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Sensors (Basel). 2016 May 28;16(6). pii: E778. doi: 10.3390/s16060778.

Towards a Multifunctional Electrochemical Sensing and Niosome Generation Lab-on-Chip Platform Based on a Plug-and-Play Concept.

Author information

1
Electrical and Computer Engineering Deptartment, Faculty of Sciences and Engineering, Université Laval, Québec City, QC G1V 0A6, Canada. adnane.kara.1@ulaval.ca.
2
Department of Chemistry, Faculty of Sciences and Engineering, Université Laval, Québec City, QC G1V 0A6, Canada. adnane.kara.1@ulaval.ca.
3
Electrical and Computer Engineering Deptartment, Faculty of Sciences and Engineering, Université Laval, Québec City, QC G1V 0A6, Canada. camille.rouillard.1@ulaval.ca.
4
Department of Chemistry, Faculty of Sciences and Engineering, Université Laval, Québec City, QC G1V 0A6, Canada. camille.rouillard.1@ulaval.ca.
5
Ophthalmology Department, Faculty of Medecine, Université Laval, Québec City, QC G1V 0A6, Canada. camille.rouillard.1@ulaval.ca.
6
Electrical and Computer Engineering Deptartment, Faculty of Sciences and Engineering, Université Laval, Québec City, QC G1V 0A6, Canada. jessy.mathault.1@ulaval.ca.
7
Electrical and Computer Engineering Deptartment, Faculty of Sciences and Engineering, Université Laval, Québec City, QC G1V 0A6, Canada. martin.boisvert.4@ulaval.ca.
8
Department of Chemistry, Faculty of Sciences and Engineering, Université Laval, Québec City, QC G1V 0A6, Canada. martin.boisvert.4@ulaval.ca.
9
Electrical and Computer Engineering Deptartment, Faculty of Sciences and Engineering, Université Laval, Québec City, QC G1V 0A6, Canada. frederic.tessier.1@ulaval.ca.
10
Electrical and Computer Engineering Deptartment, Faculty of Sciences and Engineering, Université Laval, Québec City, QC G1V 0A6, Canada. hamza.landari.1@ulaval.ca.
11
Research Center of CHU de Quebec, (Centre Hospitalier Universitaire)-Université Laval, Québec City, QC G1V 0A6, Canada. Imene.Melki@crchudequebec.ulaval.ca.
12
Centre de Recherche du Centre Hospitalier Universitaire de Québec (CR-CHUQ), Axe Médecine Régénératrice, Québec City, QC G1L 3L5, Canada. myriam.laprise-pelletier.1@ulaval.ca.
13
Centre de Recherche sur les Matériaux Avancés (CERMA), Université Laval, Québec City, QC G1V 0A6, Canada. myriam.laprise-pelletier.1@ulaval.ca.
14
Département de Génie des Mines, de la Métallurgie et des Matériaux, Université Laval, Québec City, QC G1V 0A6, Canada. myriam.laprise-pelletier.1@ulaval.ca.
15
Ophthalmology Department, Faculty of Medecine, Université Laval, Québec City, QC G1V 0A6, Canada. Elodie.Boisselier@fmed.ulaval.ca.
16
Centre de Recherche du Centre Hospitalier Universitaire de Québec (CR-CHUQ), Axe Médecine Régénératrice, Québec City, QC G1L 3L5, Canada. Marc-Andre.Fortin@gmn.ulaval.ca.
17
Centre de Recherche sur les Matériaux Avancés (CERMA), Université Laval, Québec City, QC G1V 0A6, Canada. Marc-Andre.Fortin@gmn.ulaval.ca.
18
Département de Génie des Mines, de la Métallurgie et des Matériaux, Université Laval, Québec City, QC G1V 0A6, Canada. Marc-Andre.Fortin@gmn.ulaval.ca.
19
Research Center of CHU de Quebec, (Centre Hospitalier Universitaire)-Université Laval, Québec City, QC G1V 0A6, Canada. Eric.Boilard@crchudequebec.ulaval.ca.
20
Department of Chemistry, Faculty of Sciences and Engineering, Université Laval, Québec City, QC G1V 0A6, Canada. Jesse.Greener@chm.ulaval.ca.
21
Electrical and Computer Engineering Deptartment, Faculty of Sciences and Engineering, Université Laval, Québec City, QC G1V 0A6, Canada. amine.miled@gel.ulaval.ca.

Abstract

In this paper, we present a new modular lab on a chip design for multimodal neurotransmitter (NT) sensing and niosome generation based on a plug-and-play concept. This architecture is a first step toward an automated platform for an automated modulation of neurotransmitter concentration to understand and/or treat neurodegenerative diseases. A modular approach has been adopted in order to handle measurement or drug delivery or both measurement and drug delivery simultaneously. The system is composed of three fully independent modules: three-channel peristaltic micropumping system, a three-channel potentiostat and a multi-unit microfluidic system composed of pseudo-Y and cross-shape channels containing a miniature electrode array. The system was wirelessly controlled by a computer interface. The system is compact, with all the microfluidic and sensing components packaged in a 5 cm × 4 cm × 4 cm box. Applied to serotonin, a linear calibration curve down to 0.125 mM, with a limit of detection of 31 μ M was collected at unfunctionalized electrodes. Added sensitivity and selectivity was achieved by incorporating functionalized electrodes for dopamine sensing. Electrode functionalization was achieved with gold nanoparticles and using DNA and o-phenylene diamine polymer. The as-configured platform is demonstrated as a central component toward an "intelligent" drug delivery system based on a feedback loop to monitor drug delivery.

KEYWORDS:

lab-on-chip; modular microfluidics; system integration

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