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Items: 1 to 20 of 63


Guinea pig transferrin receptor 1 mediates cellular entry of Junín virus and other pathogenic New World arenaviruses.

Hickerson BT, Westover JB, Wang Z, Lee YM, Gowen BB.

J Virol. 2019 Nov 20. pii: JVI.01278-19. doi: 10.1128/JVI.01278-19. [Epub ahead of print]


Vascular Leak and Hypercytokinemia Associated with Severe Fever with Thrombocytopenia Syndrome Virus Infection in Mice.

Westover JB, Hickerson BT, Van Wettere AJ, Hurst BL, Kurz JP, Dagley A, Wülfroth P, Komeno T, Furuta Y, Steiner T, Gowen BB.

Pathogens. 2019 Sep 21;8(4). pii: E158. doi: 10.3390/pathogens8040158.


A potent Lassa virus antiviral targets an arenavirus virulence determinant.

Madu IG, Files M, Gharaibeh DN, Moore AL, Jung KH, Gowen BB, Dai D, Jones KF, Tyavanagimatt SR, Burgeson JR, Korth MJ, Bedard KM, Iadonato SP, Amberg SM.

PLoS Pathog. 2018 Dec 21;14(12):e1007439. doi: 10.1371/journal.ppat.1007439. eCollection 2018 Dec.


Pathogenesis of Rift Valley Fever Virus Aerosol Infection in STAT2 Knockout Hamsters.

Hickerson BT, Westover JB, Van Wettere AJ, Rigas JD, Miao J, Conrad BL, Motter NE, Wang Z, Gowen BB.

Viruses. 2018 Nov 19;10(11). pii: E651. doi: 10.3390/v10110651.


2'-Fluoro-2'-deoxycytidine is a broad-spectrum inhibitor of bunyaviruses in vitro and in phleboviral disease mouse models.

Smee DF, Jung KH, Westover J, Gowen BB.

Antiviral Res. 2018 Dec;160:48-54. doi: 10.1016/j.antiviral.2018.10.013. Epub 2018 Oct 16.


Natural History and Pathogenesis of Wild-Type Marburg Virus Infection in STAT2 Knockout Hamsters.

Atkins C, Miao J, Kalveram B, Juelich T, Smith JK, Perez D, Zhang L, Westover JLB, Van Wettere AJ, Gowen BB, Wang Z, Freiberg AN.

J Infect Dis. 2018 Nov 22;218(suppl_5):S438-S447. doi: 10.1093/infdis/jiy457.


Favipiravir (T-705) but not ribavirin is effective against two distinct strains of Crimean-Congo hemorrhagic fever virus in mice.

Hawman DW, Haddock E, Meade-White K, Williamson B, Hanley PW, Rosenke K, Komeno T, Furuta Y, Gowen BB, Feldmann H.

Antiviral Res. 2018 Sep;157:18-26. doi: 10.1016/j.antiviral.2018.06.013. Epub 2018 Jun 21.


Use of Favipiravir to Treat Lassa Virus Infection in Macaques.

Rosenke K, Feldmann H, Westover JB, Hanley PW, Martellaro C, Feldmann F, Saturday G, Lovaglio J, Scott DP, Furuta Y, Komeno T, Gowen BB, Safronetz D.

Emerg Infect Dis. 2018 Sep;24(9):1696-1699. doi: 10.3201/eid2409.180233. Epub 2018 Sep 17.


Galidesivir limits Rift Valley fever virus infection and disease in Syrian golden hamsters.

Westover JB, Mathis A, Taylor R, Wandersee L, Bailey KW, Sefing EJ, Hickerson BT, Jung KH, Sheridan WP, Gowen BB.

Antiviral Res. 2018 Aug;156:38-45. doi: 10.1016/j.antiviral.2018.05.013. Epub 2018 Jun 1.


Effective Treatment of Experimental Lymphocytic Choriomeningitis Virus Infection: Consideration of Favipiravir for Use With Infected Organ Transplant Recipients.

Hickerson BT, Westover JB, Jung KH, Komeno T, Furuta Y, Gowen BB.

J Infect Dis. 2018 Jul 13;218(4):522-527. doi: 10.1093/infdis/jiy159.


Heartland virus infection in hamsters deficient in type I interferon signaling: Protracted disease course ameliorated by favipiravir.

Westover JB, Rigas JD, Van Wettere AJ, Li R, Hickerson BT, Jung KH, Miao J, Reynolds ES, Conrad BL, Nielson S, Furuta Y, Thangamani S, Wang Z, Gowen BB.

Virology. 2017 Nov;511:175-183. doi: 10.1016/j.virol.2017.08.004. Epub 2017 Aug 31.


Enhanced protection against experimental Junin virus infection through the use of a modified favipiravir loading dose strategy.

Gowen BB, Westover JB, Sefing EJ, Van Wettere AJ, Bailey KW, Wandersee L, Komeno T, Furuta Y.

Antiviral Res. 2017 Sep;145:131-135. doi: 10.1016/j.antiviral.2017.07.019. Epub 2017 Aug 2.


Hemorrhagic fever of bunyavirus etiology: disease models and progress towards new therapies.

Gowen BB, Hickerson BT.

J Microbiol. 2017 Mar;55(3):183-195. doi: 10.1007/s12275-017-7029-8. Epub 2017 Feb 28. Review.


Modeling Severe Fever with Thrombocytopenia Syndrome Virus Infection in Golden Syrian Hamsters: Importance of STAT2 in Preventing Disease and Effective Treatment with Favipiravir.

Gowen BB, Westover JB, Miao J, Van Wettere AJ, Rigas JD, Hickerson BT, Jung KH, Li R, Conrad BL, Nielson S, Furuta Y, Wang Z.

J Virol. 2017 Jan 18;91(3). pii: e01942-16. doi: 10.1128/JVI.01942-16. Print 2017 Feb 1.


Low-dose ribavirin potentiates the antiviral activity of favipiravir against hemorrhagic fever viruses.

Westover JB, Sefing EJ, Bailey KW, Van Wettere AJ, Jung KH, Dagley A, Wandersee L, Downs B, Smee DF, Furuta Y, Bray M, Gowen BB.

Antiviral Res. 2016 Feb;126:62-8. doi: 10.1016/j.antiviral.2015.12.006. Epub 2015 Dec 19.


The broad-spectrum antiviral favipiravir protects guinea pigs from lethal Lassa virus infection post-disease onset.

Safronetz D, Rosenke K, Westover JB, Martellaro C, Okumura A, Furuta Y, Geisbert J, Saturday G, Komeno T, Geisbert TW, Feldmann H, Gowen BB.

Sci Rep. 2015 Oct 12;5:14775. doi: 10.1038/srep14775.


Alterations in favipiravir (T-705) pharmacokinetics and biodistribution in a hamster model of viral hemorrhagic fever.

Gowen BB, Sefing EJ, Westover JB, Smee DF, Hagloch J, Furuta Y, Hall JO.

Antiviral Res. 2015 Sep;121:132-7. doi: 10.1016/j.antiviral.2015.07.003. Epub 2015 Jul 14.


MP-12 virus containing the clone 13 deletion in the NSs gene prevents lethal disease when administered after Rift Valley fever virus infection in hamsters.

Gowen BB, Westover JB, Sefing EJ, Bailey KW, Nishiyama S, Wandersee L, Scharton D, Jung KH, Ikegami T.

Front Microbiol. 2015 Jun 29;6:651. doi: 10.3389/fmicb.2015.00651. eCollection 2015.


Rift Valley fever virus infection in golden Syrian hamsters.

Scharton D, Van Wettere AJ, Bailey KW, Vest Z, Westover JB, Siddharthan V, Gowen BB.

PLoS One. 2015 Jan 21;10(1):e0116722. doi: 10.1371/journal.pone.0116722. eCollection 2015.


Characterization of the host response to pichinde virus infection in the Syrian golden hamster by species-specific kinome analysis.

Falcinelli S, Gowen BB, Trost B, Napper S, Kusalik A, Johnson RF, Safronetz D, Prescott J, Wahl-Jensen V, Jahrling PB, Kindrachuk J.

Mol Cell Proteomics. 2015 Mar;14(3):646-57. doi: 10.1074/mcp.M114.045443. Epub 2015 Jan 8.

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