim D, Kim G, Kim H, Kim I, Kim J, Kim J, Kim J, Kim J, Kim JM, Kim K, Kim K, Kim M, Kim P, Kim S, Kim S, Kim S, Kim T, Kim T, Kim Y, Kim Y, Kim Y, Kim Y, Kim Y, Kim Y, Kiranmayi P, Kiranmayi P, Ko S, Koh C, Kolenda D, Kothari L, Korpusova I, Kow G, Krasilnikova T, Kravchak A, Krishan V, Krishna A, Kujundzic-Vatrenjak F, Kumar A, Kustagi AL, Kuswanto I, Kwan G, Kwak H, Kwok S, Kwon J, Ku J, Kudinov V, Kumar P, Kung Lim S, Kustova N, Kuzmina L, Lal Khatri A, Latha RM, Lana W, Lasmaria R, Lazatin T, Lee BI, Lee H, Lee J, Lee J, Lee K, Lee K, Lee S, Lee S, Lee S, Lee S, Lee S, Lee S, Lee W, Lee Y, Lee Y, Legaspi M, Lei X, Lestantyo D, Li D, Li G, Li J, Li K, Li L, Li R, Li W, Li X, Li Y, Li Y, Liang W, Liang B, Liang G, Liang Z, Liannawati L, Lin X, Lin X, Ling H, Ling W, Lim C, Lim S, Lim W, Lipnicevic S, Lismayani I, Liu C, Liu H, Liu H, Liu J, Liu J, Liu S, Liu S, Liu W, Liu Z, Liu Y, Lohano V, Lontoc M, Lou X, Lu J, Lucas-Linga R, Lumbun N, Lusida J, Luo Y, Lv X, Lyu S, Ma L, Madni A, Magaling C, Magtolis L, Mahfooz Khan I, Mahfudz F, Mahmud R, Majeed L, Mak W, Makhrova O, Malaki L, Malik Z, Malis S, Mamaril R, Mao L, Marbibi A, Maria Victoria D, Mariani M, Martinez E, Martinus S, Markovic R, Masood D, Meenakshi S, Megherbi M, Mei Wulan M, Membrere M, Memon A, Memon Q, Miao G, Miklukova V, Minoun L, Min Z, Minina I, Mishra A, Mirasol R, Miyan Z, Mokhtar Mehni R, Monilisa M, Mondal S, Moon J, Moon S, Mosbah Boulenmour S, Muhammad A, Mugiarti S, Mukherjee S, Mukti S, Muljati S, Mulyono D, Munir A, Mutha A, Mushtaq A, Music-Palalic I, Mustafic D, Nam Ko S, Naeem A, Ng K, Ngan S, Ngo Thanh N, Nguyen Thi Bich V, Nguyen Thi Ngoc H, Nguyen Thu H, Nguyen Thuy T, Niu X, Nidagundi K, Nizami U, Nicodemus J, Oh C, Oh J, Oh N, Oh T, Onga O, Orakzai N, Orba Busro V, Pan X, Pande T, Pandian M, Panelo A, Pang Z, Pangphilova D, Paredes F, Parikh K, Parikh P, Park H, Park J, Park J, Park J, Park J, Park K, Park S, Pascasio B, Patange S, Pathan A, Peng I, Peregrino E, Pham Thuy H, Philip E, Ponce R, Prabowo P, Prajitno E, Prasad B, Prnjavorac D, Purnomo R, Purwanti P, Purwono R, Puspitarani D, Puspitawati I, Qiaomin W, Qin X, Qing D, Qinyong Y, Radic B, Rafiq K, Ragavan D, Rahayu W, Rane N, Rasool G, Rasool T, Rathi K, Ravishankar AG, Raza A, Rehman F, Remaldora M, Ringkananont U, Rizal W, Rozajac J, Roziiati J, Ryu O, Saeed T, Sagoro D, Sakrani A, Salihovic H, Sangguna A, Sangsayudh N, Santoso A, Santos F, Sapang B, Savenkova N, Selimovic S, Selvakumar P, Selvapandian P, Sembiring D, Semilla N, Seng S, Sentosa S, Septia D, Serebrennikova E, Setijo H, Setiogung B, Shah JD, Shah K, Shamkaeva R, Shan Y, Shani D, Shao Z, Sheikh D, Shi Y, Shin D, Shin S, Shoaib Qureshi S, Shmeleva E, Shuai W, Shubing I, Shujuan Y, Shun X, Shun Y, Shunkai Z, Shurigin V, Si W, Simatuang E, Singh H, Singh NP, Singh P, Singh P, Singh R, Singh R, Sinorita H, Sinuraya G, Sohail D, Sok B, Som L, Son KH, Song S, Soon C, Sor D, Sreetharanathan R, Srimanarayana K, Srivasta H, Srivastav S, Srivastav SB, Stevanovic R, Storozhok M, Sudjono S, Suh J, Sulijc S, Sulistiyanto H, Sum S, Supinto S, Suprayitno S, Sura-amornkul S, Surya A, Suryabudhi E, Suryaminah S, Susilo WH, Sutanto I, Suwarni I, Syam P, Synanyan T, Tabangcura P, Tack Y, Tahir S, Talla C, Tama K, Tan C, Tan G, Tan G, Tan L, Tan M, Tanchoco E, Tanumihardja B, Tanweer A, Tarasova V, Tarueno A, Tarwani H, Tat C, Teoh K, Teow R, Terzic M, The P, Thomas J, Tiu F, Tkachenko E, Tobing D, Tokic F, Tolentino M, Tong P, Tongson R, Toor H, Toreja T, Touch K, Tsang C, Tsang K, Tsvetkovskaya T, Tran Thi Thanh H, Trivedi S, Tulod E, Tuo H, Turmukhambetova B, Ud-din M, Ugalino C, Un H, Ur-Rehman N, Usman N, Vagapova G, Vaichulis O, Vaja C, Valdez G, Valdez M, Valerio J, Vanja S, Verdillo L, Verma K, VIllar R, Villenskaya G, Vithalani M, Vladimirova T, Vorobyev S, Wang C, Wang D, Wang D, Wang F, Wang F, Wang H, Wang I, Wang N, Wang W, Wang X, Wang X, Wang Y, Wangi H, Wanharni W, Wardaha A, Wardhani T, Warraich D, Wei A, Wei F, Wei H, Weifang H, Weiguo H, Weijia Z, Wenyan W, Wenyong S, Wenzhao W, Widayati W, Widjayani A, Widjojo S, Widura W, Widya Saputra L, Winantea A, Wiyono H, Won S, Wong A, Wong C, Wong C, Wong K, Wong T, Wong T, Wongso M, Wu J, Wu S, Wu X, Xia J, Xiao W, Xiaowen C, Xiaoyan C, Xiaoying Z, Zin N, Xiushi N, Xu Z, Xu Z, Xu A, Xu N, Xu Y, Xuefeng D, Edi SY, Yadav A, Yahya N, Yakhou M, Yang G, Yang N, Yang S, Yao C, Yazdani Khan K, Ye I, Ye Y, Yew F, Yii K, Yimin S, Yong I, Yong Y, Yousuf J, Yu J, Yuan H, Yueping W, Yu-Gan S, Yun K, Yun S, Yun T, Yuneva G, Yuwu Z, Yuyou Z, Zhai Z, Zhang C, Zhang D, Zhang G, Zhang G, Zhang H, Zhang J, Zhang N, Zhang R, Zhang W, Zhang X, Zhang X, Zhang X, Zhang X, Zhang Y, Zhang Z, Zhao H, Zhao H, Zhao Y, Zhao Z, Zhimin W, Zhong C, Zhou J, Zhou I, Zhou X, Zhou Y, Zhu Y, Zhuhua Z, Zainab Z, Zaffar J, Zahid N, Zaidi S, Zia F.

Abstract

BACKGROUND AND OBJECTIVES:

The burden of type 2 diabetes mellitus is growing rapidly, particularly in the Asia-Pacific region. The aim of this international, large-scale, observational study was to investigate the efficacy and tolerability of the antidiabetic agent acarbose as add-on or monotherapy in a range of patients with type 2 diabetes, including those with cardiovascular morbidities. The majority of practices were included from high-burden regions (predominantly those in the Asia-Pacific region).

METHODS:

This was an observational study conducted in 15 countries/regions. Adults with pre-treated or untreated type 2 diabetes prescribed acarbose as add-on or monotherapy were eligible. Two-hour postprandial blood glucose (2-h PPG), glycosylated haemoglobin (HbA1c) and fasting blood glucose (FBG) were measured over a 3-month observation period.

RESULTS:

A total of 15,034 patients were valid for the efficacy analysis and 15,661 for the safety analysis (mean age was 57.6 years and 92.6 % of patients were Asian). Mean (SD) 2-h PPG decreased by -71.9 (62.3) mg/dL, to 170.2 (46.5) mg/dL at final visit (after 12.8 [4.1] weeks). Mean HbA1c decreased by -1.1 % (1.3) to 7.2 % (1.1) and mean FBG decreased by -33.0 (43.3) mg/dL to 124.8 (30.5) mg/dL. Acarbose was effective regardless of the presence of cardiovascular co-morbidities or diabetic complications. The efficacy of acarbose was rated 'very good' or 'good' in 85.5 % of patients, and tolerability as 'very good' or 'good' in 84.9 % of patients. Drug-related adverse events, mainly gastrointestinal, were reported in 490/15,661 patients (3.13 %).

CONCLUSION:

The results of this observational study support the notion that acarbose is effective, safe and well tolerated in a large cohort of Asian patients with type 2 diabetes.

PMID:
23435929
DOI:
10.1007/s40261-013-0063-3
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center