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Items: 1 to 20 of 33

1.

Effect of the point mutation H54N on the ferroxidase process of Rana catesbeiana H' ferritin.

Pozzi C, Di Pisa F, Lalli D, Rosa C, Turano P, Mangani S.

J Inorg Biochem. 2019 Aug;197:110697. doi: 10.1016/j.jinorgbio.2019.110697. Epub 2019 May 7.

PMID:
31075719
2.

Targeting Methyltransferases in Human Pathogenic Bacteria: Insights into Thymidylate Synthase (TS) and Flavin-Dependent TS (FDTS).

Pozzi C, Lopresti L, Tassone G, Mangani S.

Molecules. 2019 Apr 25;24(8). pii: E1638. doi: 10.3390/molecules24081638. Review.

3.

Structural Insights into the Development of Cycloguanil Derivatives as Trypanosoma brucei Pteridine-Reductase-1 Inhibitors.

Landi G, Linciano P, Borsari C, Bertolacini CP, Moraes CB, Cordeiro-da-Silva A, Gul S, Witt G, Kuzikov M, Costi MP, Pozzi C, Mangani S.

ACS Infect Dis. 2019 May 1. doi: 10.1021/acsinfecdis.8b00358. [Epub ahead of print]

PMID:
31012301
4.

Evidence of Destabilization of the Human Thymidylate Synthase (hTS) Dimeric Structure Induced by the Interface Mutation Q62R.

Pozzi C, Lopresti L, Santucci M, Costi MP, Mangani S.

Biomolecules. 2019 Apr 3;9(4). pii: E134. doi: 10.3390/biom9040134.

5.

Structural and Functional Characterization of the Human Thymidylate Synthase (hTS) Interface Variant R175C, New Perspectives for the Development of hTS Inhibitors.

Pozzi C, Ferrari S, Luciani R, Costi MP, Mangani S.

Molecules. 2019 Apr 7;24(7). pii: E1362. doi: 10.3390/molecules24071362.

6.

Structural Comparison of Enterococcus faecalis and Human Thymidylate Synthase Complexes with the Substrate dUMP and Its Analogue FdUMP Provides Hints about Enzyme Conformational Variabilities.

Pozzi C, Ferrari S, Luciani R, Tassone G, Costi MP, Mangani S.

Molecules. 2019 Mar 31;24(7). pii: E1257. doi: 10.3390/molecules24071257.

7.

Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections.

Linciano P, Pozzi C, Iacono LD, di Pisa F, Landi G, Bonucci A, Gul S, Kuzikov M, Ellinger B, Witt G, Santarem N, Baptista C, Franco C, Moraes CB, Müller W, Wittig U, Luciani R, Sesenna A, Quotadamo A, Ferrari S, Pöhner I, Cordeiro-da-Silva A, Mangani S, Costantino L, Costi MP.

J Med Chem. 2019 Apr 25;62(8):3989-4012. doi: 10.1021/acs.jmedchem.8b02021. Epub 2019 Apr 9.

PMID:
30908048
8.

Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform.

Moraes CB, Witt G, Kuzikov M, Ellinger B, Calogeropoulou T, Prousis KC, Mangani S, Di Pisa F, Landi G, Iacono LD, Pozzi C, Freitas-Junior LH, Dos Santos Pascoalino B, Bertolacini CP, Behrens B, Keminer O, Leu J, Wolf M, Reinshagen J, Cordeiro-da-Silva A, Santarem N, Venturelli A, Wrigley S, Karunakaran D, Kebede B, Pöhner I, Müller W, Panecka-Hofman J, Wade RC, Fenske M, Clos J, Alunda JM, Corral MJ, Uliassi E, Bolognesi ML, Linciano P, Quotadamo A, Ferrari S, Santucci M, Borsari C, Costi MP, Gul S.

SLAS Discov. 2019 Mar;24(3):346-361. doi: 10.1177/2472555218823171.

9.

SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model.

Leiris S, Coelho A, Castandet J, Bayet M, Lozano C, Bougnon J, Bousquet J, Everett M, Lemonnier M, Sprynski N, Zalacain M, Pallin TD, Cramp MC, Jennings N, Raphy G, Jones MW, Pattipati R, Shankar B, Sivasubrahmanyam R, Soodhagani AK, Juventhala RR, Pottabathini N, Pothukanuri S, Benvenuti M, Pozzi C, Mangani S, De Luca F, Cerboni G, Docquier JD, Davies DT.

ACS Infect Dis. 2019 Jan 11;5(1):131-140. doi: 10.1021/acsinfecdis.8b00246. Epub 2018 Nov 30.

10.

Probing the role of Arg97 in Heat shock protein 90 N-terminal domain from the parasite Leishmania braziliensis through site-directed mutagenesis on the human counterpart.

Tassone G, Mangani S, Botta M, Pozzi C.

Biochim Biophys Acta Proteins Proteom. 2018 Nov;1866(11):1190-1198. doi: 10.1016/j.bbapap.2018.09.005. Epub 2018 Sep 21.

PMID:
30248409
11.

The structure of the human glutaminyl cyclase-SEN177 complex indicates routes for developing new potent inhibitors as possible agents for the treatment of neurological disorders.

Pozzi C, Di Pisa F, Benvenuti M, Mangani S.

J Biol Inorg Chem. 2018 Dec;23(8):1219-1226. doi: 10.1007/s00775-018-1605-1. Epub 2018 Aug 21.

PMID:
30132075
12.

Atomic-Resolution Structure of a Class C β-Lactamase and Its Complex with Avibactam.

Pozzi C, Di Pisa F, De Luca F, Benvenuti M, Docquier JD, Mangani S.

ChemMedChem. 2018 Jul 18;13(14):1437-1446. doi: 10.1002/cmdc.201800213. Epub 2018 Jun 20.

PMID:
29786960
13.

Human Thymidylate Synthase Inhibitors Halting Ovarian Cancer Growth.

Ferrari S, Severi L, Pozzi C, Quotadamo A, Ponterini G, Losi L, Marverti G, Costi MP.

Vitam Horm. 2018;107:473-513. doi: 10.1016/bs.vh.2017.12.002. Epub 2018 Feb 12. Review.

PMID:
29544641
14.

In Silico Identification and In Vitro Evaluation of Natural Inhibitors of Leishmania major Pteridine Reductase I.

Herrmann FC, Sivakumar N, Jose J, Costi MP, Pozzi C, Schmidt TJ.

Molecules. 2017 Dec 6;22(12). pii: E2166. doi: 10.3390/molecules22122166.

15.

Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery.

Linciano P, Dawson A, Pöhner I, Costa DM, Sá MS, Cordeiro-da-Silva A, Luciani R, Gul S, Witt G, Ellinger B, Kuzikov M, Gribbon P, Reinshagen J, Wolf M, Behrens B, Hannaert V, Michels PAM, Nerini E, Pozzi C, di Pisa F, Landi G, Santarem N, Ferrari S, Saxena P, Lazzari S, Cannazza G, Freitas-Junior LH, Moraes CB, Pascoalino BS, Alcântara LM, Bertolacini CP, Fontana V, Wittig U, Müller W, Wade RC, Hunter WN, Mangani S, Costantino L, Costi MP.

ACS Omega. 2017 Sep 30;2(9):5666-5683. doi: 10.1021/acsomega.7b00473. Epub 2017 Sep 11.

16.

Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity.

Di Pisa F, Landi G, Dello Iacono L, Pozzi C, Borsari C, Ferrari S, Santucci M, Santarem N, Cordeiro-da-Silva A, Moraes CB, Alcantara LM, Fontana V, Freitas-Junior LH, Gul S, Kuzikov M, Behrens B, Pöhner I, Wade RC, Costi MP, Mangani S.

Molecules. 2017 Mar 8;22(3). pii: E426. doi: 10.3390/molecules22030426.

17.

Chemistry at the protein-mineral interface in L-ferritin assists the assembly of a functional (μ3-oxo)Tris[(μ2-peroxo)] triiron(III) cluster.

Pozzi C, Ciambellotti S, Bernacchioni C, Di Pisa F, Mangani S, Turano P.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2580-2585. doi: 10.1073/pnas.1614302114. Epub 2017 Feb 15.

18.

Ferroxidase Activity in Eukaryotic Ferritin is Controlled by Accessory-Iron-Binding Sites in the Catalytic Cavity.

Bernacchioni C, Pozzi C, Di Pisa F, Mangani S, Turano P.

Chemistry. 2016 Nov 2;22(45):16213-16219. doi: 10.1002/chem.201602842. Epub 2016 Sep 21.

PMID:
27650996
19.

Crystal Structure of the Pseudomonas aeruginosa BEL-1 Extended-Spectrum β-Lactamase and Its Complexes with Moxalactam and Imipenem.

Pozzi C, De Luca F, Benvenuti M, Poirel L, Nordmann P, Rossolini GM, Mangani S, Docquier JD.

Antimicrob Agents Chemother. 2016 Nov 21;60(12):7189-7199. Print 2016 Dec.

20.

X-ray crystal structures of Enterococcus faecalis thymidylate synthase with folate binding site inhibitors.

Catalano A, Luciani R, Carocci A, Cortesi D, Pozzi C, Borsari C, Ferrari S, Mangani S.

Eur J Med Chem. 2016 Nov 10;123:649-664. doi: 10.1016/j.ejmech.2016.07.066. Epub 2016 Jul 29.

PMID:
27517810

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