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Materials (Basel). 2017 Feb 27;10(3). pii: E228. doi: 10.3390/ma10030228.

In Vitro Evaluation of Dentin Tubule Occlusion for Novel Calcium Lactate Phosphate (CLP) Paste.

Yang JC1,2, Hu HT3, Lee SY4,5,6, Hsieh SC7,8, Huang PC9, Ma CF10, Ji DY11, Chang LY12, Teng NC13,14.

Author information

1
Graduate Institute of Nanomedicine and Medical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11052, Taiwan. yang820065@tmu.edu.tw.
2
Center for Teeth Bank and Dental Stem Cell Technology, Taipei Medical University, Taipei 11052, Taiwan. yang820065@tmu.edu.tw.
3
School of Dentistry, Taipei Medical University, Taipei 11052, Taiwan. hsintaihu1011@hotmail.com.
4
Center for Teeth Bank and Dental Stem Cell Technology, Taipei Medical University, Taipei 11052, Taiwan. seanlee@tmu.edu.tw.
5
School of Dentistry, Taipei Medical University, Taipei 11052, Taiwan. seanlee@tmu.edu.tw.
6
Dental Department of Wan-Fang Hospital, Taipei Medical University, Taipei 11052, Taiwan. seanlee@tmu.edu.tw.
7
School of Dentistry, Taipei Medical University, Taipei 11052, Taiwan. endo@tmu.edu.tw.
8
Dental Department of Wan-Fang Hospital, Taipei Medical University, Taipei 11052, Taiwan. endo@tmu.edu.tw.
9
Dental Department of Wan-Fang Hospital, Taipei Medical University, Taipei 11052, Taiwan.
10
Graduate Institute of Biomedical Materials and Engineering, Taipei Medical University, Taipei 11052, Taiwan.
11
School of Dentistry, Taipei Medical University, Taipei 11052, Taiwan. alkjjj@gmail.com.
12
Graduate Institute of Nanomedicine and Medical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11052, Taiwan. alex627324@gmail.com.
13
School of Dentistry, Taipei Medical University, Taipei 11052, Taiwan. dianaten@tmu.edu.tw.
14
Dental Department, Taipei Medical University Hospital, Taipei 11052, Taiwan. dianaten@tmu.edu.tw.

Abstract

INTRODUCTION:

The objective of this in vitro study is to evaluate the effective and long-term occlusion of dentinal tubules using a novel calcium lactate phosphate (CLP) based desensitizing agent.

METHODS:

Dentin disks (n = 9) were pre-etched using 1 M lactic acid for 30 s and individually treated with Colgate® Pro-Relief™ paste, CLP paste, and double distilled water (ddH₂O) by a rubber-cupped handpiece. Dentin disks were analyzed under optical micrographs for pre-treatment, directly after treatment, and 14 days post-treatment. One-way ANOVA and post-hoc Tukey's test were used to determine whether there were any statistically significant differences in dentinal tubule diameter.

RESULTS:

A significant decrease occurred in the mean tubule diameter for dentin disks treated with CLP paste. A decrease was observed from 3.52 ± 0.83 µm to 2.62 ± 0.42 µm right after treatment, further decreasing to 1.71 ± 0.45 µm after immersion in artificial saliva for 14 days (p < 0.05).

CONCLUSIONS:

The results suggest that the CLP based desensitizing paste has remineralization properties and provides instant and lasting effectiveness in dentinal tubule occlusion.

KEYWORDS:

calcium lactate phosphate (CLP); dentin hypersensitivity; desensitizing agent

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