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Items: 1 to 20 of 74

1.

New chalcone-sulfonamide hybrids exhibiting anticancer and antituberculosis activity.

Castaño LF, Cuartas V, Bernal A, Insuasty A, Guzman J, Vidal O, Rubio V, Puerto G, Lukáč P, Vimberg V, Balíková-Novtoná G, Vannucci L, Janata J, Quiroga J, Abonia R, Nogueras M, Cobo J, Insuasty B.

Eur J Med Chem. 2019 Aug 15;176:50-60. doi: 10.1016/j.ejmech.2019.05.013. Epub 2019 May 7.

PMID:
31096118
2.

Catalyst-free assembly of giant tris(heteroaryl)methanes: synthesis of novel pharmacophoric triads and model sterically crowded tris(heteroaryl/aryl)methyl cation salts.

Abonia R, Gutiérrez LF, Insuasty B, Quiroga J, Laali KK, Zhao C, Borosky GL, Horwitz SM, Bunge SD.

Beilstein J Org Chem. 2019 Mar 12;15:642-654. doi: 10.3762/bjoc.15.60. eCollection 2019.

3.

Synthesis of New 1,3,5-Triazine-Based 2-Pyrazolines as Potential Anticancer Agents.

Moreno LM, Quiroga J, Abonia R, Ramírez-Prada J, Insuasty B.

Molecules. 2018 Aug 6;23(8). pii: E1956. doi: 10.3390/molecules23081956.

4.

Design, facile synthesis, and evaluation of novel spiro- and pyrazolo[1,5-c]quinazolines as cholinesterase inhibitors: Molecular docking and MM/GBSA studies.

Gálvez J, Polo S, Insuasty B, Gutiérrez M, Cáceres D, Alzate-Morales JH, De-la-Torre P, Quiroga J.

Comput Biol Chem. 2018 Jun;74:218-229. doi: 10.1016/j.compbiolchem.2018.03.001. Epub 2018 Mar 7.

PMID:
29655025
5.

Design of Two Alternative Routes for the Synthesis of Naftifine and Analogues as Potential Antifungal Agents.

Abonia R, Garay A, Castillo JC, Insuasty B, Quiroga J, Nogueras M, Cobo J, Butassi E, Zacchino S.

Molecules. 2018 Feb 26;23(3). pii: E520. doi: 10.3390/molecules23030520.

6.

In Silico and in Vitro-Guided Identification of Inhibitors of Alkylquinolone-Dependent Quorum Sensing in Pseudomonas aeruginosa.

Soukarieh F, Vico Oton E, Dubern JF, Gomes J, Halliday N, de Pilar Crespo M, Ramírez-Prada J, Insuasty B, Abonia R, Quiroga J, Heeb S, Williams P, Stocks MJ, Cámara M.

Molecules. 2018 Jan 28;23(2). pii: E257. doi: 10.3390/molecules23020257.

7.

Synthesis and DFT Calculations of Novel Vanillin-Chalcones and Their 3-Aryl-5-(4-(2-(dimethylamino)-ethoxy)-3-methoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbaldehyde Derivatives as Antifungal Agents.

Illicachi LA, Montalvo-Acosta JJ, Insuasty A, Quiroga J, Abonia R, Sortino M, Zacchino S, Insuasty B.

Molecules. 2017 Sep 5;22(9). pii: E1476. doi: 10.3390/molecules22091476.

8.

A Schmidt rearrangement-mediated synthesis of novel tetrahydro-benzo[1,4]diazepin-5-ones as potential anticancer and antiprotozoal agents.

Insuasty D, Robledo SM, Vélez ID, Cuervo P, Insuasty B, Quiroga J, Nogueras M, Cobo J, Abonia R.

Eur J Med Chem. 2017 Dec 1;141:567-583. doi: 10.1016/j.ejmech.2017.10.024. Epub 2017 Oct 10.

PMID:
29102177
9.

Reduced 3,4'-bipyrazoles from a simple pyrazole precursor: synthetic sequence, molecular structures and supramolecular assembly.

Cuartas V, Insuasty B, Cobo J, Glidewell C.

Acta Crystallogr C Struct Chem. 2017 Oct 1;73(Pt 10):784-790. doi: 10.1107/S205322961701302X. Epub 2017 Sep 20.

PMID:
28978784
10.

Synthesis of novel 7-aryl and 7-spiropyrazolo[4',3':5,6]pyrido[2,3-d]pyrimidine derivatives and their study as AChE inhibitors.

Acosta P, Insuasty B, Abonia R, Gutierrez M, Quiroga J.

Mol Divers. 2017 Nov;21(4):943-955. doi: 10.1007/s11030-017-9774-3. Epub 2017 Aug 7.

PMID:
28785929
11.

Microwave-Assisted Synthesis of Diversely Substituted Quinoline-Based Dihydropyridopyrimidine and Dihydropyrazolopyridine Hybrids.

Insuasty D, Abonia R, Insuasty B, Quiroga J, Laali KK, Nogueras M, Cobo J.

ACS Comb Sci. 2017 Aug 14;19(8):555-563. doi: 10.1021/acscombsci.7b00091. Epub 2017 Jul 26.

PMID:
28723092
12.

Synthesis of novel quinoline-based 4,5-dihydro-1H-pyrazoles as potential anticancer, antifungal, antibacterial and antiprotozoal agents.

Ramírez-Prada J, Robledo SM, Vélez ID, Crespo MDP, Quiroga J, Abonia R, Montoya A, Svetaz L, Zacchino S, Insuasty B.

Eur J Med Chem. 2017 May 5;131:237-254. doi: 10.1016/j.ejmech.2017.03.016. Epub 2017 Mar 16.

PMID:
28329730
13.

Synthesis and Antifungal in Vitro Evaluation of Pyrazolo[3,4-b]pyridines Derivatives Obtained by Aza-Diels-Alder Reaction and Microwave Irradiation.

Quiroga J, Villarreal Y, Gálvez J, Ortíz A, Insuasty B, Abonia R, Raimondi M, Zacchino S.

Chem Pharm Bull (Tokyo). 2017 Feb 1;65(2):143-150. doi: 10.1248/cpb.c16-00652. Epub 2016 Nov 25.

14.

Hybrid Molecules Containing a 7-Chloro-4-aminoquinoline Nucleus and a Substituted 2-Pyrazoline with Antiproliferative and Antifungal Activity.

Montoya A, Quiroga J, Abonia R, Derita M, Sortino M, Ornelas A, Zacchino S, Insuasty B.

Molecules. 2016 Jul 27;21(8). pii: E969. doi: 10.3390/molecules21080969.

15.

On-off switch of charge-separated states of pyridine-vinylene-linked porphyrin-C60 conjugates detected by EPR.

Kirner SV, Arteaga D, Henkel C, Margraf JT, Alegret N, Ohkubo K, Insuasty B, Ortiz A, Martín N, Echegoyen L, Fukuzumi S, Clark T, Guldi DM.

Chem Sci. 2015 Oct 1;6(10):5994-6007. doi: 10.1039/c5sc02051d. Epub 2015 Jul 9.

16.

Microwave-Assisted Synthesis of Novel Pyrazolo[3,4-g][1,8]naphthyridin-5-amine with Potential Antifungal and Antitumor Activity.

Acosta P, Butassi E, Insuasty B, Ortiz A, Abonia R, Zacchino SA, Quiroga J.

Molecules. 2015 May 12;20(5):8499-520. doi: 10.3390/molecules20058499.

17.

An efficient synthesis of new caffeine-based chalcones, pyrazolines and pyrazolo[3,4-b][1,4]diazepines as potential antimalarial, antitrypanosomal and antileishmanial agents.

Insuasty B, Ramírez J, Becerra D, Echeverry C, Quiroga J, Abonia R, Robledo SM, Vélez ID, Upegui Y, Muñoz JA, Ospina V, Nogueras M, Cobo J.

Eur J Med Chem. 2015 Mar 26;93:401-13. doi: 10.1016/j.ejmech.2015.02.040. Epub 2015 Feb 21.

PMID:
25725376
18.

Synthesis of novel thiazole-based 8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepines as potential antitumor and antifungal agents.

Ramírez J, Svetaz L, Quiroga J, Abonia R, Raimondi M, Zacchino S, Insuasty B.

Eur J Med Chem. 2015 Mar 6;92:866-75. doi: 10.1016/j.ejmech.2015.01.053. Epub 2015 Jan 26.

PMID:
25638570
19.

Synthesis and in vitro antitumor activity of a novel series of 2-pyrazoline derivatives bearing the 4-aryloxy-7-chloroquinoline fragment.

Montoya A, Quiroga J, Abonia R, Nogueras M, Cobo J, Insuasty B.

Molecules. 2014 Nov 14;19(11):18656-75. doi: 10.3390/molecules191118656.

20.

2-Ethyl-1-[5-(4-methylphenyl)pyrazol-3-yl]-3-(thiophene-2-carbonyl)isothiourea: molecular ribbons containing three types of hydrogen-bonded ring.

Castro E, Insuasty H, Insuasty B, Cobo J, Glidewell C.

Acta Crystallogr C Struct Chem. 2014 Nov;70(Pt 11):1064-8. doi: 10.1107/S205322961402244X. Epub 2014 Oct 17.

PMID:
25370108

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