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Items: 1 to 20 of 38

1.

Chronic In Vivo Effects of Repeated Exposure to Low Oral Doses of Tetrodotoxin: Preliminary Evidence of Nephrotoxicity and Cardiotoxicity.

Boente-Juncal A, Vale C, Cifuentes M, Otero P, Camiña M, Rodriguez-Vieytes M, Botana LM.

Toxins (Basel). 2019 Feb 6;11(2). pii: E96. doi: 10.3390/toxins11020096.

2.

Structure Elucidation and Biological Evaluation of Maitotoxin-3, a Homologue of Gambierone, from Gambierdiscus belizeanus.

Boente-Juncal A, Álvarez M, Antelo Á, Rodríguez I, Calabro K, Vale C, Thomas OP, Botana LM.

Toxins (Basel). 2019 Feb 1;11(2). pii: E79. doi: 10.3390/toxins11020079.

3.

Transcriptomic Analysis of Ciguatoxin-Induced Changes in Gene Expression in Primary Cultures of Mice Cortical Neurons.

Rubiolo JA, Vale C, Boente-Juncal A, Hirama M, Yamashita S, Camiña M, Vieytes MR, Botana LM.

Toxins (Basel). 2018 May 10;10(5). pii: E192. doi: 10.3390/toxins10050192.

4.

Synergistic Effect of Transient Receptor Potential Antagonist and Amiloride against Maitotoxin Induced Calcium Increase and Cytotoxicity in Human Neuronal Stem Cells.

Boente-Juncal A, Vale C, Alfonso A, Botana LM.

ACS Chem Neurosci. 2018 Nov 21;9(11):2667-2678. doi: 10.1021/acschemneuro.8b00128. Epub 2018 May 16.

PMID:
29733572
5.

In Vitro Effects of Chronic Spirolide Treatment on Human Neuronal Stem Cell Differentiation and Cholinergic System Development.

Boente-Juncal A, Méndez AG, Vale C, Vieytes MR, Botana LM.

ACS Chem Neurosci. 2018 Jun 20;9(6):1441-1452. doi: 10.1021/acschemneuro.8b00036. Epub 2018 Mar 14.

PMID:
29518322
6.

The Marine Guanidine Alkaloid Crambescidin 816 Induces Calcium Influx and Cytotoxicity in Primary Cultures of Cortical Neurons through Glutamate Receptors.

Mendez AG, Juncal AB, Silva SBL, Thomas OP, Martín Vázquez V, Alfonso A, Vieytes MR, Vale C, Botana LM.

ACS Chem Neurosci. 2017 Jul 19;8(7):1609-1617. doi: 10.1021/acschemneuro.7b00096. Epub 2017 Apr 24.

PMID:
28375602
7.

Chronic ciguatoxin treatment induces synaptic scaling through voltage gated sodium channels in cortical neurons.

Martín V, Vale C, Rubiolo JA, Roel M, Hirama M, Yamashita S, Vieytes MR, Botana LM.

Chem Res Toxicol. 2015 Jun 15;28(6):1109-19. doi: 10.1021/tx500506q. Epub 2015 May 19.

PMID:
25945544
8.

Synthetic ciguatoxin CTX 3C induces a rapid imbalance in neuronal excitability.

Martín V, Vale C, Hirama M, Yamashita S, Rubiolo JA, Vieytes MR, Botana LM.

Chem Res Toxicol. 2015 Jun 15;28(6):1095-108. doi: 10.1021/tx500503d. Epub 2015 May 19.

PMID:
25945403
9.

Autumnalamide, a prenylated cyclic peptide from the cyanobacterium Phormidium autumnale, acts on SH-SY5Y cells at the mitochondrial level.

Audoin C, Sánchez JA, Genta-Jouve G, Alfonso A, Rios L, Vale C, Thomas OP, Botana LM.

J Nat Prod. 2014 Oct 24;77(10):2196-205. doi: 10.1021/np500374a. Epub 2014 Sep 29.

PMID:
25265024
10.

Differential effects of ciguatoxin and maitotoxin in primary cultures of cortical neurons.

Martin V, Vale C, Antelo A, Hirama M, Yamashita S, Vieytes MR, Botana LM.

Chem Res Toxicol. 2014 Aug 18;27(8):1387-400. doi: 10.1021/tx5000969. Epub 2014 Jul 15.

PMID:
24999537
11.

Translocation of PKC by yessotoxin in an in vitro model of Alzheimer's disease with improvement of tau and β-amyloid pathology.

Alonso E, Vale C, Vieytes MR, Botana LM.

ACS Chem Neurosci. 2013 Jul 17;4(7):1062-70. doi: 10.1021/cn400018y. Epub 2013 Apr 8.

12.

Differential effects of crambescins and crambescidin 816 in voltage-gated sodium, potassium and calcium channels in neurons.

Martín V, Vale C, Bondu S, Thomas OP, Vieytes MR, Botana LM.

Chem Res Toxicol. 2013 Jan 18;26(1):169-78. doi: 10.1021/tx3004483. Epub 2013 Jan 9.

PMID:
23270282
13.

Benefit of 13-desmethyl spirolide C treatment in triple transgenic mouse model of Alzheimer disease: beta-amyloid and neuronal markers improvement.

Alonso E, Otero P, Vale C, Alfonso A, Antelo A, Giménez-Llort L, Chabaud L, Guillou C, Botana LM.

Curr Alzheimer Res. 2013 Mar;10(3):279-89.

PMID:
23036025
14.

Effect of gambierol and its tetracyclic and heptacyclic analogues in cultured cerebellar neurons: a structure-activity relationships study.

Pérez S, Vale C, Alonso E, Fuwa H, Sasaki M, Konno Y, Goto T, Suga Y, Vieytes MR, Botana LM.

Chem Res Toxicol. 2012 Sep 17;25(9):1929-37. doi: 10.1021/tx300242m. Epub 2012 Aug 29.

PMID:
22894724
15.

Design and synthesis of skeletal analogues of gambierol: attenuation of amyloid-β and tau pathology with voltage-gated potassium channel and N-methyl-D-aspartate receptor implications.

Alonso E, Fuwa H, Vale C, Suga Y, Goto T, Konno Y, Sasaki M, LaFerla FM, Vieytes MR, Giménez-Llort L, Botana LM.

J Am Chem Soc. 2012 May 2;134(17):7467-79. doi: 10.1021/ja300565t. Epub 2012 Apr 18.

PMID:
22475455
16.

13-Desmethyl spirolide-C is neuroprotective and reduces intracellular Aβ and hyperphosphorylated tau in vitro.

Alonso E, Vale C, Vieytes MR, Laferla FM, Giménez-Llort L, Botana LM.

Neurochem Int. 2011 Dec;59(7):1056-65. doi: 10.1016/j.neuint.2011.08.013. Epub 2011 Aug 30.

PMID:
21907746
17.

The cholinergic antagonist gymnodimine improves Aβ and tau neuropathology in an in vitro model of Alzheimer disease.

Alonso E, Vale C, Vieytes MR, Laferla FM, Giménez-Llort L, Botana LM.

Cell Physiol Biochem. 2011;27(6):783-94. doi: 10.1159/000330086. Epub 2011 Jun 17.

18.

Determination of toxicity equivalent factors for paralytic shellfish toxins by electrophysiological measurements in cultured neurons.

Perez S, Vale C, Botana AM, Alonso E, Vieytes MR, Botana LM.

Chem Res Toxicol. 2011 Jul 18;24(7):1153-7. doi: 10.1021/tx200173d. Epub 2011 Jun 8.

PMID:
21619049
19.

A comparative study of the effect of ciguatoxins on voltage-dependent Na+ and K+ channels in cerebellar neurons.

Pérez S, Vale C, Alonso E, Alfonso C, Rodríguez P, Otero P, Alfonso A, Vale P, Hirama M, Vieytes MR, Botana LM.

Chem Res Toxicol. 2011 Apr 18;24(4):587-96. doi: 10.1021/tx200043j. Epub 2011 Mar 21.

PMID:
21351754
20.

First toxin profile of ciguateric fish in Madeira Arquipelago (Europe).

Otero P, Pérez S, Alfonso A, Vale C, Rodríguez P, Gouveia NN, Gouveia N, Delgado J, Vale P, Hirama M, Ishihara Y, Molgó J, Botana LM.

Anal Chem. 2010 Jul 15;82(14):6032-9. doi: 10.1021/ac100516q.

PMID:
20557036

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