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Items: 1 to 20 of 42


Anti-inflammatory Effects of Persimmon (Diospyros kaki L.) in Experimental Rodent Rheumatoid Arthritis.

Direito R, Rocha J, Serra AT, Fernandes A, Freitas M, Fernandes E, Pinto R, Bronze R, Sepodes B, Figueira ME.

J Diet Suppl. 2019 Jul 30:1-21. doi: 10.1080/19390211.2019.1645256. [Epub ahead of print]


Phytosomes with Persimmon (Diospyros kaki L.) Extract: Preparation and Preliminary Demonstration of In Vivo Tolerability.

Direito R, Reis C, Roque L, Gonçalves M, Sanches-Silva A, Gaspar MM, Pinto R, Rocha J, Sepodes B, Rosário Bronze M, Eduardo Figueira M.

Pharmaceutics. 2019 Jun 22;11(6). pii: E296. doi: 10.3390/pharmaceutics11060296.


Reduction of Inflammation and Colon Injury by a Spearmint Phenolic Extract in Experimental Bowel Disease in Mice.

Direito R, Rocha J, Lima A, Gonçalves MM, Duarte MP, Mateus V, Sousa C, Fernandes A, Pinto R, Boavida Ferreira R, Sepodes B, Figueira ME.

Medicines (Basel). 2019 Jun 6;6(2). pii: E65. doi: 10.3390/medicines6020065.


Defining orphan conditions in the context of the European orphan regulation: challenges and evolution.

O'Connor DJ, Sheean ME, Hofer MP, Tsigkos S, Mariz S, Fregonese L, Larsson K, Hivert V, Westermark K, Naumann-Winter F, Stoyanova-Beninska V, Barišić I, Capovilla G, Magrelli A, Sepodes B.

Nat Rev Drug Discov. 2019 Jul;18(7):479-480. doi: 10.1038/nrd.2018.128. No abstract available.


Hurdles in gene therapy regulatory approval: a retrospective analysis of European Marketing Authorization Applications.

Carvalho M, Martins AP, Sepodes B.

Drug Discov Today. 2019 Mar;24(3):823-828. doi: 10.1016/j.drudis.2018.12.007. Epub 2018 Dec 21. Review.


Optimising bench science to withstand regulatory scrutiny.

Borg JJ, Melchiorri D, Sepodes B, Caramella CM, Tomino C, Micallef B, Serracino-Inglott A, Nistico R.

Pharmacol Res. 2019 Jan;139:491-493. doi: 10.1016/j.phrs.2018.10.014. Epub 2018 Oct 12. No abstract available.


Hemin reduces inflammation associated with TNBS-induced colitis.

Mateus V, Rocha J, Mota-Filipe H, Sepodes B, Pinto R.

Clin Exp Gastroenterol. 2018 Sep 18;11:325-334. doi: 10.2147/CEG.S166197. eCollection 2018.


Regulatory and Scientific Advancements in Gene Therapy: State-of-the-Art of Clinical Applications and of the Supporting European Regulatory Framework.

Carvalho M, Sepodes B, Martins AP.

Front Med (Lausanne). 2017 Oct 26;4:182. doi: 10.3389/fmed.2017.00182. eCollection 2017. Review.


Comparative analysis of the scope of European Union paediatric investigation plans with corresponding orphan designations.

Ecker A, Mariz S, Naumann-Winter F, Norga K, Barisic I, Girard T, Tomasi P, Mentzer D, Sepodes B.

Arch Dis Child. 2018 May;103(5):427-430. doi: 10.1136/archdischild-2017-313352. Epub 2017 Oct 31.


Demonstrating significant benefit of orphan medicines: analysis of 15 years of experience in Europe.

Fregonese L, Greene L, Hofer M, Magrelli A, Naumann-Winter F, Larsson K, Sheean M, Stoyanova-Beninska V, Tsigkos S, Westermark K, Sepodes B.

Drug Discov Today. 2018 Jan;23(1):90-100. doi: 10.1016/j.drudis.2017.09.010. Epub 2017 Oct 9. Review.


Nonclinical data supporting orphan medicinal product designations: lessons from rare neurological conditions.

Sheean ME, Stoyanova-Beninska V, Capovilla G, Duarte D, Hofer MP, Hoffmann M, Magrelli A, Mariz S, Tsigkos S, Shaili E, Polsinelli B, Ricciardi M, Bonelli M, Balabanov P, Larsson K, Sepodes B.

Drug Discov Today. 2018 Jan;23(1):26-48. doi: 10.1016/j.drudis.2017.09.015. Epub 2017 Oct 4. Review.


Thiadiazolidinone-8 Ameliorates Inflammation Associated with Experimental Colitis in Mice.

Mateus V, Rocha J, Alves P, Mota-Filipe H, Sepodes B, Pinto R.

Pharmacology. 2018;101(1-2):35-42. doi: 10.1159/000471808. Epub 2017 Sep 30.


Development of Exon Skipping Therapies for Duchenne Muscular Dystrophy: A Critical Review and a Perspective on the Outstanding Issues.

Aartsma-Rus A, Straub V, Hemmings R, Haas M, Schlosser-Weber G, Stoyanova-Beninska V, Mercuri E, Muntoni F, Sepodes B, Vroom E, Balabanov P.

Nucleic Acid Ther. 2017 Oct;27(5):251-259. doi: 10.1089/nat.2017.0682. Epub 2017 Aug 10. Review.


Establishing rarity in the context of orphan medicinal product designation in the European Union.

Tsigkos S, Hofer MP, Sheean ME, Mariz S, Larsson K, Naumann-Winter F, Fregonese L, Sepodes B.

Drug Discov Today. 2018 Mar;23(3):681-686. doi: 10.1016/j.drudis.2017.06.003. Epub 2017 Jun 21. Review.


Advanced Therapy Medicinal Products for Rare Diseases: State of Play of Incentives Supporting Development in Europe.

Farkas AM, Mariz S, Stoyanova-Beninska V, Celis P, Vamvakas S, Larsson K, Sepodes B.

Front Med (Lausanne). 2017 May 16;4:53. doi: 10.3389/fmed.2017.00053. eCollection 2017.


Dyospiros kaki phenolics inhibit colitis and colon cancer cell proliferation, but not gelatinase activities.

Direito R, Lima A, Rocha J, Ferreira RB, Mota J, Rebelo P, Fernandes A, Pinto R, Alves P, Bronze R, Sepodes B, Figueira ME.

J Nutr Biochem. 2017 Aug;46:100-108. doi: 10.1016/j.jnutbio.2017.03.002. Epub 2017 Mar 30.


Evolving prevalence of haematological malignancies in orphan designation procedures in the European Union.

Polsinelli B, Tsigkos S, Naumann-Winter F, Mariz S, Sepodes B.

Orphanet J Rare Dis. 2017 Jan 21;12(1):17. doi: 10.1186/s13023-017-0567-7.


Protective effects of a blueberry extract in acute inflammation and collagen-induced arthritis in the rat.

Figueira ME, Oliveira M, Direito R, Rocha J, Alves P, Serra AT, Duarte C, Bronze R, Fernandes A, Brites D, Freitas M, Fernandes E, Sepodes B.

Biomed Pharmacother. 2016 Oct;83:1191-1202. doi: 10.1016/j.biopha.2016.08.040. Epub 2016 Aug 20.


Anti-Inflammatory Effect of Erythropoietin in the TNBS-induced Colitis.

Mateus V, Rocha J, Alves P, Mota-Filipe H, Sepodes B, Pinto RM.

Basic Clin Pharmacol Toxicol. 2017 Feb;120(2):138-145. doi: 10.1111/bcpt.12663. Epub 2016 Nov 23.


Stakeholder cooperation to overcome challenges in orphan medicine development: the example of Duchenne muscular dystrophy.

Straub V, Balabanov P, Bushby K, Ensini M, Goemans N, De Luca A, Pereda A, Hemmings R, Campion G, Kaye E, Arechavala-Gomeza V, Goyenvalle A, Niks E, Veldhuizen O, Furlong P, Stoyanova-Beninska V, Wood MJ, Johnson A, Mercuri E, Muntoni F, Sepodes B, Haas M, Vroom E, Aartsma-Rus A.

Lancet Neurol. 2016 Jul;15(8):882-890. doi: 10.1016/S1474-4422(16)30035-7. Review.


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