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Items: 1 to 20 of 131

1.

Synthesis of polyfluoroalkyl sp2-iminosugar glycolipids and evaluation of their immunomodulatory properties towards anti-tumor, anti-leishmanial and anti-inflammatory therapies.

Sánchez-Fernández EM, García-Moreno MI, Arroba AI, Aguilar-Diosdado M, Padrón JM, García-Hernández R, Gamarro F, Fustero S, Sánchez-Aparicio JE, Masgrau L, García Fernández JM, Ortiz Mellet C.

Eur J Med Chem. 2019 Aug 8;182:111604. doi: 10.1016/j.ejmech.2019.111604. [Epub ahead of print]

PMID:
31425910
2.

Thiol-ene "Click" Synthesis and Pharmacological Evaluation of C-Glycoside sp2-Iminosugar Glycolipids.

Sánchez-Fernández EM, García-Moreno MI, García-Hernández R, Padrón JM, García Fernández JM, Gamarro F, Ortiz Mellet C.

Molecules. 2019 Aug 8;24(16). pii: E2882. doi: 10.3390/molecules24162882.

3.

Novel Therapies for Orphan Diseases.

García Fernández JM, Ortiz Mellet C.

ACS Med Chem Lett. 2019 Jun 18;10(7):1020-1023. doi: 10.1021/acsmedchemlett.9b00242. eCollection 2019 Jul 11.

PMID:
31312401
4.

Trehalose-based Siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties.

Carbajo-Gordillo AI, Rodríguez-Lavado J, Jiménez Blanco JL, Benito JM, Di Giorgio C, Vélaz I, Tros de Ilarduya C, Ortiz Mellet C, García Fernández JM.

Chem Commun (Camb). 2019 Jul 11;55(57):8227-8230. doi: 10.1039/c9cc04489b.

PMID:
31268107
5.

Pharmacological Chaperones for the Treatment of α-Mannosidosis.

Rísquez-Cuadro R, Matsumoto R, Ortega-Caballero F, Nanba E, Higaki K, García Fernández JM, Ortiz Mellet C.

J Med Chem. 2019 Jun 27;62(12):5832-5843. doi: 10.1021/acs.jmedchem.9b00153. Epub 2019 May 2.

PMID:
31017416
6.

Dynamic Control of the Self-Assembling Properties of Cyclodextrins by the Interplay of Aromatic and Host-Guest Interactions.

Neva T, Carmona T, Benito JM, Przybylski C, Ortiz Mellet C, Mendicuti F, García Fernández JM.

Front Chem. 2019 Feb 25;7:72. doi: 10.3389/fchem.2019.00072. eCollection 2019.

7.

sp2-Iminosugar glycolipids as inhibitors of lipopolysaccharide-mediated human dendritic cell activation in vitro and of acute inflammation in mice in vivo.

Schaeffer E, Sánchez-Fernández EM, Gonçalves-Pereira R, Flacher V, Lamon D, Duval M, Fauny JD, García Fernández JM, Mueller CG, Ortiz Mellet C.

Eur J Med Chem. 2019 May 1;169:111-120. doi: 10.1016/j.ejmech.2019.02.078. Epub 2019 Mar 5.

PMID:
30870792
8.

Catalyst-Free Synthesis of Alkylpolyglycosides Induced by High-Frequency Ultrasound.

Amaniampong PN, Clément JL, Gigmes D, Ortiz Mellet C, García Fernández JM, Blériot Y, Chatel G, De Oliveira Vigier K, Jérôme F.

ChemSusChem. 2018 Aug 22;11(16):2673-2676. doi: 10.1002/cssc.201801137. Epub 2018 Jul 16.

PMID:
29938918
9.

Xylylene Clips for the Topology-Guided Control of the Inclusion and Self-Assembling Properties of Cyclodextrins.

Neva T, Carmona T, Benito JM, Przybylski C, Ortiz Mellet C, Mendicuti F, García Fernández JM.

J Org Chem. 2018 May 18;83(10):5588-5597. doi: 10.1021/acs.joc.8b00602. Epub 2018 May 2.

PMID:
29683327
10.

Probing the Inhibitor versus Chaperone Properties of sp²-Iminosugars towards Human β-Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease.

Mena-Barragán T, García-Moreno MI, Sevšek A, Okazaki T, Nanba E, Higaki K, Martin NI, Pieters RJ, Fernández JMG, Mellet CO.

Molecules. 2018 Apr 17;23(4). pii: E927. doi: 10.3390/molecules23040927.

11.

Plasmid-Templated Control of DNA-Cyclodextrin Nanoparticle Morphology through Molecular Vector Design for Effective Gene Delivery.

Gallego-Yerga L, Benito JM, Blanco-Fernández L, Martínez-Negro M, Vélaz I, Aicart E, Junquera E, Ortiz Mellet C, Tros de Ilarduya C, García Fernández JM.

Chemistry. 2018 Mar 12;24(15):3825-3835. doi: 10.1002/chem.201705723. Epub 2018 Feb 19.

PMID:
29341305
12.

Revealing cooperative binding of polycationic cyclodextrins with DNA oligomers by capillary electrophoresis coupled to mass spectrometry.

Przybylski C, Benito JM, Bonnet V, Mellet CO, García Fernández JM.

Anal Chim Acta. 2018 Mar 9;1002:70-81. doi: 10.1016/j.aca.2017.11.034. Epub 2017 Nov 22.

PMID:
29306415
13.

Giant Glycosidase Inhibitors: First- and Second-Generation Fullerodendrimers with a Dense Iminosugar Shell.

Nierengarten JF, Schneider JP, Trinh TMN, Joosten A, Holler M, Lepage ML, Bodlenner A, García-Moreno MI, Ortiz Mellet C, Compain P.

Chemistry. 2018 Feb 16;24(10):2483-2492. doi: 10.1002/chem.201705600. Epub 2018 Jan 25.

PMID:
29281149
14.

The sp2-iminosugar glycolipid 1-dodecylsulfonyl-5N,6O-oxomethylidenenojirimycin (DSO2-ONJ) as selective anti-inflammatory agent by modulation of hemeoxygenase-1 in Bv.2 microglial cells and retinal explants.

Alcalde-Estévez E, Arroba AI, Sánchez-Fernández EM, Mellet CO, García Fernández JM, Masgrau L, Valverde ÁM.

Food Chem Toxicol. 2018 Jan;111:454-466. doi: 10.1016/j.fct.2017.11.050. Epub 2017 Nov 27.

PMID:
29191728
15.

Development of polycationic amphiphilic cyclodextrin nanoparticles for anticancer drug delivery.

Varan G, Benito JM, Mellet CO, Bilensoy E.

Beilstein J Nanotechnol. 2017 Jul 13;8:1457-1468. doi: 10.3762/bjnano.8.145. eCollection 2017.

16.

Molecular determinants for cyclo-oligosaccharide-based nanoparticle-mediated effective siRNA transfection.

Manzanares D, Araya-Durán I, Gallego-Yerga L, Játiva P, Márquez-Miranda V, Canan J, Jiménez Blanco JL, Mellet CO, González-Nilo FD, García Fernández JM, Ceña V.

Nanomedicine (Lond). 2017 Jul;12(13):1607-1621. doi: 10.2217/nnm-2017-0123. Epub 2017 Jun 16.

PMID:
28621615
17.

Carbon Dioxide as a Traceless Caramelization Promotor: Preparation of Prebiotic Difructose Dianhydrides (DFAs)-Enriched Caramels from d-Fructose.

Audemar M, Atencio-Genes L, Ortiz Mellet C, Jérôme F, Garcia Fernandez JM, De Oliveira Vigier K.

J Agric Food Chem. 2017 Aug 2;65(30):6093-6099. doi: 10.1021/acs.jafc.7b01601. Epub 2017 Jun 11.

PMID:
28557424
18.

Docetaxel-Loaded Nanoparticles Assembled from β-Cyclodextrin/Calixarene Giant Surfactants: Physicochemical Properties and Cytotoxic Effect in Prostate Cancer and Glioblastoma Cells.

Gallego-Yerga L, Posadas I, de la Torre C, Ruiz-Almansa J, Sansone F, Ortiz Mellet C, Casnati A, García Fernández JM, Ceña V.

Front Pharmacol. 2017 May 8;8:249. doi: 10.3389/fphar.2017.00249. eCollection 2017.

19.

The Impact of Heteromultivalency in Lectin Recognition and Glycosidase Inhibition: An Integrated Mechanistic Study.

García-Moreno MI, Ortega-Caballero F, Rísquez-Cuadro R, Ortiz Mellet C, García Fernández JM.

Chemistry. 2017 May 5;23(26):6295-6304. doi: 10.1002/chem.201700470. Epub 2017 Apr 5.

PMID:
28240441
20.

Fluorinated Chaperone-β-Cyclodextrin Formulations for β-Glucocerebrosidase Activity Enhancement in Neuronopathic Gaucher Disease.

García-Moreno MI, de la Mata M, Sánchez-Fernández EM, Benito JM, Díaz-Quintana A, Fustero S, Nanba E, Higaki K, Sánchez-Alcázar JA, García Fernández JM, Ortiz Mellet C.

J Med Chem. 2017 Mar 9;60(5):1829-1842. doi: 10.1021/acs.jmedchem.6b01550. Epub 2017 Feb 22.

PMID:
28171725

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