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Items: 1 to 20 of 128

1.

A single ultrasensitive assay for detection and discrimination of tau aggregates of Alzheimer and Pick diseases.

Metrick MA 2nd, Ferreira NDC, Saijo E, Kraus A, Newell K, Zanusso G, Vendruscolo M, Ghetti B, Caughey B.

Acta Neuropathol Commun. 2020 Feb 22;8(1):22. doi: 10.1186/s40478-020-0887-z.

2.

Correction to: 4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration.

Saijo E, Metrick MA 2nd, Koga S, Parchi P, Litvan I, Spina S, Boxer A, Rojas JC, Galasko D, Kraus A, Rossi M, Newell K, Zanusso G, Grinberg LT, Seeley WW, Ghetti B, Dickson DW, Caughey B.

Acta Neuropathol. 2020 Jan;139(1):79-81. doi: 10.1007/s00401-019-02092-y.

PMID:
31748840
3.

Transmissibility versus Pathogenicity of Self-Propagating Protein Aggregates.

Caughey B, Kraus A.

Viruses. 2019 Nov 9;11(11). pii: E1044. doi: 10.3390/v11111044. Review.

4.

Million-fold sensitivity enhancement in proteopathic seed amplification assays for biospecimens by Hofmeister ion comparisons.

Metrick MA 2nd, do Carmo Ferreira N, Saijo E, Hughson AG, Kraus A, Orrú C, Miller MW, Zanusso G, Ghetti B, Vendruscolo M, Caughey B.

Proc Natl Acad Sci U S A. 2019 Nov 12;116(46):23029-23039. doi: 10.1073/pnas.1909322116. Epub 2019 Oct 22.

PMID:
31641070
5.

4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration.

Saijo E, Metrick MA 2nd, Koga S, Parchi P, Litvan I, Spina S, Boxer A, Rojas JC, Galasko D, Kraus A, Rossi M, Newell K, Zanusso G, Grinberg LT, Seeley WW, Ghetti B, Dickson DW, Caughey B.

Acta Neuropathol. 2020 Jan;139(1):63-77. doi: 10.1007/s00401-019-02080-2. Epub 2019 Oct 16. Erratum in: Acta Neuropathol. 2019 Nov 20;:.

PMID:
31616982
6.

Antisense oligonucleotides extend survival of prion-infected mice.

Raymond GJ, Zhao HT, Race B, Raymond LD, Williams K, Swayze EE, Graffam S, Le J, Caron T, Stathopoulos J, O'Keefe R, Lubke LL, Reidenbach AG, Kraus A, Schreiber SL, Mazur C, Cabin DE, Carroll JB, Minikel EV, Kordasiewicz H, Caughey B, Vallabh SM.

JCI Insight. 2019 Jul 30;5. pii: 131175. doi: 10.1172/jci.insight.131175.

7.

Association of Blood and Cerebrospinal Fluid Tau Level and Other Biomarkers With Survival Time in Sporadic Creutzfeldt-Jakob Disease.

Staffaroni AM, Kramer AO, Casey M, Kang H, Rojas JC, Orrú CD, Caughey B, Allen IE, Kramer JH, Rosen HJ, Blennow K, Zetterberg H, Geschwind MD.

JAMA Neurol. 2019 May 6. doi: 10.1001/jamaneurol.2019.1071. [Epub ahead of print]

PMID:
31058916
8.

Early and Pre-Clinical Detection of Prion Seeding Activity in Cerebrospinal Fluid of Goats using Real-Time Quaking-Induced Conversion Assay.

Favole A, Mazza M, Vallino Costassa E, D'Angelo A, Lombardi G, Marconi P, Crociara P, Berrone E, Gallo M, Palmitessa C, Orrù CD, Caughey B, Acutis PL, Caramelli M, Casalone C, Corona C.

Sci Rep. 2019 Apr 16;9(1):6173. doi: 10.1038/s41598-019-42449-7.

9.

Publisher Correction: Early preclinical detection of prions in the skin of prion-infected animals.

Wang Z, Manca M, Foutz A, Camacho MV, Raymond GJ, Race B, Orru CD, Yuan J, Shen P, Li B, Lang Y, Dang J, Adornato A, Williams K, Maurer NR, Gambetti P, Xu B, Surewicz W, Petersen RB, Dong X, Appleby BS, Caughey B, Cui L, Kong Q, Zou WQ.

Nat Commun. 2019 Feb 4;10(1):640. doi: 10.1038/s41467-019-08648-6.

10.

Early preclinical detection of prions in the skin of prion-infected animals.

Wang Z, Manca M, Foutz A, Camacho MV, Raymond GJ, Race B, Orru CD, Yuan J, Shen P, Li B, Lang Y, Dang J, Adornato A, Williams K, Maurer NR, Gambetti P, Xu B, Surewicz W, Petersen RB, Dong X, Appleby BS, Caughey B, Cui L, Kong Q, Zou WQ.

Nat Commun. 2019 Jan 16;10(1):247. doi: 10.1038/s41467-018-08130-9. Erratum in: Nat Commun. 2019 Feb 4;10(1):640.

11.

The prion 2018 round tables (I): the structure of PrPSc.

Baskakov IV, Caughey B, Requena JR, Sevillano AM, Surewicz WK, Wille H.

Prion. 2019 Jan;13(1):46-52. doi: 10.1080/19336896.2019.1569450.

12.

Seeding selectivity and ultrasensitive detection of tau aggregate conformers of Alzheimer disease.

Kraus A, Saijo E, Metrick MA 2nd, Newell K, Sigurdson CJ, Zanusso G, Ghetti B, Caughey B.

Acta Neuropathol. 2019 Apr;137(4):585-598. doi: 10.1007/s00401-018-1947-3. Epub 2018 Dec 20.

13.

Prion Seeds Distribute throughout the Eyes of Sporadic Creutzfeldt-Jakob Disease Patients.

Orrù CD, Soldau K, Cordano C, Llibre-Guerra J, Green AJ, Sanchez H, Groveman BR, Edland SD, Safar JG, Lin JH, Caughey B, Geschwind MD, Sigurdson CJ.

mBio. 2018 Nov 20;9(6). pii: e02095-18. doi: 10.1128/mBio.02095-18.

14.

Cell-free prion protein conversion assays in screening for anti-prion drug candidates

do Carmo Ferreira N, Caughey B.

Curr Opin Pharmacol. 2019 Feb;44:1-7. doi: 10.1016/j.coph.2018.10.001. Epub 2018 Nov 7. Review.

PMID:
30412823
15.

Prion-related peripheral neuropathy in sporadic Creutzfeldt-Jakob disease.

Baiardi S, Redaelli V, Ripellino P, Rossi M, Franceschini A, Moggio M, Sola P, Ladogana A, Fociani P, Magherini A, Capellari S, Giese A, Caughey B, Caroppo P, Parchi P.

J Neurol Neurosurg Psychiatry. 2019 Apr;90(4):424-427. doi: 10.1136/jnnp-2018-319221. Epub 2018 Oct 24.

PMID:
30355606
16.

Ultrasensitive RT-QuIC Seed Amplification Assays for Disease-Associated Tau, α-Synuclein, and Prion Aggregates.

Saijo E, Groveman BR, Kraus A, Metrick M, Orrù CD, Hughson AG, Caughey B.

Methods Mol Biol. 2019;1873:19-37. doi: 10.1007/978-1-4939-8820-4_2.

PMID:
30341601
17.

Design, implementation, and interpretation of amplification studies for prion detection.

Haley NJ, Richt JA, Davenport KA, Henderson DM, Hoover EA, Manca M, Caughey B, Marthaler D, Bartz J, Gilch S.

Prion. 2018 Mar 4;12(2):73-82. doi: 10.1080/19336896.2018.1443000. Epub 2018 Mar 9.

18.

Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC.

Groveman BR, Orrù CD, Hughson AG, Raymond LD, Zanusso G, Ghetti B, Campbell KJ, Safar J, Galasko D, Caughey B.

Acta Neuropathol Commun. 2018 Feb 9;6(1):7. doi: 10.1186/s40478-018-0508-2.

19.

Prion seeding activity and infectivity in skin samples from patients with sporadic Creutzfeldt-Jakob disease.

Orrú CD, Yuan J, Appleby BS, Li B, Li Y, Winner D, Wang Z, Zhan YA, Rodgers M, Rarick J, Wyza RE, Joshi T, Wang GX, Cohen ML, Zhang S, Groveman BR, Petersen RB, Ironside JW, Quiñones-Mateu ME, Safar JG, Kong Q, Caughey B, Zou WQ.

Sci Transl Med. 2017 Nov 22;9(417). pii: eaam7785. doi: 10.1126/scitranslmed.aam7785.

20.

Role of the central lysine cluster and scrapie templating in the transmissibility of synthetic prion protein aggregates.

Groveman BR, Raymond GJ, Campbell KJ, Race B, Raymond LD, Hughson AG, Orrú CD, Kraus A, Phillips K, Caughey B.

PLoS Pathog. 2017 Sep 14;13(9):e1006623. doi: 10.1371/journal.ppat.1006623. eCollection 2017 Sep.

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