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Items: 1 to 20 of 91

1.

Decreased nuclear distribution nudE-like 1 enzyme activity in an animal model with dysfunctional disrupted-in-schizophrenia 1 signaling featuring aberrant neurodevelopment and amphetamine-supersensitivity.

Nani JV, Fonseca MC, Engi SA, Perillo MG, Dias CS, Gazarini ML, Korth C, Cruz FC, Hayashi MA.

J Psychopharmacol. 2020 Jan 9:269881119897562. doi: 10.1177/0269881119897562. [Epub ahead of print]

PMID:
31916893
2.

Disrupted-in-schizophrenia 1 functional polymorphisms and D2 /D3 receptor availability: A [11 C]-(+)-PHNO imaging study.

Dahoun T, Nour MM, Adams RA, Trossbach S, Lee SH, Patel H, Curtis C, Korth C, Howes OD.

Genes Brain Behav. 2019 Nov;18(8):e12596. doi: 10.1111/gbb.12596. Epub 2019 Jul 5.

PMID:
31264367
3.

Dysregulation of a specific immune-related network of genes biologically defines a subset of schizophrenia.

Trossbach SV, Hecher L, Schafflick D, Deenen R, Popa O, Lautwein T, Tschirner S, Köhrer K, Fehsel K, Papazova I, Malchow B, Hasan A, Winterer G, Schmitt A, Meyer Zu Hörste G, Falkai P, Korth C.

Transl Psychiatry. 2019 May 31;9(1):156. doi: 10.1038/s41398-019-0486-6.

4.

Disrupted-in-Schizophrenia 1 (DISC1) Overexpression and Juvenile Immune Activation Cause Sex-Specific Schizophrenia-Related Psychopathology in Rats.

Uzuneser TC, Speidel J, Kogias G, Wang AL, de Souza Silva MA, Huston JP, Zoicas I, von Hörsten S, Kornhuber J, Korth C, Müller CP.

Front Psychiatry. 2019 Apr 9;10:222. doi: 10.3389/fpsyt.2019.00222. eCollection 2019.

5.

Anxiogenic-like behavior and deficient attention/working memory in rats expressing the human DISC1 gene.

Wang AL, Chao OY, Yang YM, Trossbach SV, Müller CP, Korth C, Huston JP, de Souza Silva MA.

Pharmacol Biochem Behav. 2019 Apr;179:73-79. doi: 10.1016/j.pbb.2019.02.005. Epub 2019 Feb 16.

PMID:
30779934
6.

Disrupted-in-schizophrenia 1 overexpression disrupts hippocampal coding and oscillatory synchronization.

Kaefer K, Malagon-Vina H, Dickerson DD, O'Neill J, Trossbach SV, Korth C, Csicsvari J.

Hippocampus. 2019 Sep;29(9):802-816. doi: 10.1002/hipo.23076. Epub 2019 Feb 5.

7.

Proteomic Studies Reveal Disrupted in Schizophrenia 1 as a Player in Both Neurodevelopment and Synaptic Function.

Ramos A, Rodríguez-Seoane C, Rosa I, Gorroño-Etxebarria I, Alonso J, Veiga S, Korth C, Kypta RM, García Á, Requena JR.

Int J Mol Sci. 2018 Dec 29;20(1). pii: E119. doi: 10.3390/ijms20010119.

8.

Protein misassembly and aggregation as potential convergence points for non-genetic causes of chronic mental illness.

Bradshaw NJ, Korth C.

Mol Psychiatry. 2019 Jul;24(7):936-951. doi: 10.1038/s41380-018-0133-2. Epub 2018 Aug 8. Review.

PMID:
30089789
9.

The effect of the DISC1 Ser704Cys polymorphism on striatal dopamine synthesis capacity: an [18F]-DOPA PET study.

Dahoun T, Pardiñas AF, Veronese M, Bloomfield MAP, Jauhar S, Bonoldi I, Froudist-Walsh S, Nosarti C, Korth C, Hennah W, Walters J, Prata D, Howes OD.

Hum Mol Genet. 2018 Oct 15;27(20):3498-3506. doi: 10.1093/hmg/ddy242.

10.

Aβ dimers induce behavioral and neurochemical deficits of relevance to early Alzheimer's disease.

Abdel-Hafiz L, Müller-Schiffmann A, Korth C, Fazari B, Chao OY, Nikolaus S, Schäble S, Herring A, Keyvani K, Lamounier-Zepter V, Huston JP, de Souza Silva MA.

Neurobiol Aging. 2018 Sep;69:1-9. doi: 10.1016/j.neurobiolaging.2018.04.005. Epub 2018 Apr 17.

PMID:
29803148
11.

Quantitative Proteomics of Synaptosomal Fractions in a Rat Overexpressing Human DISC1 Gene Indicates Profound Synaptic Dysregulation in the Dorsal Striatum.

Sialana FJ, Wang AL, Fazari B, Kristofova M, Smidak R, Trossbach SV, Korth C, Huston JP, de Souza Silva MA, Lubec G.

Front Mol Neurosci. 2018 Feb 6;11:26. doi: 10.3389/fnmol.2018.00026. eCollection 2018.

12.

Biophysical insights from a single chain camelid antibody directed against the Disrupted-in-Schizophrenia 1 protein.

Yerabham ASK, Müller-Schiffmann A, Ziehm T, Stadler A, Köber S, Indurkhya X, Marreiros R, Trossbach SV, Bradshaw NJ, Prikulis I, Willbold D, Weiergräber OH, Korth C.

PLoS One. 2018 Jan 11;13(1):e0191162. doi: 10.1371/journal.pone.0191162. eCollection 2018.

13.

Intra-nasal dopamine alleviates cognitive deficits in tgDISC1 rats which overexpress the human DISC1 gene.

Wang AL, Fazari B, Chao OY, Nikolaus S, Trossbach SV, Korth C, Sialana FJ, Lubec G, Huston JP, Mattern C, de Souza Silva MA.

Neurobiol Learn Mem. 2017 Dec;146:12-20. doi: 10.1016/j.nlm.2017.10.015. Epub 2017 Oct 28.

PMID:
29107702
14.

Loss of Reelin protects mice against arterial thrombosis by impairing integrin activation and thrombus formation under high shear conditions.

Gowert NS, Krüger I, Klier M, Donner L, Kipkeew F, Gliem M, Bradshaw NJ, Lutz D, Köber S, Langer H, Jander S, Jurk K, Frotscher M, Korth C, Bock HH, Elvers M.

Cell Signal. 2017 Dec;40:210-221. doi: 10.1016/j.cellsig.2017.09.016. Epub 2017 Sep 21.

PMID:
28943410
15.

An unpredicted aggregation-critical region of the actin-polymerizing protein TRIOBP-1/Tara, determined by elucidation of its domain structure.

Bradshaw NJ, Yerabham ASK, Marreiros R, Zhang T, Nagel-Steger L, Korth C.

J Biol Chem. 2017 Jun 9;292(23):9583-9598. doi: 10.1074/jbc.M116.767939. Epub 2017 Apr 24.

16.

Disrupted in Schizophrenia 1 regulates the processing of reelin in the perinatal cortex.

Bradshaw NJ, Trossbach SV, Köber S, Walter S, Prikulis I, Weggen S, Korth C.

Schizophr Res. 2017 Apr 19. pii: S0920-9964(17)30200-1. doi: 10.1016/j.schres.2017.04.012. [Epub ahead of print]

PMID:
28433501
17.

Transfer of disrupted-in-schizophrenia 1 aggregates between neuronal-like cells occurs in tunnelling nanotubes and is promoted by dopamine.

Zhu S, Abounit S, Korth C, Zurzolo C.

Open Biol. 2017 Mar;7(3). pii: 160328. doi: 10.1098/rsob.160328.

18.

A structural organization for the Disrupted in Schizophrenia 1 protein, identified by high-throughput screening, reveals distinctly folded regions, which are bisected by mental illness-related mutations.

Yerabham ASK, Mas PJ, Decker C, Soares DC, Weiergräber OH, Nagel-Steger L, Willbold D, Hart DJ, Bradshaw NJ, Korth C.

J Biol Chem. 2017 Apr 21;292(16):6468-6477. doi: 10.1074/jbc.M116.773903. Epub 2017 Mar 1.

19.

Simultaneous effects on parvalbumin-positive interneuron and dopaminergic system development in a transgenic rat model for sporadic schizophrenia.

Hamburg H, Trossbach SV, Bader V, Chwiesko C, Kipar A, Sauvage M, Crum WR, Vernon AC, Bidmon HJ, Korth C.

Sci Rep. 2016 Oct 10;6:34946. doi: 10.1038/srep34946.

20.

Revisiting rodent models: Octodon degus as Alzheimer's disease model?

Steffen J, Krohn M, Paarmann K, Schwitlick C, Brüning T, Marreiros R, Müller-Schiffmann A, Korth C, Braun K, Pahnke J.

Acta Neuropathol Commun. 2016 Aug 26;4(1):91. doi: 10.1186/s40478-016-0363-y.

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