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Items: 18


Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK.

Li M, Zhang CS, Zong Y, Feng JW, Ma T, Hu M, Lin Z, Li X, Xie C, Wu Y, Jiang D, Li Y, Zhang C, Tian X, Wang W, Yang Y, Chen J, Cui J, Wu YQ, Chen X, Liu QF, Wu J, Lin SY, Ye Z, Liu Y, Piao HL, Yu L, Zhou Z, Xie XS, Hardie DG, Lin SC.

Cell Metab. 2019 Sep 3;30(3):508-524.e12. doi: 10.1016/j.cmet.2019.05.018. Epub 2019 Jun 13.


Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress.

Zong Y, Zhang CS, Li M, Wang W, Wang Z, Hawley SA, Ma T, Feng JW, Tian X, Qi Q, Wu YQ, Zhang C, Ye Z, Lin SY, Piao HL, Hardie DG, Lin SC.

Cell Res. 2019 Jun;29(6):460-473. doi: 10.1038/s41422-019-0163-6. Epub 2019 Apr 4.


Carbohydrates: Not All that Bad?

Lin SY, Zhang CS, Lin SC.

Cell Metab. 2018 Nov 6;28(5):671-672. doi: 10.1016/j.cmet.2018.10.004.


Glutaminase GLS1 senses glutamine availability in a non-enzymatic manner triggering mitochondrial fusion.

Cai WF, Zhang C, Wu YQ, Zhuang G, Ye Z, Zhang CS, Lin SC.

Cell Res. 2018 Aug;28(8):865-867. doi: 10.1038/s41422-018-0057-z. Epub 2018 Jun 22. No abstract available.


Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate.

Li TY, Song L, Sun Y, Li J, Yi C, Lam SM, Xu D, Zhou L, Li X, Yang Y, Zhang CS, Xie C, Huang X, Shui G, Lin SY, Reue K, Lin SC.

Nat Commun. 2018 May 15;9(1):1916. doi: 10.1038/s41467-018-04363-w.


AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity.

Luo H, Jiang M, Lian G, Liu Q, Shi M, Li TY, Song L, Ye J, He Y, Yao L, Zhang C, Lin ZZ, Zhang CS, Zhao TJ, Jia WP, Li P, Lin SY, Lin SC.

Cell Metab. 2018 Apr 3;27(4):843-853.e6. doi: 10.1016/j.cmet.2018.02.021.


Determining AMPK Activation via the Lysosomal v-ATPase-Ragulator-AXIN/LKB1 Axis.

Zhang CS, Li M, Zong Y, Lin SC.

Methods Mol Biol. 2018;1732:393-411. doi: 10.1007/978-1-4939-7598-3_25.


Structural and Dynamic Insights into the Mechanism of Allosteric Signal Transmission in ERK2-Mediated MKP3 Activation.

Lu C, Liu X, Zhang CS, Gong H, Wu JW, Wang ZX.

Biochemistry. 2017 Nov 21;56(46):6165-6175. doi: 10.1021/acs.biochem.7b00827. Epub 2017 Nov 8.


Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK.

Zhang CS, Hawley SA, Zong Y, Li M, Wang Z, Gray A, Ma T, Cui J, Feng JW, Zhu M, Wu YQ, Li TY, Ye Z, Lin SY, Yin H, Piao HL, Hardie DG, Lin SC.

Nature. 2017 Aug 3;548(7665):112-116. doi: 10.1038/nature23275. Epub 2017 Jul 19.


Metformin Activates AMPK through the Lysosomal Pathway.

Zhang CS, Li M, Ma T, Zong Y, Cui J, Feng JW, Wu YQ, Lin SY, Lin SC.

Cell Metab. 2016 Oct 11;24(4):521-522. doi: 10.1016/j.cmet.2016.09.003. No abstract available.


ULK1/2 Constitute a Bifurcate Node Controlling Glucose Metabolic Fluxes in Addition to Autophagy.

Li TY, Sun Y, Liang Y, Liu Q, Shi Y, Zhang CS, Zhang C, Song L, Zhang P, Zhang X, Li X, Chen T, Huang HY, He X, Wang Y, Wu YQ, Chen S, Jiang M, Chen C, Xie C, Yang JY, Lin Y, Zhao S, Ye Z, Lin SY, Chiu DT, Lin SC.

Mol Cell. 2016 May 5;62(3):359-370. doi: 10.1016/j.molcel.2016.04.009.


A conserved motif in JNK/p38-specific MAPK phosphatases as a determinant for JNK1 recognition and inactivation.

Liu X, Zhang CS, Lu C, Lin SC, Wu JW, Wang ZX.

Nat Commun. 2016 Mar 18;7:10879. doi: 10.1038/ncomms10879.


AMPK Promotes Autophagy by Facilitating Mitochondrial Fission.

Zhang CS, Lin SC.

Cell Metab. 2016 Mar 8;23(3):399-401. doi: 10.1016/j.cmet.2016.02.017.


RHOBTB3 promotes proteasomal degradation of HIF╬▒ through facilitating hydroxylation and suppresses the Warburg effect.

Zhang CS, Liu Q, Li M, Lin SY, Peng Y, Wu D, Li TY, Fu Q, Jia W, Wang X, Ma T, Zong Y, Cui J, Pu C, Lian G, Guo H, Ye Z, Lin SC.

Cell Res. 2015 Sep;25(9):1025-42. doi: 10.1038/cr.2015.90. Epub 2015 Jul 28.


The lysosomal v-ATPase-Ragulator complex is a common activator for AMPK and mTORC1, acting as a switch between catabolism and anabolism.

Zhang CS, Jiang B, Li M, Zhu M, Peng Y, Zhang YL, Wu YQ, Li TY, Liang Y, Lu Z, Lian G, Liu Q, Guo H, Yin Z, Ye Z, Han J, Wu JW, Yin H, Lin SY, Lin SC.

Cell Metab. 2014 Sep 2;20(3):526-40. doi: 10.1016/j.cmet.2014.06.014. Epub 2014 Jul 4.


AMP as a low-energy charge signal autonomously initiates assembly of AXIN-AMPK-LKB1 complex for AMPK activation.

Zhang YL, Guo H, Zhang CS, Lin SY, Yin Z, Peng Y, Luo H, Shi Y, Lian G, Zhang C, Li M, Ye Z, Ye J, Han J, Li P, Wu JW, Lin SC.

Cell Metab. 2013 Oct 1;18(4):546-55. doi: 10.1016/j.cmet.2013.09.005.


Protein phosphorylation-acetylation cascade connects growth factor deprivation to autophagy.

Lin SY, Li TY, Liu Q, Zhang C, Li X, Chen Y, Zhang SM, Lian G, Liu Q, Ruan K, Wang Z, Zhang CS, Chien KY, Wu J, Li Q, Han J, Lin SC.

Autophagy. 2012 Sep;8(9):1385-6. doi: 10.4161/auto.20959. Epub 2012 Jun 21.


GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy.

Lin SY, Li TY, Liu Q, Zhang C, Li X, Chen Y, Zhang SM, Lian G, Liu Q, Ruan K, Wang Z, Zhang CS, Chien KY, Wu J, Li Q, Han J, Lin SC.

Science. 2012 Apr 27;336(6080):477-81. doi: 10.1126/science.1217032. Erratum in: Science. 2012 Aug 17;337(6096):799.

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