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Items: 1 to 20 of 35

1.

The synthetic flavanone 6-methoxy-2-(naphthalen-1-yl)chroman-4-one induces apoptosis and activation of the MAPK pathway in human U-937 leukaemia cells.

Saavedra E, Del Rosario H, Brouard I, Hernández-Garcés J, García C, Quintana J, Estévez F.

Bioorg Chem. 2020 Jan;94:103450. doi: 10.1016/j.bioorg.2019.103450. Epub 2019 Nov 21.

PMID:
31785856
2.

The E6/E7 oncogenes of human papilloma virus and estradiol regulate hedgehog signaling activity in a murine model of cervical cancer.

Rojo-León V, García C, Valencia C, Méndez MA, Wood C, Covarrubias L.

Exp Cell Res. 2019 Aug 15;381(2):311-322. doi: 10.1016/j.yexcr.2019.05.024. Epub 2019 May 21.

PMID:
31125556
3.

Reduced lifespan of mice lacking catalase correlates with altered lipid metabolism without oxidative damage or premature aging.

Pérez-Estrada JR, Hernández-García D, Leyva-Castro F, Ramos-León J, Cuevas-Benítez O, Díaz-Muñoz M, Castro-Obregón S, Ramírez-Solís R, García C, Covarrubias L.

Free Radic Biol Med. 2019 May 1;135:102-115. doi: 10.1016/j.freeradbiomed.2019.02.016. Epub 2019 Feb 25.

PMID:
30818059
4.

Glioblastoma Therapy in the Age of Molecular Medicine.

Geraldo LHM, Garcia C, da Fonseca ACC, Dubois LGF, de Sampaio E Spohr TCL, Matias D, de Camargo Magalhães ES, do Amaral RF, da Rosa BG, Grimaldi I, Leser FS, Janeiro JM, Macharia L, Wanjiru C, Pereira CM, Moura-Neto V, Freitas C, Lima FRS.

Trends Cancer. 2019 Jan;5(1):46-65. doi: 10.1016/j.trecan.2018.11.002. Epub 2018 Dec 7. Review.

PMID:
30616755
5.

Stereoselective Synthesis of Highly Substituted Tetrahydropyrans through an Evans Aldol-Prins Strategy.

Álvarez-Méndez SJ, Fariña-Ramos M, Villalba ML, Perretti MD, García C, Moujir LM, Ramírez MA, Martín VS.

J Org Chem. 2018 Aug 17;83(16):9039-9066. doi: 10.1021/acs.joc.8b01182. Epub 2018 Aug 6.

PMID:
30036470
6.

3'-Hydroxy-3,4'-dimethoxyflavone-induced cell death in human leukaemia cells is dependent on caspases and reactive oxygen species and attenuated by the inhibition of JNK/SAPK.

Estévez-Sarmiento F, Hernández E, Brouard I, León F, García C, Quintana J, Estévez F.

Chem Biol Interact. 2018 May 25;288:1-11. doi: 10.1016/j.cbi.2018.04.006. Epub 2018 Apr 6.

PMID:
29630880
7.

3'-Hydroxy-3,4'-dimethoxyflavone blocks tubulin polymerization and is a potent apoptotic inducer in human SK-MEL-1 melanoma cells.

Estévez-Sarmiento F, Said M, Brouard I, León F, García C, Quintana J, Estévez F.

Bioorg Med Chem. 2017 Nov 1;25(21):6060-6070. doi: 10.1016/j.bmc.2017.09.043. Epub 2017 Oct 3.

PMID:
29032930
8.

Microglia in Cancer: For Good or for Bad?

da Fonseca AC, Amaral R, Garcia C, Geraldo LH, Matias D, Lima FR.

Adv Exp Med Biol. 2016;949:245-261. Review.

PMID:
27714693
9.

Gardenin B-induced cell death in human leukemia cells involves multiple caspases but is independent of the generation of reactive oxygen species.

Cabrera J, Saavedra E, Del Rosario H, Perdomo J, Loro JF, Cifuente DA, Tonn CE, García C, Quintana J, Estévez F.

Chem Biol Interact. 2016 Aug 25;256:220-7. doi: 10.1016/j.cbi.2016.07.016. Epub 2016 Jul 14.

PMID:
27423764
10.

The Evans Aldol-Prins cyclization: a general and stereoselective method for the synthesis of 2,3,4,5,6-pentasubstituted tetrahydropyrans.

Álvarez-Méndez SJ, García C, Martín VS.

Chem Commun (Camb). 2016 Feb 25;52(16):3380-3. doi: 10.1039/c6cc00160b.

PMID:
26878814
11.

Oxasqualenoids from Laurencia viridis: Combined Spectroscopic-Computational Analysis and Antifouling Potential.

Cen-Pacheco F, Santiago-Benítez AJ, García C, Álvarez-Méndez SJ, Martín-Rodríguez AJ, Norte M, Martín VS, Gavín JA, Fernández JJ, Daranas AH.

J Nat Prod. 2015 Apr 24;78(4):712-21. doi: 10.1021/np5008922. Epub 2015 Mar 17.

PMID:
25781558
12.

A new iridoid, verbascoside and derivatives with inhibitory activity against Taq DNA polymerase.

Garro HA, García C, Martín VS, Tonn CE, Pungitore CR.

Bioorg Med Chem Lett. 2015 Feb 15;25(4):914-8. doi: 10.1016/j.bmcl.2014.12.052. Epub 2014 Dec 23.

PMID:
25582597
13.

The orthotopic xenotransplant of human glioblastoma successfully recapitulates glioblastoma-microenvironment interactions in a non-immunosuppressed mouse model.

Garcia C, Dubois LG, Xavier AL, Geraldo LH, da Fonseca AC, Correia AH, Meirelles F, Ventura G, Romão L, Canedo NH, de Souza JM, de Menezes JR, Moura-Neto V, Tovar-Moll F, Lima FR.

BMC Cancer. 2014 Dec 8;14:923. doi: 10.1186/1471-2407-14-923.

14.

The impact of microglial activation on blood-brain barrier in brain diseases.

da Fonseca AC, Matias D, Garcia C, Amaral R, Geraldo LH, Freitas C, Lima FR.

Front Cell Neurosci. 2014 Nov 3;8:362. doi: 10.3389/fncel.2014.00362. eCollection 2014. Review.

15.

Chemistry and biological activity of coumarins at molecular level.

Garro HA, García C, Martín VS, Tonn CE, Pungitore CR.

Nat Prod Commun. 2014 Aug;9(8):1091-4.

PMID:
25233580
16.

Derivatives of grindelic acid: from a non-active natural diterpene to synthetic antitumor derivatives.

Reta GF, Chiaramello AI, García C, León LG, Martín VS, Padrón JM, Tonn CE, Donadel OJ.

Eur J Med Chem. 2013 Sep;67:28-38. doi: 10.1016/j.ejmech.2013.06.013. Epub 2013 Jun 18.

PMID:
23831507
17.

Requirement of phosphorylatable endothelial nitric oxide synthase at Ser-1177 for vasoinhibin-mediated inhibition of endothelial cell migration and proliferation in vitro.

García C, Nuñez-Anita RE, Thebault S, Arredondo Zamarripa D, Jeziorsky MC, Martínez de la Escalera G, Clapp C.

Endocrine. 2014 Mar;45(2):263-70. doi: 10.1007/s12020-013-9964-4. Epub 2013 May 3.

PMID:
23640371
18.

Equinatoxin II potentiates temozolomide- and etoposide-induced glioblastoma cell death.

Kahn SA, Biasoli D, Garcia C, Geraldo LH, Pontes B, Sobrinho M, Frauches AC, Romão L, Soletti RC, Assunção Fdos S, Tovar-Moll F, de Souza JM, Lima FR, Anderluh G, Moura-Neto V.

Curr Top Med Chem. 2012;12(19):2082-93.

PMID:
23167797
19.

Glioblastoma: therapeutic challenges, what lies ahead.

Lima FR, Kahn SA, Soletti RC, Biasoli D, Alves T, da Fonseca AC, Garcia C, Romão L, Brito J, Holanda-Afonso R, Faria J, Borges H, Moura-Neto V.

Biochim Biophys Acta. 2012 Dec;1826(2):338-49. doi: 10.1016/j.bbcan.2012.05.004. Epub 2012 Jun 5. Review.

PMID:
22677165
20.

On the configuration of five-membered rings: a spin-spin coupling constant approach.

Napolitano JG, Gavín JA, García C, Norte M, Fernández JJ, Daranas AH.

Chemistry. 2011 May 27;17(23):6338-47. doi: 10.1002/chem.201100412. Epub 2011 May 5.

PMID:
21547972

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