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Protective effect of Fisetin against angiotensin II-induced apoptosis by activation of IGF-IR-PI3K-Akt signaling in H9c2 cells and spontaneous hypertension rats.

Chen YP, Sivalingam K, Shibu MA, Peramaiyan R, Day CH, Shen CY, Lai CH, Chen RJ, Viswanadha VP, Chen YF, Huang CY.

Phytomedicine. 2018 Sep 17;57:1-8. doi: 10.1016/j.phymed.2018.09.179. [Epub ahead of print]


ROS- and HIF1α-dependent IGFBP3 upregulation blocks IGF1 survival signaling and thereby mediates high-glucose-induced cardiomyocyte apoptosis.

Huang YT, Liu CH, Yang YC, Aneja R, Wen SY, Huang CY, Kuo WW.

J Cell Physiol. 2019 Jan 19. doi: 10.1002/jcp.28034. [Epub ahead of print]


Exercise training augments Sirt1-signaling and attenuates cardiac inflammation in D-galactose induced-aging rats.

Chen WK, Tsai YL, Shibu MA, Shen CY, Chang-Lee SN, Chen RJ, Yao CH, Ban B, Kuo WW, Huang CY.

Aging (Albany NY). 2018 Dec 23;10(12):4166-4174. doi: 10.18632/aging.101714.


CXCL2/CXCR2 axis induces cancer stem cell characteristics in CPT-11-resistant LoVo colon cancer cells via Gαi-2 and Gαq/11.

Chen MC, Baskaran R, Lee NH, Hsu HH, Ho TJ, Tu CC, Lin YM, Viswanadha VP, Kuo WW, Huang CY.

J Cell Physiol. 2018 Dec 14. doi: 10.1002/jcp.27891. [Epub ahead of print]


Alpinate Oxyphyllae extracts enhance the longevity and homing of mesenchymal stem cells and augment their protection against senescence in H9c2 cells.

Chang YM, Asokan Shibu M, Tsai CT, Tsai CC, Lin SL, Chang CC, Viswanadha VP, Chen RJ, Chang JH, Huang CY.

J Cell Physiol. 2018 Dec 4. doi: 10.1002/jcp.27867. [Epub ahead of print]


Overexpression of IGF-IIRα regulates cardiac remodeling and aggravates high salt induced apoptosis and fibrosis in transgenic rats.

Chang RL, Nithiyanantham S, Kuo WW, Pai PY, Chang TT, Lai CH, Chen RJ, Vijaya Padma V, Huang CY, Huang CY.

Environ Toxicol. 2019 Feb;34(2):210-218. doi: 10.1002/tox.22676. Epub 2018 Nov 18.


Upregulation of tumor PD-L1 by neoadjuvant chemoradiotherapy (neoCRT) confers improved survival in patients with lymph node metastasis of locally advanced rectal cancers.

Chiang SF, Huang CY, Ke TW, Chen TW, Lan YC, You YS, Chen WT, Chao KSC.

Cancer Immunol Immunother. 2019 Feb;68(2):283-296. doi: 10.1007/s00262-018-2275-0. Epub 2018 Nov 17.


Fabrication of (111)-Oriented Nanotwinned Au Films for Au-to-Au Direct Bonding.

Wu JA, Huang CY, Wu WW, Chen C.

Materials (Basel). 2018 Nov 15;11(11). pii: E2287. doi: 10.3390/ma11112287.


Tumorous imaginal disc 1 (TID1) inhibits isoproterenol-induced cardiac hypertrophy and apoptosis by regulating c-terminus of hsc70-interacting protein (CHIP) mediated degradation of Gαs.

Feng CC, Liao PH, Tsai HI, Cheng SM, Yang LY, PadmaViswanadha V, Pan LF, Chen RJ, Lo JF, Huang CY.

Int J Med Sci. 2018 Oct 20;15(13):1537-1546. doi: 10.7150/ijms.24296. eCollection 2018.


Neferine suppresses diethylnitrosamine-induced lung carcinogenesis in Wistar rats.

Sivalingam K, Amirthalingam V, Ganasan K, Huang CY, Viswanadha VP.

Food Chem Toxicol. 2019 Jan;123:385-398. doi: 10.1016/j.fct.2018.11.014. Epub 2018 Nov 10.


Alpinia oxyphylla Miq extract ameliorates cardiac fibrosis associated with D-galactose induced aging in rats.

Chang YM, Tamilselvi S, Lin HJ, Tsai CC, Lin YM, Day CH, Viswanadha VP, Chang HN, Kuo WW, Huang CY.

Environ Toxicol. 2019 Feb;34(2):172-178. doi: 10.1002/tox.22671. Epub 2018 Oct 27.


Can mesenchymal stem cell lysate reverse aging?

Hsu MF, Yu SH, Chuang SJ, Kuo TK, Singal PK, Huang CY, Kao CL, Kuo CH.

Aging (Albany NY). 2018 Oct 24;10(10):2900-2910. doi: 10.18632/aging.101595.


Clinical significance of programmed death 1 ligand-1 (CD274/PD-L1) and intra-tumoral CD8+ T-cell infiltration in stage II-III colorectal cancer.

Huang CY, Chiang SF, Ke TW, Chen TW, You YS, Chen WT, Chao KSC.

Sci Rep. 2018 Oct 23;8(1):15658. doi: 10.1038/s41598-018-33927-5.


Deep Ocean Minerals Minimize Eccentric Exercise-Induced Inflammatory Response of Rat Skeletal Muscle.

Saovieng S, Wu J, Huang CY, Kao CL, Higgins MF, Chuanchaiyakul R, Kuo CH.

Front Physiol. 2018 Sep 28;9:1351. doi: 10.3389/fphys.2018.01351. eCollection 2018.


HMGB1 promotes ERK-mediated mitochondrial Drp1 phosphorylation for chemoresistance through RAGE in colorectal cancer.

Huang CY, Chiang SF, Chen WT, Ke TW, Chen TW, You YS, Lin CY, Chao KSC, Huang CY.

Cell Death Dis. 2018 Sep 26;9(10):1004. doi: 10.1038/s41419-018-1019-6.


Oral administration of alcalase potato protein hydrolysate-APPH attenuates high fat diet-induced cardiac complications via TGF-β/GSN axis in aging rats.

Hu WS, Ting WJ, Tamilselvi S, Day CH, Wang T, Chiang WD, Viswanadha VP, Yeh YL, Lin WT, Huang CY.

Environ Toxicol. 2019 Jan;34(1):5-12. doi: 10.1002/tox.22651. Epub 2018 Sep 21.


Cryptotanshinone (Dsh-003) from Salvia miltiorrhiza Bunge inhibits prostaglandin E2-induced survival and invasion effects in HA22T hepatocellular carcinoma cells.

Chang JH, Lin CH, Shibu MA, Chou YC, Liu JY, Chou YH, Shen CY, Yeh YL, Viswanadha VP, Huang CY.

Environ Toxicol. 2018 Dec;33(12):1254-1260. doi: 10.1002/tox.22633. Epub 2018 Sep 12.


Observing Solid-State Formation of Oriented Porous Functional Oxide Nanowire Heterostructures by in Situ TEM.

Ho JH, Ting YH, Chen JY, Huang CW, Tsai TC, Lin TY, Huang CY, Wu WW.

Nano Lett. 2018 Aug 27. doi: 10.1021/acs.nanolett.8b03021. [Epub ahead of print]


Inhibition of ERK-Drp1 signaling and mitochondria fragmentation alleviates IGF-IIR-induced mitochondria dysfunction during heart failure.

Huang CY, Lai CH, Kuo CH, Chiang SF, Pai PY, Lin JY, Chang CF, Viswanadha VP, Kuo WW, Huang CY.

J Mol Cell Cardiol. 2018 Sep;122:58-68. doi: 10.1016/j.yjmcc.2018.08.006. Epub 2018 Aug 9.


Bioactive Peptide Improves Diet-Induced Hepatic Fat Deposition and Hepatocyte Proinflammatory Response in SAMP8 Ageing Mice.

Dumeus S, Shibu MA, Lin WT, Wang MF, Lai CH, Shen CY, Lin YM, Viswanadha VP, Kuo WW, Huang CY.

Cell Physiol Biochem. 2018;48(5):1942-1952. doi: 10.1159/000492518. Epub 2018 Aug 9.

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