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Molecules. 2017 Sep 7;22(9). pii: E1475. doi: 10.3390/molecules22091475.

Cyclodextrin-Catalyzed Organic Synthesis: Reactions, Mechanisms, and Applications.

Author information

1
School of Pharmacy, Ningxia Medical University, Yinchuan 750004, China. changcaibai@163.com.
2
School of Pharmacy, Ningxia Medical University, Yinchuan 750004, China. tianbingren1@163.com.
3
School of Pharmacy, Ningxia Medical University, Yinchuan 750004, China. ZhaoTian7283@163.com.
4
School of Pharmacy, Ningxia Medical University, Yinchuan 750004, China. hq82@163.com.
5
Key Laboratory of Hui Ethnic Medicine Modernization, Ministry of Education, Yinchuan 750004, China. hq82@163.com.
6
School of Pharmacy, Ningxia Medical University, Yinchuan 750004, China. wangzzsc@163.com.
7
Key Laboratory of Hui Ethnic Medicine Modernization, Ministry of Education, Yinchuan 750004, China. wangzzsc@163.com.

Abstract

Cyclodextrins are well-known macrocyclic oligosaccharides that consist of α-(1,4) linked glucose units and have been widely used as artificial enzymes, chiral separators, chemical sensors, and drug excipients, owing to their hydrophobic and chiral interiors. Due to their remarkable inclusion capabilities with small organic molecules, more recent interests focus on organic reactions catalyzed by cyclodextrins. This contribution outlines the current progress in cyclodextrin-catalyzed organic reactions. Particular emphases are given to the organic reaction mechanisms and their applications. In the end, the future directions of research in this field are proposed.

KEYWORDS:

asymmetric reaction; catalysis; cyclodextrin; green chemistry; mechanism; organic reaction

PMID:
28880241
DOI:
10.3390/molecules22091475
[Indexed for MEDLINE]
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