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Items: 1 to 20 of 58


Improvement of Skin Penetration, Antipollutant Activity and Skin Hydration of 7,3',4'-Trihydroxyisoflavone Cyclodextrin Inclusion Complex.

Huang PH, Hu SCS, Yen FL, Tseng CH.

Pharmaceutics. 2019 Aug 8;11(8). pii: E399. doi: 10.3390/pharmaceutics11080399.


Discovery of Furanoquinone Derivatives as a Novel Class of DNA Polymerase and Gyrase Inhibitors for MRSA Eradication in Cutaneous Infection.

Yang SC, Tang KW, Lin CH, Alalaiwe A, Tseng CH, Fang JY.

Front Microbiol. 2019 May 29;10:1197. doi: 10.3389/fmicb.2019.01197. eCollection 2019.


Discovery of 2-Substituted 3-Arylquinoline Derivatives as Potential Anti-Inflammatory Agents Through Inhibition of LPS-Induced Inflammatory Responses in Macrophages.

Yang CY, Hung YL, Tang KW, Wang SC, Tseng CH, Tzeng CC, Liu PL, Li CY, Chen YL.

Molecules. 2019 Mar 23;24(6). pii: E1162. doi: 10.3390/molecules24061162.


Liposomal Avicequinone-B formulations: Aqueous solubility, physicochemical properties and apoptotic effects on cutaneous squamous cell carcinoma cells.

Hu SC, Su YS, Lai YC, Tseng CH, Yen FL.

Phytomedicine. 2019 May;58:152870. doi: 10.1016/j.phymed.2019.152870. Epub 2019 Feb 18.


Phytochemical naphtho[1,2-b] furan-4,5‑dione induced topoisomerase II-mediated DNA damage response in human non-small-cell lung cancer.

Chien CM, Yang JC, Wu PH, Wu CY, Chen GY, Wu YC, Chou CK, Tseng CH, Chen YL, Wang LF, Chiu CC.

Phytomedicine. 2019 Feb 15;54:109-119. doi: 10.1016/j.phymed.2018.06.025. Epub 2018 Jun 28.


Discovery of 3-Amino-2-Hydroxypropoxyisoflavone Derivatives as Potential Anti-HCV Agents.

Lee JC, Lin CK, Tseng CK, Chen YL, Tzeng CC, Tseng CH.

Molecules. 2018 Nov 2;23(11). pii: E2863. doi: 10.3390/molecules23112863.


Pharmacological inhibition of bacterial β-glucuronidase prevents irinotecan-induced diarrhea without impairing its antitumor efficacy in vivo.

Cheng KW, Tseng CH, Tzeng CC, Leu YL, Cheng TC, Wang JY, Chang JM, Lu YC, Cheng CM, Chen IJ, Cheng YA, Chen YL, Cheng TL.

Pharmacol Res. 2019 Jan;139:41-49. doi: 10.1016/j.phrs.2018.10.029. Epub 2018 Nov 1.


Synthesis and Biological Evaluation of Thalidomide Derivatives as Potential Anti-Psoriasis Agents.

Tang KW, Lin ZC, Chen YL, Tzeng CC, Fang JY, Tseng CH.

Int J Mol Sci. 2018 Oct 7;19(10). pii: E3061. doi: 10.3390/ijms19103061.


Preparation, characterizations and anti-pollutant activity of 7,3',4'-trihydroxyisoflavone nanoparticles in particulate matter-induced HaCaT keratinocytes.

Huang PH, Tseng CH, Lin CY, Lee CW, Yen FL.

Int J Nanomedicine. 2018 Jun 1;13:3279-3293. doi: 10.2147/IJN.S153323. eCollection 2018.


Discovery of Pyrazolo[4,3-c]quinolines Derivatives as Potential Anti-Inflammatory Agents through Inhibiting of NO Production.

Tseng CH, Tung CW, Peng SI, Chen YL, Tzeng CC, Cheng CM.

Molecules. 2018 Apr 28;23(5). pii: E1036. doi: 10.3390/molecules23051036.


Discovery of naphtho[1,2-d]oxazole derivatives as potential anti-HCV agents through inducing heme oxygenase-1 expression.

Tseng CH, Lin CK, Chen YL, Tseng CK, Lee JY, Lee JC.

Eur J Med Chem. 2018 Jan 1;143:970-982. doi: 10.1016/j.ejmech.2017.12.006. Epub 2017 Dec 5.


Specific Inhibition of Bacterial β-Glucuronidase by Pyrazolo[4,3-c]quinoline Derivatives via a pH-Dependent Manner To Suppress Chemotherapy-Induced Intestinal Toxicity.

Cheng KW, Tseng CH, Yang CN, Tzeng CC, Cheng TC, Leu YL, Chuang YC, Wang JY, Lu YC, Chen YL, Cheng TL.

J Med Chem. 2017 Nov 22;60(22):9222-9238. doi: 10.1021/acs.jmedchem.7b00963. Epub 2017 Nov 9.


Discovery of novel diarylpyrazolylquinoline derivatives as potent anti-dengue virus agents.

Lee JC, Tseng CK, Lin CK, Tseng CH.

Eur J Med Chem. 2017 Dec 1;141:282-292. doi: 10.1016/j.ejmech.2017.10.001. Epub 2017 Oct 3.


Naphtho[1,2-b]furan-4,5-dione is a potent anti-MRSA agent against planktonic, biofilm and intracellular bacteria.

Yang SC, Yen FL, Wang PW, Aljuffali IA, Weng YH, Tseng CH, Fang JY.

Future Microbiol. 2017 Sep;12:1059-1073. doi: 10.2217/fmb-2017-0044. Epub 2017 Aug 11.


Pterostilbene, a Methoxylated Resveratrol Derivative, Efficiently Eradicates Planktonic, Biofilm, and Intracellular MRSA by Topical Application.

Yang SC, Tseng CH, Wang PW, Lu PL, Weng YH, Yen FL, Fang JY.

Front Microbiol. 2017 Jun 13;8:1103. doi: 10.3389/fmicb.2017.01103. eCollection 2017.


Discovery of Indeno[1,2-c]quinoline Derivatives as Potent Dual Antituberculosis and Anti-Inflammatory Agents.

Tseng CH, Tung CW, Wu CH, Tzeng CC, Chen YH, Hwang TL, Chen YL.

Molecules. 2017 Jun 16;22(6). pii: E1001. doi: 10.3390/molecules22061001.


Dual roles of extracellular signal-regulated kinase (ERK) in quinoline compound BPIQ-induced apoptosis and anti-migration of human non-small cell lung cancer cells.

Fong Y, Wu CY, Chang KF, Chen BH, Chou WJ, Tseng CH, Chen YC, Wang HD, Chen YL, Chiu CC.

Cancer Cell Int. 2017 Mar 7;17:37. doi: 10.1186/s12935-017-0403-0. eCollection 2017.


9-bis[2-(pyrrolidin-1-yl)ethoxy]-6-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-11H-indeno[1, 2-c]quinolin-11-one (BPIQ), A Quinoline Derivative Inhibits Human Hepatocellular Carcinoma Cells by Inducing ER Stress and Apoptosis.

Chang WT, Fong Y, Chuang SC, Chou CK, Chou HL, Yang CF, Tseng CH, Chen YL, Chiu CC.

Anticancer Agents Med Chem. 2017;17(5):692-700. doi: 10.2174/1871520616666160802121456.


TCH1036, a indeno[1,2-c]quinoline derivative, potentially inhibited the growth of human brain malignant glioma (GBM) 8401 cells via suppression of the expression of Suv39h1 and PARP.

Liao HF, Lee CC, Hsiao PC, Chen YF, Tseng CH, Tzeng CC, Chen YL, Chen JC, Chang YS, Chang JG.

Biomed Pharmacother. 2016 Aug;82:649-59. doi: 10.1016/j.biopha.2016.06.002. Epub 2016 Jun 13.


Design of acid-responsive polymeric nanoparticles for 7,3',4'-trihydroxyisoflavone topical administration.

Huang PH, Hu SC, Lee CW, Yeh AC, Tseng CH, Yen FL.

Int J Nanomedicine. 2016 Apr 18;11:1615-27. doi: 10.2147/IJN.S100418. eCollection 2016.

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