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Items: 1 to 20 of 31


Generation of Highly Efficient Equine-Derived Antibodies for Post-Exposure Treatment of Ricin Intoxications by Vaccination with Monomerized Ricin.

Falach R, Sapoznikov A, Alcalay R, Aftalion M, Ehrlich S, Makovitzki A, Agami A, Mimran A, Rosner A, Sabo T, Kronman C, Gal Y.

Toxins (Basel). 2018 Nov 12;10(11). pii: E466. doi: 10.3390/toxins10110466.


Early disruption of the alveolar-capillary barrier in a ricin-induced ARDS mouse model: neutrophil-dependent and -independent impairment of junction proteins.

Sapoznikov A, Gal Y, Falach R, Sagi I, Ehrlich S, Lerer E, Makovitzki A, Aloshin A, Kronman C, Sabo T.

Am J Physiol Lung Cell Mol Physiol. 2019 Jan 1;316(1):L255-L268. doi: 10.1152/ajplung.00300.2018. Epub 2018 Nov 1.


Treatments for Pulmonary Ricin Intoxication: Current Aspects and Future Prospects.

Gal Y, Mazor O, Falach R, Sapoznikov A, Kronman C, Sabo T.

Toxins (Basel). 2017 Oct 3;9(10). pii: E311. doi: 10.3390/toxins9100311. Review.


Total Body Irradiation Mitigates Inflammation and Extends the Therapeutic Time Window for Anti-Ricin Antibody Treatment against Pulmonary Ricinosis in Mice.

Gal Y, Sapoznikov A, Falach R, Ehrlich S, Aftalion M, Kronman C, Sabo T.

Toxins (Basel). 2017 Sep 11;9(9). pii: E278. doi: 10.3390/toxins9090278.


Improved antibody-based ricin neutralization by affinity maturation is correlated with slower off-rate values.

Rosenfeld R, Alcalay R, Mechaly A, Lapidoth G, Epstein E, Kronman C, J Fleishman S, Mazor O.

Protein Eng Des Sel. 2017 Sep 1;30(9):611-617. doi: 10.1093/protein/gzx028.


Extended therapeutic window for post-exposure treatment of ricin intoxication conferred by the use of high-affinity antibodies.

Noy-Porat T, Alcalay R, Epstein E, Sabo T, Kronman C, Mazor O.

Toxicon. 2017 Mar 1;127:100-105. doi: 10.1016/j.toxicon.2017.01.009. Epub 2017 Jan 12.


A novel swine model of ricin-induced acute respiratory distress syndrome.

Katalan S, Falach R, Rosner A, Goldvaser M, Brosh-Nissimov T, Dvir A, Mizrachi A, Goren O, Cohen B, Gal Y, Sapoznikov A, Ehrlich S, Sabo T, Kronman C.

Dis Model Mech. 2017 Feb 1;10(2):173-183. doi: 10.1242/dmm.027847. Epub 2017 Jan 6.


Potent Antiedematous and Protective Effects of Ciprofloxacin in Pulmonary Ricinosis.

Gal Y, Sapoznikov A, Falach R, Ehrlich S, Aftalion M, Sabo T, Kronman C.

Antimicrob Agents Chemother. 2016 Nov 21;60(12):7153-7158. Print 2016 Dec.


Quantitative profiling of the in vivo enzymatic activity of ricin reveals disparate depurination of different pulmonary cell types.

Falach R, Sapoznikov A, Gal Y, Israeli O, Leitner M, Seliger N, Ehrlich S, Kronman C, Sabo T.

Toxicol Lett. 2016 Sep 6;258:11-19. doi: 10.1016/j.toxlet.2016.06.003. Epub 2016 Jun 11.


Ricin-Holotoxin-Based Vaccines: Induction of Potent Ricin-Neutralizing Antibodies.

Sabo T, Kronman C, Mazor O.

Methods Mol Biol. 2016;1403:683-94. doi: 10.1007/978-1-4939-3387-7_38.


Isolation of Anti-Ricin Protective Antibodies Exhibiting High Affinity from Immunized Non-Human Primates.

Noy-Porat T, Rosenfeld R, Ariel N, Epstein E, Alcalay R, Zvi A, Kronman C, Ordentlich A, Mazor O.

Toxins (Basel). 2016 Mar 3;8(3). pii: E64. doi: 10.3390/toxins8030064.


Diverse profiles of ricin-cell interactions in the lung following intranasal exposure to ricin.

Sapoznikov A, Falach R, Mazor O, Alcalay R, Gal Y, Seliger N, Sabo T, Kronman C.

Toxins (Basel). 2015 Nov 17;7(11):4817-31. doi: 10.3390/toxins7114817.


Antibody treatment against pulmonary exposure to abrin confers significantly higher levels of protection than treatment against ricin intoxication.

Sabo T, Gal Y, Elhanany E, Sapoznikov A, Falach R, Mazor O, Kronman C.

Toxicol Lett. 2015 Sep 2;237(2):72-8. doi: 10.1016/j.toxlet.2015.06.003. Epub 2015 Jun 5.


Rapid assessment of antibody-induced ricin neutralization by employing a novel functional cell-based assay.

Gal Y, Alcalay R, Sabo T, Noy-Porat T, Epstein E, Kronman C, Mazor O.

J Immunol Methods. 2015 Sep;424:136-9. doi: 10.1016/j.jim.2015.05.005. Epub 2015 May 21.


Characterization and epitope mapping of the polyclonal antibody repertoire elicited by ricin holotoxin-based vaccination.

Cohen O, Mechaly A, Sabo T, Alcalay R, Aloni-Grinstein R, Seliger N, Kronman C, Mazor O.

Clin Vaccine Immunol. 2014 Nov;21(11):1534-40. doi: 10.1128/CVI.00510-14. Epub 2014 Sep 10.


Antibody/doxycycline combined therapy for pulmonary ricinosis: Attenuation of inflammation improves survival of ricin-intoxicated mice.

Gal Y, Mazor O, Alcalay R, Seliger N, Aftalion M, Sapoznikov A, Falach R, Kronman C, Sabo T.

Toxicol Rep. 2014 Aug 1;1:496-504. doi: 10.1016/j.toxrep.2014.07.013. eCollection 2014.


Next generation OP-bioscavengers: a circulatory long-lived 4-PEG hypolysine mutant of F338A-HuAChE with optimal pharmacokinetics and pseudo-catalytic characteristics.

Kronman C, Cohen O, Mazor O, Ordentlich A, Raveh L, Velan B, Shafferman A.

Chem Biol Interact. 2010 Sep 6;187(1-3):253-8. doi: 10.1016/j.cbi.2009.12.004. Epub 2009 Dec 11.


Aging-resistant organophosphate bioscavenger based on polyethylene glycol-conjugated F338A human acetylcholinesterase.

Mazor O, Cohen O, Kronman C, Raveh L, Stein D, Ordentlich A, Shafferman A.

Mol Pharmacol. 2008 Sep;74(3):755-63. doi: 10.1124/mol.108.047449. Epub 2008 Jun 3.


Flexibility versus "rigidity" of the functional architecture of AChE active center.

Shafferman A, Barak D, Stein D, Kronman C, Velan B, Greig NH, Ordentlich A.

Chem Biol Interact. 2008 Sep 25;175(1-3):166-72. doi: 10.1016/j.cbi.2008.03.013. Epub 2008 Apr 8.


Controlled concealment of exposed clearance and immunogenic domains by site-specific polyethylene glycol attachment to acetylcholinesterase hypolysine mutants.

Cohen O, Kronman C, Lazar A, Velan B, Shafferman A.

J Biol Chem. 2007 Dec 7;282(49):35491-501. Epub 2007 Oct 11.

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