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The MicroRNA miR-155 Is Essential in Fibrosis.

Eissa MG, Artlett CM.

Noncoding RNA. 2019 Mar 12;5(1). pii: E23. doi: 10.3390/ncrna5010023. Review.


NADPH oxidase-mediated induction of reactive oxygen species and extracellular matrix deposition by insulin-like growth factor binding protein-5.

Yasuoka H, Garrett SM, Nguyen XX, Artlett CM, Feghali-Bostwick CA.

Am J Physiol Lung Cell Mol Physiol. 2019 Apr 1;316(4):L644-L655. doi: 10.1152/ajplung.00106.2018. Epub 2019 Feb 27.


Preclinical study of the long-range safety and anti-inflammatory effects of high-dose oral meglumine.

Manley K, Bravo-Nuevo A, Minton AR, Sedano S, Marcy A, Reichman M, Tobia A, Artlett CM, Gilmour SK, Laury-Kleintop LD, Prendergast GC.

J Cell Biochem. 2019 Feb 27. doi: 10.1002/jcb.28492. [Epub ahead of print]


The IL-1 family of cytokines. Do they have a role in scleroderma fibrosis?

Artlett CM.

Immunol Lett. 2018 Mar;195:30-37. doi: 10.1016/j.imlet.2017.11.012. Epub 2017 Dec 5. Review.


Mir-155 is overexpressed in systemic sclerosis fibroblasts and is required for NLRP3 inflammasome-mediated collagen synthesis during fibrosis.

Artlett CM, Sassi-Gaha S, Hope JL, Feghali-Bostwick CA, Katsikis PD.

Arthritis Res Ther. 2017 Jun 17;19(1):144. doi: 10.1186/s13075-017-1331-z.


Markers of immune-mediated inflammation in the brains of young adults and adolescents with type 1 diabetes and fatal diabetic ketoacidosis. Is there a difference?

Hoffman WH, Artlett CM, Boodhoo D, Gilliland MGF, Ortiz L, Mulder D, Tjan DHT, Martin A, Tatomir A, Rus H.

Exp Mol Pathol. 2017 Jun;102(3):505-514. doi: 10.1016/j.yexmp.2017.05.013. Epub 2017 May 19.


Transforming growth factor β1 (TGFβ1)-induced CD44V6-NOX4 signaling in pathogenesis of idiopathic pulmonary fibrosis.

Ghatak S, Hascall VC, Markwald RR, Feghali-Bostwick C, Artlett CM, Gooz M, Bogatkevich GS, Atanelishvili I, Silver RM, Wood J, Thannickal VJ, Misra S.

J Biol Chem. 2017 Jun 23;292(25):10490-10519. doi: 10.1074/jbc.M116.752469. Epub 2017 Apr 7.


Identification of Optimal Mouse Models of Systemic Sclerosis by Interspecies Comparative Genomics.

Sargent JL, Li Z, Aliprantis AO, Greenblatt M, Lemaire R, Wu MH, Wei J, Taroni J, Harris A, Long KB, Burgwin C, Artlett CM, Blankenhorn EP, Lafyatis R, Varga J, Clark SH, Whitfield ML.

Arthritis Rheumatol. 2016 Aug;68(8):2003-15. doi: 10.1002/art.39658.


Chimeric cells of maternal origin do not appear to be pathogenic in the juvenile idiopathic inflammatory myopathies or muscular dystrophy.

Artlett CM, Sassi-Gaha S, Ramos RC, Miller FW, Rider LG.

Arthritis Res Ther. 2015 Sep 4;17:238. doi: 10.1186/s13075-015-0732-0.


The Tsk2/+ mouse fibrotic phenotype is due to a gain-of-function mutation in the PIIINP segment of the Col3a1 gene.

Long KB, Li Z, Burgwin CM, Choe SG, Martyanov V, Sassi-Gaha S, Earl JP, Eutsey RA, Ahmed A, Ehrlich GD, Artlett CM, Whitfield ML, Blankenhorn EP.

J Invest Dermatol. 2015 Mar;135(3):718-27. doi: 10.1038/jid.2014.455. Epub 2014 Oct 20.


Molecular activation of the NLRP3 Inflammasome in fibrosis: common threads linking divergent fibrogenic diseases.

Artlett CM, Thacker JD.

Antioxid Redox Signal. 2015 May 1;22(13):1162-75. doi: 10.1089/ars.2014.6148. Epub 2014 Dec 9. Review.


Tight Skin 2 Mice Exhibit Delayed Wound Healing Caused by Increased Elastic Fibers in Fibrotic Skin.

Long KB, Burgwin CM, Huneke R, Artlett CM, Blankenhorn EP.

Adv Wound Care (New Rochelle). 2014 Sep 1;3(9):573-581.


Animal models of systemic sclerosis: their utility and limitations.

Artlett CM.

Open Access Rheumatol. 2014 Jul 1;6:65-81. eCollection 2014. Review.


Tight skin 2 mice exhibit a novel time line of events leading to increased extracellular matrix deposition and dermal fibrosis.

Long KB, Artlett CM, Blankenhorn EP.

Matrix Biol. 2014 Sep;38:91-100. doi: 10.1016/j.matbio.2014.05.002. Epub 2014 May 10.


Targeting the unfolded protein response, XBP1, and the NLRP3 inflammasome in fibrosis and cancer.

Overley-Adamson B, Artlett CM, Stephens C, Sassi-Gaha S, Weis RD, Thacker JD.

Cancer Biol Ther. 2014 Apr;15(4):452-62. doi: 10.4161/cbt.27820. Epub 2014 Feb 4.


Two α-dicarbonyls downregulate migration, invasion, and adhesion of liver cancer cells in a p53-dependent manner.

Loarca L, Sassi-Gaha S, Artlett CM.

Dig Liver Dis. 2013 Nov;45(11):938-46. doi: 10.1016/j.dld.2013.05.005. Epub 2013 Sep 23.


Inflammasomes in wound healing and fibrosis.

Artlett CM.

J Pathol. 2013 Jan;229(2):157-67. doi: 10.1002/path.4116. Review.


The Role of the NLRP3 Inflammasome in Fibrosis.

Artlett CM.

Open Rheumatol J. 2012;6:80-6. doi: 10.2174/1874312901206010080. Epub 2012 Jun 15.


NLRP3 inflammasome is a target for development of broad-spectrum anti-infective drugs.

Thacker JD, Balin BJ, Appelt DM, Sassi-Gaha S, Purohit M, Rest RF, Artlett CM.

Antimicrob Agents Chemother. 2012 Apr;56(4):1921-30. doi: 10.1128/AAC.06372-11. Epub 2012 Jan 30.


The inflammasome activating caspase 1 mediates fibrosis and myofibroblast differentiation in systemic sclerosis.

Artlett CM, Sassi-Gaha S, Rieger JL, Boesteanu AC, Feghali-Bostwick CA, Katsikis PD.

Arthritis Rheum. 2011 Nov;63(11):3563-74. doi: 10.1002/art.30568.

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