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Items: 1 to 20 of 281

1.

Pan-cancer analysis of whole genomes.

ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium.

Nature. 2020 Feb;578(7793):82-93. doi: 10.1038/s41586-020-1969-6. Epub 2020 Feb 5.

2.

Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity.

Bravo-San Pedro JM, Sica V, Martins I, Pol J, Loos F, Maiuri MC, Durand S, Bossut N, Aprahamian F, Anagnostopoulos G, Niso-Santano M, Aranda F, Ramírez-Pardo I, Lallement J, Denom J, Boedec E, Gorwood P, Ramoz N, Clément K, Pelloux V, Rohia A, Pattou F, Raverdy V, Caiazzo R, Denis RGP, Boya P, Galluzzi L, Madeo F, Migrenne-Li S, Cruciani-Guglielmacci C, Tavernarakis N, López-Otín C, Magnan C, Kroemer G.

Cell Metab. 2019 Dec 3;30(6):1171. doi: 10.1016/j.cmet.2019.10.011. No abstract available.

PMID:
31801056
3.

Immunosuppression by Mutated Calreticulin Released from Malignant Cells.

Liu P, Zhao L, Loos F, Marty C, Xie W, Martins I, Lachkar S, Qu B, Waeckel-Énée E, Plo I, Vainchenker W, Perez F, Rodriguez D, López-Otin C, van Endert P, Zitvogel L, Kepp O, Kroemer G.

Mol Cell. 2020 Feb 20;77(4):748-760.e9. doi: 10.1016/j.molcel.2019.11.004. Epub 2019 Nov 27.

PMID:
31785928
4.

Differential mechanisms of tolerance to extreme environmental conditions in tardigrades.

Carrero D, Pérez-Silva JG, Quesada V, López-Otín C.

Sci Rep. 2019 Oct 17;9(1):14938. doi: 10.1038/s41598-019-51471-8.

5.

The U1 spliceosomal RNA is recurrently mutated in multiple cancers.

Shuai S, Suzuki H, Diaz-Navarro A, Nadeu F, Kumar SA, Gutierrez-Fernandez A, Delgado J, Pinyol M, López-Otín C, Puente XS, Taylor MD, Campo E, Stein LD.

Nature. 2019 Oct;574(7780):712-716. doi: 10.1038/s41586-019-1651-z. Epub 2019 Oct 9.

PMID:
31597163
6.

Global Proteome of LonP1+/- Mouse Embryonal Fibroblasts Reveals Impact on Respiratory Chain, but No Interdependence between Eral1 and Mitoribosomes.

Key J, Kohli A, Bárcena C, López-Otín C, Heidler J, Wittig I, Auburger G.

Int J Mol Sci. 2019 Sep 12;20(18). pii: E4523. doi: 10.3390/ijms20184523.

7.

Precise in vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction.

Suzuki K, Yamamoto M, Hernandez-Benitez R, Li Z, Wei C, Soligalla RD, Aizawa E, Hatanaka F, Kurita M, Reddy P, Ocampo A, Hishida T, Sakurai M, Nemeth AN, Nuñez Delicado E, Campistol JM, Magistretti P, Guillen P, Rodriguez Esteban C, Gong J, Yuan Y, Gu Y, Liu GH, López-Otín C, Wu J, Zhang K, Izpisua Belmonte JC.

Cell Res. 2019 Oct;29(10):804-819. doi: 10.1038/s41422-019-0213-0. Epub 2019 Aug 23.

PMID:
31444470
8.

Partial Loss of USP9X Function Leads to a Male Neurodevelopmental and Behavioral Disorder Converging on Transforming Growth Factor β Signaling.

Johnson BV, Kumar R, Oishi S, Alexander S, Kasherman M, Vega MS, Ivancevic A, Gardner A, Domingo D, Corbett M, Parnell E, Yoon S, Oh T, Lines M, Lefroy H, Kini U, Van Allen M, Grønborg S, Mercier S, Küry S, Bézieau S, Pasquier L, Raynaud M, Afenjar A, Billette de Villemeur T, Keren B, Désir J, Van Maldergem L, Marangoni M, Dikow N, Koolen DA, VanHasselt PM, Weiss M, Zwijnenburg P, Sa J, Reis CF, López-Otín C, Santiago-Fernández O, Fernández-Jaén A, Rauch A, Steindl K, Joset P, Goldstein A, Madan-Khetarpal S, Infante E, Zackai E, Mcdougall C, Narayanan V, Ramsey K, Mercimek-Andrews S, Pena L, Shashi V; Undiagnosed Diseases Network, Schoch K, Sullivan JA, Pinto E Vairo F, Pichurin PN, Ewing SA, Barnett SS, Klee EW, Perry MS, Koenig MK, Keegan CE, Schuette JL, Asher S, Perilla-Young Y, Smith LD, Rosenfeld JA, Bhoj E, Kaplan P, Li D, Oegema R, van Binsbergen E, van der Zwaag B, Smeland MF, Cutcutache I, Page M, Armstrong M, Lin AE, Steeves MA, Hollander ND, Hoffer MJV, Reijnders MRF, Demirdas S, Koboldt DC, Bartholomew D, Mosher TM, Hickey SE, Shieh C, Sanchez-Lara PA, Graham JM Jr, Tezcan K, Schaefer GB, Danylchuk NR, Asamoah A, Jackson KE, Yachelevich N, Au M, Pérez-Jurado LA, Kleefstra T, Penzes P, Wood SA, Burne T, Pierson TM, Piper M, Gécz J, Jolly LA.

Biol Psychiatry. 2020 Jan 15;87(2):100-112. doi: 10.1016/j.biopsych.2019.05.028. Epub 2019 Jun 29.

PMID:
31443933
9.

Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity.

Bravo-San Pedro JM, Sica V, Martins I, Pol J, Loos F, Maiuri MC, Durand S, Bossut N, Aprahamian F, Anagnostopoulos G, Niso-Santano M, Aranda F, Ramírez-Pardo I, Lallement J, Denom J, Boedec E, Gorwood P, Ramoz N, Clément K, Pelloux V, Rohia A, Pattou F, Raverdy V, Caiazzo R, Denis RGP, Boya P, Galluzzi L, Madeo F, Migrenne-Li S, Cruciani-Guglielmacci C, Tavernarakis N, López-Otín C, Magnan C, Kroemer G.

Cell Metab. 2019 Oct 1;30(4):754-767.e9. doi: 10.1016/j.cmet.2019.07.010. Epub 2019 Aug 15. Erratum in: Cell Metab. 2019 Dec 3;30(6):1171.

PMID:
31422903
10.

Insight into genetic predisposition to chronic lymphocytic leukemia from integrative epigenomics.

Speedy HE, Beekman R, Chapaprieta V, Orlando G, Law PJ, Martín-García D, Gutiérrez-Abril J, Catovsky D, Beà S, Clot G, Puiggròs M, Torrents D, Puente XS, Allan JM, López-Otín C, Campo E, Houlston RS, Martín-Subero JI.

Nat Commun. 2019 Aug 9;10(1):3615. doi: 10.1038/s41467-019-11582-2.

11.

Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice.

Bárcena C, Valdés-Mas R, Mayoral P, Garabaya C, Durand S, Rodríguez F, Fernández-García MT, Salazar N, Nogacka AM, Garatachea N, Bossut N, Aprahamian F, Lucia A, Kroemer G, Freije JMP, Quirós PM, López-Otín C.

Nat Med. 2019 Aug;25(8):1234-1242. doi: 10.1038/s41591-019-0504-5. Epub 2019 Jul 22.

PMID:
31332389
12.

Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging.

Ho YH, Del Toro R, Rivera-Torres J, Rak J, Korn C, García-García A, Macías D, González-Gómez C, Del Monte A, Wittner M, Waller AK, Foster HR, López-Otín C, Johnson RS, Nerlov C, Ghevaert C, Vainchenker W, Louache F, Andrés V, Méndez-Ferrer S.

Cell Stem Cell. 2019 Sep 5;25(3):407-418.e6. doi: 10.1016/j.stem.2019.06.007. Epub 2019 Jul 11.

13.

Decelerating ageing and biological clocks by autophagy.

Lopez-Otín C, Kroemer G.

Nat Rev Mol Cell Biol. 2019 Jul;20(7):385-386. doi: 10.1038/s41580-019-0149-8. No abstract available.

PMID:
31164727
14.

Moving Frailty Toward Clinical Practice: NIA Intramural Frailty Science Symposium Summary.

Walston J, Bandeen-Roche K, Buta B, Bergman H, Gill TM, Morley JE, Fried LP, Robinson TN, Afilalo J, Newman AB, López-Otín C, De Cabo R, Theou O, Studenski S, Cohen HJ, Ferrucci L.

J Am Geriatr Soc. 2019 Aug;67(8):1559-1564. doi: 10.1111/jgs.15928. Epub 2019 May 2.

PMID:
31045254
15.

Progerin accelerates atherosclerosis by inducing endoplasmic reticulum stress in vascular smooth muscle cells.

Hamczyk MR, Villa-Bellosta R, Quesada V, Gonzalo P, Vidak S, Nevado RM, Andrés-Manzano MJ, Misteli T, López-Otín C, Andrés V.

EMBO Mol Med. 2019 Apr;11(4). pii: e9736. doi: 10.15252/emmm.201809736.

16.

Withdrawal: Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3.

Mariño G, Salvador-Montoliu N, Fueyo A, Knecht E, Mizushima N, López-Otín C.

J Biol Chem. 2019 Jan 25;294(4):1435. doi: 10.1074/jbc.W118.007329. No abstract available.

17.

Withdrawal: Identification and characterization of human archaemetzincin-1 and -2, two novel members of a family of metalloproteases widely distributed in Archaea.

Díaz-Perales A, Quesada V, Peinado JR, Ugalde AP, Álvarez J, Suárez MF, Gomis-Rüth FX, López-Otín C.

J Biol Chem. 2019 Jan 25;294(4):1434. doi: 10.1074/jbc.W118.007328. No abstract available.

18.

Withdrawal: Identification of human aminopeptidase O, a novel metalloprotease with structural similarity to aminopeptidase B and leukotriene A4 hydrolase.

Díaz-Perales A, Quesada V, Sánchez LM, Ugalde AP, Suárez MF, Fueyo A, López-Otín C.

J Biol Chem. 2019 Jan 25;294(4):1433. doi: 10.1074/jbc.W118.007327. No abstract available.

19.

Withdrawal: Identification and characterization of human and mouse ovastacin: A novel metalloproteinase similar to hatching enzymes from arthropods, birds, amphibians, and fish.

Quesada V, Sánchez LM, Álvarez J, López-Otín C.

J Biol Chem. 2019 Jan 25;294(4):1432. doi: 10.1074/jbc.W118.007326. No abstract available.

20.

Withdrawal: Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy.

Mariño G, Uría JA, Puente XS, Quesada V, Bordallo J, López-Otín C.

J Biol Chem. 2019 Jan 25;294(4):1431. doi: 10.1074/jbc.W118.007325. No abstract available.

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