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Cancers (Basel). 2019 Mar 7;11(3). pii: E324. doi: 10.3390/cancers11030324.

Expanding the Role of the Histone Lysine-Specific Demethylase LSD1 in Cancer.

Author information

1
Department of Biology, University of Naples 'Federico II', 80126 Naples, Italy. majello@unina.it.
2
Department of Molecular Medicine and Medical Biotechnologies, University of Naples, 'Federico II', 80131 Naples, Italy. francesca.gorini@unina.it.
3
Department of Biology, University of Naples 'Federico II', 80126 Naples, Italy. carmendaniela.sacca@unina.it.
4
Department of Molecular Medicine and Medical Biotechnologies, University of Naples, 'Federico II', 80131 Naples, Italy. stamente@unina.it.

Abstract

Studies of alterations in histone methylation in cancer have led to the identification of histone methyltransferases and demethylases as novel targets for therapy. Lysine-specific demethylase 1 (LSD1, also known as KDM1A), demethylates H3K4me1/2, or H3K9me1/2 in a context-dependent manner. In addition to the well-studied role of LSD1 in the epigenetic regulation of histone methylation changes, LSD1 regulates the methylation dynamic of several non-histone proteins and participates in the assembly of different long noncoding RNA (lncRNA_ complexes. LSD1 is highly expressed in various cancers, playing a pivotal role in different cancer-related processes. Here, we summarized recent findings on the role of LSD1 in the regulation of different biological processes in cancer cells through dynamic methylation of non-histone proteins and physical association with dedicated lncRNA.

KEYWORDS:

LSD1; cancer; epigenetics; histone demethylase; lncRNAs

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