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Items: 1 to 20 of 43

1.

Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy.

Lee J, Termglinchan V, Diecke S, Itzhaki I, Lam CK, Garg P, Lau E, Greenhaw M, Seeger T, Wu H, Zhang JZ, Chen X, Gil IP, Ameen M, Sallam K, Rhee JW, Churko JM, Chaudhary R, Chour T, Wang PJ, Snyder MP, Chang HY, Karakikes I, Wu JC.

Nature. 2019 Aug;572(7769):335-340. doi: 10.1038/s41586-019-1406-x. Epub 2019 Jul 17.

PMID:
31316208
2.

Modelling diastolic dysfunction in induced pluripotent stem cell-derived cardiomyocytes from hypertrophic cardiomyopathy patients.

Wu H, Yang H, Rhee JW, Zhang JZ, Lam CK, Sallam K, Chang ACY, Ma N, Lee J, Zhang H, Blau HM, Bers DM, Wu JC.

Eur Heart J. 2019 Jun 20. pii: ehz326. doi: 10.1093/eurheartj/ehz326. [Epub ahead of print]

PMID:
31219556
3.

Identifying the Transcriptome Signatures of Calcium Channel Blockers in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Lam CK, Tian L, Belbachir N, Wnorowski A, Shrestha R, Ma N, Kitani T, Rhee JW, Wu JC.

Circ Res. 2019 Jul 5;125(2):212-222. doi: 10.1161/CIRCRESAHA.118.314202. Epub 2019 May 13.

PMID:
31079550
4.

A Human iPSC Double-Reporter System Enables Purification of Cardiac Lineage Subpopulations with Distinct Function and Drug Response Profiles.

Zhang JZ, Termglinchan V, Shao NY, Itzhaki I, Liu C, Ma N, Tian L, Wang VY, Chang ACY, Guo H, Kitani T, Wu H, Lam CK, Kodo K, Sayed N, Blau HM, Wu JC.

Cell Stem Cell. 2019 May 2;24(5):802-811.e5. doi: 10.1016/j.stem.2019.02.015. Epub 2019 Mar 14.

PMID:
30880024
5.

Human-Induced Pluripotent Stem Cell Model of Trastuzumab-Induced Cardiac Dysfunction in Patients With Breast Cancer.

Kitani T, Ong SG, Lam CK, Rhee JW, Zhang JZ, Oikonomopoulos A, Ma N, Tian L, Lee J, Telli ML, Witteles RM, Sharma A, Sayed N, Wu JC.

Circulation. 2019 May 21;139(21):2451-2465. doi: 10.1161/CIRCULATIONAHA.118.037357.

PMID:
30866650
6.

A Premature Termination Codon Mutation in MYBPC3 Causes Hypertrophic Cardiomyopathy via Chronic Activation of Nonsense-Mediated Decay.

Seeger T, Shrestha R, Lam CK, Chen C, McKeithan WL, Lau E, Wnorowski A, McMullen G, Greenhaw M, Lee J, Oikonomopoulos A, Lee S, Yang H, Mercola M, Wheeler M, Ashley EA, Yang F, Karakikes I, Wu JC.

Circulation. 2019 Feb 5;139(6):799-811. doi: 10.1161/CIRCULATIONAHA.118.034624.

PMID:
30586709
7.

Disease modelling and drug discovery for hypertrophic cardiomyopathy using pluripotent stem cells: how far have we come?

Lam CK, Wu JC.

Eur Heart J. 2018 Nov 14;39(43):3893-3895. doi: 10.1093/eurheartj/ehy388. No abstract available.

PMID:
30010924
8.

Genome Editing of Induced Pluripotent Stem Cells to Decipher Cardiac Channelopathy Variant.

Garg P, Oikonomopoulos A, Chen H, Li Y, Lam CK, Sallam K, Perez M, Lux RL, Sanguinetti MC, Wu JC.

J Am Coll Cardiol. 2018 Jul 3;72(1):62-75. doi: 10.1016/j.jacc.2018.04.041.

9.

Determining the Pathogenicity of a Genomic Variant of Uncertain Significance Using CRISPR/Cas9 and Human-Induced Pluripotent Stem Cells.

Ma N, Zhang JZ, Itzhaki I, Zhang SL, Chen H, Haddad F, Kitani T, Wilson KD, Tian L, Shrestha R, Wu H, Lam CK, Sayed N, Wu JC.

Circulation. 2018 Dec 4;138(23):2666-2681. doi: 10.1161/CIRCULATIONAHA.117.032273.

PMID:
29914921
10.

A novel human S10F-Hsp20 mutation induces lethal peripartum cardiomyopathy.

Liu GS, Gardner G, Adly G, Jiang M, Cai WF, Lam CK, Alogaili F, Robbins N, Rubinstein J, Kranias EG.

J Cell Mol Med. 2018 May 15. doi: 10.1111/jcmm.13665. [Epub ahead of print]

11.

HAX-1 regulates SERCA2a oxidation and degradation.

Bidwell PA, Liu GS, Nagarajan N, Lam CK, Haghighi K, Gardner G, Cai WF, Zhao W, Mugge L, Vafiadaki E, Sanoudou D, Rubinstein J, Lebeche D, Hajjar R, Sadoshima J, Kranias EG.

J Mol Cell Cardiol. 2018 Jan;114:220-233. doi: 10.1016/j.yjmcc.2017.11.014. Epub 2017 Nov 21.

12.

Regulation of BECN1-mediated autophagy by HSPB6: Insights from a human HSPB6S10F mutant.

Liu GS, Zhu H, Cai WF, Wang X, Jiang M, Essandoh K, Vafiadaki E, Haghighi K, Lam CK, Gardner G, Adly G, Nicolaou P, Sanoudou D, Liang Q, Rubinstein J, Fan GC, Kranias EG.

Autophagy. 2018;14(1):80-97. doi: 10.1080/15548627.2017.1392420. Epub 2018 Jan 29.

13.

Patient-Specific and Genome-Edited Induced Pluripotent Stem Cell-Derived Cardiomyocytes Elucidate Single-Cell Phenotype of Brugada Syndrome.

Liang P, Sallam K, Wu H, Li Y, Itzhaki I, Garg P, Zhang Y, Vermglinchan V, Lan F, Gu M, Gong T, Zhuge Y, He C, Ebert AD, Sanchez-Freire V, Churko J, Hu S, Sharma A, Lam CK, Scheinman MM, Bers DM, Wu JC.

J Am Coll Cardiol. 2016 Nov 8;68(19):2086-2096. doi: 10.1016/j.jacc.2016.07.779.

14.

Five New Cytotoxic Metabolites from the Marine Fungus Neosartorya pseudofischeri.

Lan WJ, Fu SJ, Xu MY, Liang WL, Lam CK, Zhong GH, Xu J, Yang DP, Li HJ.

Mar Drugs. 2016 Jan 13;14(1):18. doi: 10.3390/md14010018.

15.

HAX-1 regulates cyclophilin-D levels and mitochondria permeability transition pore in the heart.

Lam CK, Zhao W, Liu GS, Cai WF, Gardner G, Adly G, Kranias EG.

Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):E6466-75. doi: 10.1073/pnas.1508760112. Epub 2015 Nov 9.

16.

Human G109E-inhibitor-1 impairs cardiac function and promotes arrhythmias.

Haghighi K, Pritchard TJ, Liu GS, Singh VP, Bidwell P, Lam CK, Vafiadaki E, Das P, Ma J, Kunduri S, Sanoudou D, Florea S, Vanderbilt E, Wang HS, Rubinstein J, Hajjar RJ, Kranias EG.

J Mol Cell Cardiol. 2015 Dec;89(Pt B):349-59. doi: 10.1016/j.yjmcc.2015.10.004. Epub 2015 Oct 9.

17.

Cobalt(II) amido complexes derived from a monodentate arylamido ligand featuring a highly electron-withdrawing C6F5 substituent.

Yao S, Tam DY, Cheung PS, Lam CK, Guo P, Lam SL, Lee HK.

Dalton Trans. 2015 Nov 7;44(41):17950-9. doi: 10.1039/c5dt00796h. Epub 2015 Sep 29.

PMID:
26418474
18.

Up-regulation of micro-RNA765 in human failing hearts is associated with post-transcriptional regulation of protein phosphatase inhibitor-1 and depressed contractility.

Cai WF, Liu GS, Lam CK, Florea S, Qian J, Zhao W, Pritchard T, Haghighi K, Lebeche D, Lu LJ, Deng J, Fan GC, Hajjar RJ, Kranias EG.

Eur J Heart Fail. 2015 Aug;17(8):782-93. doi: 10.1002/ejhf.323. Epub 2015 Jul 15.

19.

Synthesis, characterization, photophysics, and anion binding properties of platinum(ii) acetylide complexes with urea group.

Zhang ZH, Liu J, Wan LQ, Jiang FR, Lam CK, Ye BH, Qiao Z, Chao HY.

Dalton Trans. 2015 May 7;44(17):7785-96. doi: 10.1039/c5dt00307e.

PMID:
25855366
20.

A novel human R25C-phospholamban mutation is associated with super-inhibition of calcium cycling and ventricular arrhythmia.

Liu GS, Morales A, Vafiadaki E, Lam CK, Cai WF, Haghighi K, Adly G, Hershberger RE, Kranias EG.

Cardiovasc Res. 2015 Jul 1;107(1):164-74. doi: 10.1093/cvr/cvv127. Epub 2015 Apr 7.

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