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J Appl Biomater Funct Mater. 2017 Jul 27;15(3):e251-e261. doi: 10.5301/jabfm.5000353.

Clinical, biomechanical and morphological assessment of anterior cruciate ligament Kevlar®-based artificial prosthesis in rabbit model.

Author information

1
Knee Unit, Department of Orthopaedics and Traumatology, Faculty of Medicine and Dr. José Eleuterio González University Hospital, Autonomous University of Nuevo León, Monterrey, Nuevo León - México.
2
Department of Human Anatomy, Faculty of Medicine, Autonomous University of Nuevo León, Monterrey, Nuevo León - México.
3
Department of Histology, Faculty of Medicine, Autonomous University of Nuevo León, Monterrey, Nuevo León - México.

Abstract

BACKGROUND:

The aim of this study was to evaluate the clinical, biomechanical and morphological characteristics of a Kevlar®-based prosthetic ligament as a synthetic graft of the anterior cruciate ligament (ACL) in an experimental animal model in rabbits.

METHODS:

A total of 27 knees of rabbits randomly divided into 3 groups (control, ACL excision and ACL replacement with a Kevlar® prosthesis) were analyzed using clinical, biomechanical and morphological tests at 6, 12 and 18 weeks postprocedure.

RESULTS:

The mean displacement in mechanical testing was 0.73 ± 0.06 mm, 1.58 ± 0.19 mm and 0.94 ± 0.20 mm for the control, ACL excision and ACL replacement with synthetic prosthesis groups, respectively. The results showed an improvement in the stability of the knee with the use of the Kevlar® synthetic prosthesis in the biomechanical testing (p<0.05) compared with rabbits that underwent ACL excision, in addition to displacements that were larger but comparable to that in the control group (p>0.05), between the replacement group and the control group. The histological study revealed a good morphological adaptation of the synthetic material to the knee.

CONCLUSIONS:

This study proposes a new animal model for the placement and evaluation of Kevlar®-based synthetic ACL implants. The studied prosthesis showed promising behavior in the clinical and biomechanical tests and in the histological analysis. This study lays the foundation for further basic and clinical studies of artificial ACL prostheses using this material.

PMID:
28478617
DOI:
10.5301/jabfm.5000353
[Indexed for MEDLINE]

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