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Items: 1 to 20 of 71


Backbone resonance assignments of innate immune evasion protein EapH2 from the S. aureus.

Herrera AI, Dubey A, Geisbrecht BV, Arthanari H, Prakash O.

Biomol NMR Assign. 2019 Apr;13(1):219-222. doi: 10.1007/s12104-019-09880-3. Epub 2019 Feb 7.


Investigation of Human Neutrophil Elastase Inhibition by Staphylococcus aureus EapH1: The Key Role Played by Arginine 89.

Herdendorf TJ, Geisbrecht BV.

Biochemistry. 2018 Dec 18;57(50):6888-6896. doi: 10.1021/acs.biochem.8b01134. Epub 2018 Nov 30.


The Staphylococcus aureus Extracellular Adherence Protein Eap Is a DNA Binding Protein Capable of Blocking Neutrophil Extracellular Trap Formation.

Eisenbeis J, Saffarzadeh M, Peisker H, Jung P, Thewes N, Preissner KT, Herrmann M, Molle V, Geisbrecht BV, Jacobs K, Bischoff M.

Front Cell Infect Microbiol. 2018 Jul 9;8:235. doi: 10.3389/fcimb.2018.00235. eCollection 2018.


Using disruptive insertional mutagenesis to identify the in situ structure-function landscape of the Shigella translocator protein IpaB.

Barta ML, Tachiyama S, Muthuramalingam M, Arizmendi O, Villanueva CE, Ramyar KX, Geisbrecht BV, Lovell S, Battaile KP, Picking WL, Picking WD.

Protein Sci. 2018 Aug;27(8):1392-1406. doi: 10.1002/pro.3428. Epub 2018 May 3.


Identification and structural characterization of a novel myeloperoxidase inhibitor from Staphylococcus delphini.

Ploscariu NT, de Jong NWM, van Kessel KPM, van Strijp JAG, Geisbrecht BV.

Arch Biochem Biophys. 2018 May 1;645:1-11. doi: 10.1016/ Epub 2018 Mar 7.


Quantitative monitoring of two simultaneously binding species using Label-Enhanced surface plasmon resonance.

Eng L, Garcia BL, Geisbrecht BV, Hanning A.

Biochem Biophys Res Commun. 2018 Feb 26;497(1):133-138. doi: 10.1016/j.bbrc.2018.02.040. Epub 2018 Feb 7.


Identification of a staphylococcal complement inhibitor with broad host specificity in equid Staphylococcus aureus strains.

de Jong NWM, Vrieling M, Garcia BL, Koop G, Brettmann M, Aerts PC, Ruyken M, van Strijp JAG, Holmes M, Harrison EM, Geisbrecht BV, Rooijakkers SHM.

J Biol Chem. 2018 Mar 23;293(12):4468-4477. doi: 10.1074/jbc.RA117.000599. Epub 2018 Feb 5.


1H, 15N, and 13C resonance assignments of the third domain from the S. aureus innate immune evasion protein Eap.

Herrera AI, Ploscariu NT, Geisbrecht BV, Prakash O.

Biomol NMR Assign. 2018 Apr;12(1):175-178. doi: 10.1007/s12104-018-9804-9. Epub 2018 Jan 25.


Mechanistic Insights into Dye-Decolorizing Peroxidase Revealed by Solvent Isotope and Viscosity Effects.

Shrestha R, Huang G, Meekins DA, Geisbrecht BV, Li P.

ACS Catal. 2017 Sep 1;7(9):6352-6364. doi: 10.1021/acscatal.7b01861. Epub 2017 Aug 9.


Identification of Surface-Exposed Protein Radicals and A Substrate Oxidation Site in A-Class Dye-Decolorizing Peroxidase from Thermomonospora curvata.

Shrestha R, Chen X, Ramyar KX, Hayati Z, Carlson EA, Bossmann SH, Song L, Geisbrecht BV, Li P.

ACS Catal. 2016 Dec 2;6(12):8036-8047. doi: 10.1021/acscatal.6b01952. Epub 2016 Oct 12.


A structurally dynamic N-terminal region drives function of the staphylococcal peroxidase inhibitor (SPIN).

de Jong NWM, Ploscariu NT, Ramyar KX, Garcia BL, Herrera AI, Prakash O, Katz BB, Leidal KG, Nauseef WM, van Kessel KPM, van Strijp JAG, Geisbrecht BV.

J Biol Chem. 2018 Feb 16;293(7):2260-2271. doi: 10.1074/jbc.RA117.000134. Epub 2018 Jan 5.


Evidence for multiple modes of neutrophil serine protease recognition by the EAP family of Staphylococcal innate immune evasion proteins.

Stapels DAC, Woehl JL, Milder FJ, Tromp AT, van Batenburg AA, de Graaf WC, Broll SC, White NM, Rooijakkers SHM, Geisbrecht BV.

Protein Sci. 2018 Feb;27(2):509-522. doi: 10.1002/pro.3342. Epub 2017 Nov 21.


Backbone and side-chain 1H, 15N, and 13C resonance assignments of a novel Staphylococcal inhibitor of myeloperoxidase.

Ploscariu NT, Herrera AI, Jayanthi S, Suresh Kumar TK, Geisbrecht BV, Prakash O.

Biomol NMR Assign. 2017 Oct;11(2):285-288. doi: 10.1007/s12104-017-9764-5. Epub 2017 Aug 16.


Immune evasion by a staphylococcal inhibitor of myeloperoxidase.

de Jong NWM, Ramyar KX, Guerra FE, Nijland R, Fevre C, Voyich JM, McCarthy AJ, Garcia BL, van Kessel KPM, van Strijp JAG, Geisbrecht BV, Haas PA.

Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):9439-9444. doi: 10.1073/pnas.1707032114. Epub 2017 Aug 14.


Enterotoxigenic Escherichia coli Flagellin Inhibits TNF-Induced NF-κB Activation in Intestinal Epithelial Cells.

Wang G, Geisbrecht BV, Rueter C, Hardwidge PR.

Pathogens. 2017 May 17;6(2). pii: E18. doi: 10.3390/pathogens6020018.


The structural basis for inhibition of the classical and lectin complement pathways by S. aureus extracellular adherence protein.

Woehl JL, Ramyar KX, Katz BB, Walker JK, Geisbrecht BV.

Protein Sci. 2017 Aug;26(8):1595-1608. doi: 10.1002/pro.3195. Epub 2017 May 31.


Enantioselective Synthesis of Dilignol Model Compounds and Their Stereodiscrimination Study with a Dye-Decolorizing Peroxidase.

Huang G, Shrestha R, Jia K, Geisbrecht BV, Li P.

Org Lett. 2017 Apr 7;19(7):1820-1823. doi: 10.1021/acs.orglett.7b00587. Epub 2017 Mar 22.


Identification of C3b-Binding Small-Molecule Complement Inhibitors Using Cheminformatics.

Garcia BL, Skaff DA, Chatterjee A, Hanning A, Walker JK, Wyckoff GJ, Geisbrecht BV.

J Immunol. 2017 May 1;198(9):3705-3718. doi: 10.4049/jimmunol.1601932. Epub 2017 Mar 15.


Structural Implications for the Formation and Function of the Complement Effector Protein iC3b.

Papanastasiou M, Koutsogiannaki S, Sarigiannis Y, Geisbrecht BV, Ricklin D, Lambris JD.

J Immunol. 2017 Apr 15;198(8):3326-3335. doi: 10.4049/jimmunol.1601864. Epub 2017 Mar 3.


Novel Evasion Mechanisms of the Classical Complement Pathway.

Garcia BL, Zwarthoff SA, Rooijakkers SH, Geisbrecht BV.

J Immunol. 2016 Sep 15;197(6):2051-60. doi: 10.4049/jimmunol.1600863. Review.

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