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Items: 1 to 20 of 38


Systematic clinical evidence review of NASHA (Durolane hyaluronic acid) for the treatment of knee osteoarthritis.

Leighton R, Fitzpatrick J, Smith H, Crandall D, Flannery CR, Conrozier T.

Open Access Rheumatol. 2018 May 21;10:43-54. doi: 10.2147/OARRR.S162127. eCollection 2018. Review.


Serine protease HTRA1 antagonizes transforming growth factor-β signaling by cleaving its receptors and loss of HTRA1 in vivo enhances bone formation.

Graham JR, Chamberland A, Lin Q, Li XJ, Dai D, Zeng W, Ryan MS, Rivera-Bermúdez MA, Flannery CR, Yang Z.

PLoS One. 2013 Sep 11;8(9):e74094. doi: 10.1371/journal.pone.0074094. eCollection 2013.


Disposition of human recombinant lubricin in naive rats and in a rat model of post-traumatic arthritis after intra-articular or intravenous administration.

Vugmeyster Y, Wang Q, Xu X, Harrold J, Daugusta D, Li J, Zollner R, Flannery CR, Rivera-Bermúdez MA.

AAPS J. 2012 Mar;14(1):97-104. doi: 10.1208/s12248-011-9315-4. Epub 2012 Jan 7.


Not all lubricin isoforms are substituted with a glycosaminoglycan chain.

Lord MS, Estrella RP, Chuang CY, Youssef P, Karlsson NG, Flannery CR, Whitelock JM.

Connect Tissue Res. 2012;53(2):132-41. doi: 10.3109/03008207.2011.614364. Epub 2011 Oct 3.


Tenascin-C induces inflammatory mediators and matrix degradation in osteoarthritic cartilage.

Patel L, Sun W, Glasson SS, Morris EA, Flannery CR, Chockalingam PS.

BMC Musculoskelet Disord. 2011 Jul 15;12:164. doi: 10.1186/1471-2474-12-164.


Changes in serum and synovial fluid biomarkers after acute injury (NCT00332254).

Catterall JB, Stabler TV, Flannery CR, Kraus VB.

Arthritis Res Ther. 2010;12(6):R229. doi: 10.1186/ar3216. Epub 2010 Dec 31.


Lubricin: Its Presence in Repair Cartilage following Treatment with Autologous Chondrocyte Implantation.

Roberts S, Menage J, Flannery CR, Richardson JB.

Cartilage. 2010 Oct;1(4):298-305. doi: 10.1177/1947603510370156.


Novel therapies in OA.

Flannery CR.

Curr Drug Targets. 2010 May;11(5):614-9.


LXR modulation blocks prostaglandin E2 production and matrix degradation in cartilage and alleviates pain in a rat osteoarthritis model.

Li N, Rivéra-Bermúdez MA, Zhang M, Tejada J, Glasson SS, Collins-Racie LA, Lavallie ER, Wang Y, Chang KC, Nagpal S, Morris EA, Flannery CR, Yang Z.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3734-9. doi: 10.1073/pnas.0911377107. Epub 2010 Feb 3.


Identification of a novel HtrA1-susceptible cleavage site in human aggrecan: evidence for the involvement of HtrA1 in aggrecan proteolysis in vivo.

Chamberland A, Wang E, Jones AR, Collins-Racie LA, LaVallie ER, Huang Y, Liu L, Morris EA, Flannery CR, Yang Z.

J Biol Chem. 2009 Oct 2;284(40):27352-9. doi: 10.1074/jbc.M109.037051. Epub 2009 Aug 5.


Catabolic responses of chondrocyte-seeded peptide hydrogel to dynamic compression.

Kisiday JD, Lee JH, Siparsky PN, Frisbie DD, Flannery CR, Sandy JD, Grodzinsky AJ.

Ann Biomed Eng. 2009 Jul;37(7):1368-75. doi: 10.1007/s10439-009-9699-9. Epub 2009 May 5.


Prevention of cartilage degeneration in a rat model of osteoarthritis by intraarticular treatment with recombinant lubricin.

Flannery CR, Zollner R, Corcoran C, Jones AR, Root A, Rivera-Bermúdez MA, Blanchet T, Gleghorn JP, Bonassar LJ, Bendele AM, Morris EA, Glasson SS.

Arthritis Rheum. 2009 Mar;60(3):840-7. doi: 10.1002/art.24304.


Alteration of articular cartilage frictional properties by transforming growth factor beta, interleukin-1beta, and oncostatin M.

Gleghorn JP, Jones AR, Flannery CR, Bonassar LJ.

Arthritis Rheum. 2009 Feb;60(2):440-9. doi: 10.1002/art.24259.


Modulation of lubricin biosynthesis and tissue surface properties following cartilage mechanical injury.

Jones AR, Chen S, Chai DH, Stevens AL, Gleghorn JP, Bonassar LJ, Grodzinsky AJ, Flannery CR.

Arthritis Rheum. 2009 Jan;60(1):133-42. doi: 10.1002/art.24143.


Boundary mode lubrication of articular cartilage by recombinant human lubricin.

Gleghorn JP, Jones AR, Flannery CR, Bonassar LJ.

J Orthop Res. 2009 Jun;27(6):771-7. doi: 10.1002/jor.20798.


N-((8-hydroxy-5-substituted-quinolin-7-yl)(phenyl)methyl)-2-phenyloxy/amino-acetamide inhibitors of ADAMTS-5 (Aggrecanase-2).

Gilbert AM, Bursavich MG, Lombardi S, Georgiadis KE, Reifenberg E, Flannery CR, Morris EA.

Bioorg Med Chem Lett. 2008 Dec 15;18(24):6454-7. doi: 10.1016/j.bmcl.2008.10.065. Epub 2008 Oct 18.


Comparative proteomic characterization of articular cartilage tissue from normal donors and patients with osteoarthritis.

Wu J, Liu W, Bemis A, Wang E, Qiu Y, Morris EA, Flannery CR, Yang Z.

Arthritis Rheum. 2007 Nov;56(11):3675-84.


5'-Phenyl-3'H-spiro[indoline-3,2'-[1,3,4]thiadiazol]-2-one inhibitors of ADAMTS-5 (aggrecanase-2).

Bursavich MG, Gilbert AM, Lombardi S, Georgiadis KE, Reifenberg E, Flannery CR, Morris EA.

Bioorg Med Chem Lett. 2007 Oct 15;17(20):5630-3. Epub 2007 Aug 19.


5-((1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one inhibitors of ADAMTS-5.

Gilbert AM, Bursavich MG, Lombardi S, Georgiadis KE, Reifenberg E, Flannery CR, Morris EA.

Bioorg Med Chem Lett. 2007 Mar 1;17(5):1189-92. Epub 2006 Dec 12.


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