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Items: 1 to 20 of 59


Rescue of Noradrenergic System as a Novel Pharmacological Strategy in the Treatment of Chronic Pain: Focus on Microglia Activation.

Caraci F, Merlo S, Drago F, Caruso G, Parenti C, Sortino MA.

Front Pharmacol. 2019 Sep 12;10:1024. doi: 10.3389/fphar.2019.01024. eCollection 2019. Review.


Progress in the development of more effective and safer analgesics for pain management.

Turnaturi R, Chiechio S, Salerno L, Rescifina A, Pittalà V, Cantarella G, Tomarchio E, Parenti C, Pasquinucci L.

Eur J Med Chem. 2019 Dec 1;183:111701. doi: 10.1016/j.ejmech.2019.111701. Epub 2019 Sep 16. Review.


Preclinical evidence of enhanced analgesic activity of duloxetine complexed with succinyl-β-cyclodextrin: A comparative study with cyclodextrin complexes.

Seggio M, Contino A, Maccarrone G, Parenti C, Merlo S, Pappalardo G, Giuffrida A, Chiechio S.

Int J Pharm. 2019 Jul 20;566:391-399. doi: 10.1016/j.ijpharm.2019.05.077. Epub 2019 May 31.


Synthesis, in vitro and in vivo characterization of new benzoxazole and benzothiazole-based sigma receptor ligands.

Romeo G, Prezzavento O, Intagliata S, Pittalà V, Modica MN, Marrazzo A, Turnaturi R, Parenti C, Chiechio S, Arena E, Campisi A, Sposito G, Salerno L.

Eur J Med Chem. 2019 Jul 15;174:226-235. doi: 10.1016/j.ejmech.2019.04.056. Epub 2019 Apr 21.


Simultaneous Activation of Mu and Delta Opioid Receptors Reduces Allodynia and Astrocytic Connexin 43 in an Animal Model of Neuropathic Pain.

Vicario N, Pasquinucci L, Spitale FM, Chiechio S, Turnaturi R, Caraci F, Tibullo D, Avola R, Gulino R, Parenti R, Parenti C.

Mol Neurobiol. 2019 Nov;56(11):7338-7354. doi: 10.1007/s12035-019-1607-1. Epub 2019 Apr 28.


Neuroprotective effects of Rosmarinus officinalis L. extract in oxygen glucose deprivation (OGD)-injured human neural-like cells.

Zappalà A, Vicario N, Calabrese G, Turnaturi R, Pasquinucci L, Montenegro L, Spadaro A, Parenti R, Parenti C.

Nat Prod Res. 2019 Apr 2:1-7. doi: 10.1080/14786419.2019.1587428. [Epub ahead of print]


(2S)-N-2-methoxy-2-phenylethyl-6,7-benzomorphan compound (2S-LP2): Discovery of a biased mu/delta opioid receptor agonist.

Pasquinucci L, Turnaturi R, Calò G, Pappalardo F, Ferrari F, Russo G, Arena E, Montenegro L, Chiechio S, Prezzavento O, Parenti C.

Eur J Med Chem. 2019 Apr 15;168:189-198. doi: 10.1016/j.ejmech.2019.02.043. Epub 2019 Feb 18.


Simultaneous targeting of MOR/DOR: A useful strategy for inflammatory pain modulation.

Pasquinucci L, Turnaturi R, Montenegro L, Caraci F, Chiechio S, Parenti C.

Eur J Pharmacol. 2019 Mar 15;847:97-102. doi: 10.1016/j.ejphar.2019.01.031. Epub 2019 Jan 25.


Tumor necrosis factor-related apoptosis-inducing ligand reduces the expression of the neuroprotective Na+ /Ca2+ exchanger isoform NCX3 in human neuroblastoma SH-SY5Y cells.

Di Benedetto G, Valerio O, Lariccia V, Burgaletto C, Lempereur L, Parenti C, Zanghì GN, Matteucci A, Amoroso S, Bernardini R, Cantarella G.

FEBS J. 2019 Feb;286(4):737-749. doi: 10.1111/febs.14732. Epub 2019 Jan 8.


Benzomorphan skeleton, a versatile scaffold for different targets: A comprehensive review.

Turnaturi R, Montenegro L, Marrazzo A, Parenti R, Pasquinucci L, Parenti C.

Eur J Med Chem. 2018 Jul 15;155:492-502. doi: 10.1016/j.ejmech.2018.06.017. Epub 2018 Jun 7. Review.


Synthesis and Structure-Activity Relationships of (-)-cis-N-Normetazocine-Based LP1 Derivatives.

Pasquinucci L, Parenti C, Amata E, Georgoussi Z, Pallaki P, Camarda V, Calò G, Arena E, Montenegro L, Turnaturi R.

Pharmaceuticals (Basel). 2018 May 5;11(2). pii: E40. doi: 10.3390/ph11020040.


Synthesis and Structure-Activity Relationships of LP1 Derivatives: N-Methyl-N-phenylethylamino Analogues as Novel MOR Agonists.

Turnaturi R, Parenti C, Prezzavento O, Marrazzo A, Pallaki P, Georgoussi Z, Amata E, Pasquinucci L.

Molecules. 2018 Mar 16;23(3). pii: E677. doi: 10.3390/molecules23030677.


In Vitro Evaluation of Sunscreen Safety: Effects of the Vehicle and Repeated Applications on Skin Permeation from Topical Formulations.

Montenegro L, Turnaturi R, Parenti C, Pasquinucci L.

Pharmaceutics. 2018 Feb 27;10(1). pii: E27. doi: 10.3390/pharmaceutics10010027.


Benzomorphan scaffold for opioid analgesics and pharmacological tools development: A comprehensive review.

Turnaturi R, Marrazzo A, Parenti C, Pasquinucci L.

Eur J Med Chem. 2018 Mar 25;148:410-422. doi: 10.1016/j.ejmech.2018.02.046. Epub 2018 Feb 17. Review.


Idebenone: Novel Strategies to Improve Its Systemic and Local Efficacy.

Montenegro L, Turnaturi R, Parenti C, Pasquinucci L.

Nanomaterials (Basel). 2018 Feb 5;8(2). pii: E87. doi: 10.3390/nano8020087. Review.


Connexins in the Central Nervous System: Physiological Traits and Neuroprotective Targets.

Vicario N, Zappalà A, Calabrese G, Gulino R, Parenti C, Gulisano M, Parenti R.

Front Physiol. 2017 Dec 18;8:1060. doi: 10.3389/fphys.2017.01060. eCollection 2017. Review.


Resveratrol-Loaded Lipid Nanocarriers: Correlation between In Vitro Occlusion Factor and In Vivo Skin Hydrating Effect.

Montenegro L, Parenti C, Turnaturi R, Pasquinucci L.

Pharmaceutics. 2017 Dec 10;9(4). pii: E58. doi: 10.3390/pharmaceutics9040058.


Novel Sigma-1 receptor antagonists: from opioids to small molecules: what is new?

Arena E, Dichiara M, Floresta G, Parenti C, Marrazzo A, Pittalà V, Amata E, Prezzavento O.

Future Med Chem. 2018 Jan;10(2):231-256. doi: 10.4155/fmc-2017-0164. Epub 2017 Nov 29. Review.


Chronic Treatment with Fluoxetine Induces Sex-Dependent Analgesic Effects and Modulates HDAC2 and mGlu2 Expression in Female Mice.

Zammataro M, Merlo S, Barresi M, Parenti C, Hu H, Sortino MA, Chiechio S.

Front Pharmacol. 2017 Oct 20;8:743. doi: 10.3389/fphar.2017.00743. eCollection 2017.


Rosemary Essential Oil-Loaded Lipid Nanoparticles: In Vivo Topical Activity from Gel Vehicles.

Montenegro L, Pasquinucci L, Zappalà A, Chiechio S, Turnaturi R, Parenti C.

Pharmaceutics. 2017 Oct 21;9(4). pii: E48. doi: 10.3390/pharmaceutics9040048.

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