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Items: 1 to 20 of 167

1.

TLR9 and beclin 1 crosstalk regulates muscle AMPK activation in exercise.

Liu Y, Nguyen PT, Wang X, Zhao Y, Meacham CE, Zou Z, Bordieanu B, Johanns M, Vertommen D, Wijshake T, May H, Xiao G, Shoji-Kawata S, Rider MH, Morrison SJ, Mishra P, Levine B.

Nature. 2020 Feb;578(7796):605-609. doi: 10.1038/s41586-020-1992-7. Epub 2020 Feb 12.

PMID:
32051584
2.

Interaction between the autophagy protein Beclin 1 and Na+,K+-ATPase during starvation, exercise, and ischemia.

Fernández ÁF, Liu Y, Ginet V, Shi M, Nah J, Zou Z, Zhou A, Posner BA, Xiao G, Tanguy M, Paradis V, Sadoshima J, Rautou PE, Puyal J, Hu MC, Levine B.

JCI Insight. 2020 Jan 16;5(1). pii: 133282. doi: 10.1172/jci.insight.133282.

3.

The tripartite interaction of phosphate, autophagy, and αKlotho in health maintenance.

Shi M, Maique J, Shaffer J, Davidson T, Sebti S, Fernández ÁF, Zou Z, Yan S, Levine B, Moe OW, Hu MC.

FASEB J. 2020 Feb;34(2):3129-3150. doi: 10.1096/fj.201902127R. Epub 2020 Jan 5.

PMID:
31908069
4.
5.

Protective Effect of SMAD-Specific E3 Ubiquitin Protein Ligase 1 in Alcoholic Steatohepatitis in Mice.

Petrasek J, Erhartova D, Levine B.

Hepatol Commun. 2019 Sep 12;3(11):1450-1458. doi: 10.1002/hep4.1427. eCollection 2019 Nov.

6.

SOD1-positive aggregate accumulation in the CNS predicts slower disease progression and increased longevity in a mutant SOD1 mouse model of ALS.

Gill C, Phelan JP, Hatzipetros T, Kidd JD, Tassinari VR, Levine B, Wang MZ, Moreno A, Thompson K, Maier M, Grimm J, Gill A, Vieira FG.

Sci Rep. 2019 Apr 30;9(1):6724. doi: 10.1038/s41598-019-43164-z.

7.

Biological Functions of Autophagy Genes: A Disease Perspective.

Levine B, Kroemer G.

Cell. 2019 Jan 10;176(1-2):11-42. doi: 10.1016/j.cell.2018.09.048. Review.

8.

Autophagy and the cell biology of age-related disease.

Leidal AM, Levine B, Debnath J.

Nat Cell Biol. 2018 Dec;20(12):1338-1348. doi: 10.1038/s41556-018-0235-8. Epub 2018 Nov 26. Review.

PMID:
30482941
9.

Cell Penetration Profiling Using the Chloroalkane Penetration Assay.

Peraro L, Deprey KL, Moser MK, Zou Z, Ball HL, Levine B, Kritzer JA.

J Am Chem Soc. 2018 Sep 12;140(36):11360-11369. doi: 10.1021/jacs.8b06144. Epub 2018 Aug 31.

10.

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing.

Boland B, Yu WH, Corti O, Mollereau B, Henriques A, Bezard E, Pastores GM, Rubinsztein DC, Nixon RA, Duchen MR, Mallucci GR, Kroemer G, Levine B, Eskelinen EL, Mochel F, Spedding M, Louis C, Martin OR, Millan MJ.

Nat Rev Drug Discov. 2018 Sep;17(9):660-688. doi: 10.1038/nrd.2018.109. Epub 2018 Aug 17. Review.

11.

Author Correction: Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice.

Fernández ÁF, Sebti S, Wei Y, Zou Z, Shi M, McMillan KL, He C, Ting T, Liu Y, Chiang WC, Marciano DK, Schiattarella GG, Bhagat G, Moe OW, Hu MC, Levine B.

Nature. 2018 Sep;561(7723):E30. doi: 10.1038/s41586-018-0270-4.

PMID:
29921925
12.

High-Throughput Screens To Identify Autophagy Inducers That Function by Disrupting Beclin 1/Bcl-2 Binding.

Chiang WC, Wei Y, Kuo YC, Wei S, Zhou A, Zou Z, Yehl J, Ranaghan MJ, Skepner A, Bittker JA, Perez JR, Posner BA, Levine B.

ACS Chem Biol. 2018 Aug 17;13(8):2247-2260. doi: 10.1021/acschembio.8b00421. Epub 2018 Jun 21.

13.

An increase in LRRK2 suppresses autophagy and enhances Dectin-1-induced immunity in a mouse model of colitis.

Takagawa T, Kitani A, Fuss I, Levine B, Brant SR, Peter I, Tajima M, Nakamura S, Strober W.

Sci Transl Med. 2018 Jun 6;10(444). pii: eaan8162. doi: 10.1126/scitranslmed.aan8162.

14.

Beclin-1-Dependent Autophagy Protects the Heart During Sepsis.

Sun Y, Yao X, Zhang QJ, Zhu M, Liu ZP, Ci B, Xie Y, Carlson D, Rothermel BA, Sun Y, Levine B, Hill JA, Wolf SE, Minei JP, Zang QS.

Circulation. 2018 Nov 13;138(20):2247-2262. doi: 10.1161/CIRCULATIONAHA.117.032821.

15.

Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice.

Fernández ÁF, Sebti S, Wei Y, Zou Z, Shi M, McMillan KL, He C, Ting T, Liu Y, Chiang WC, Marciano DK, Schiattarella GG, Bhagat G, Moe OW, Hu MC, Levine B.

Nature. 2018 Jun;558(7708):136-140. doi: 10.1038/s41586-018-0162-7. Epub 2018 May 30. Erratum in: Nature. 2018 Sep;561(7723):E30.

16.

Increased autophagy blocks HER2-mediated breast tumorigenesis.

Vega-Rubín-de-Celis S, Zou Z, Fernández ÁF, Ci B, Kim M, Xiao G, Xie Y, Levine B.

Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):4176-4181. doi: 10.1073/pnas.1717800115. Epub 2018 Apr 2.

17.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G.

Cell Death Differ. 2018 Mar;25(3):486-541. doi: 10.1038/s41418-017-0012-4. Epub 2018 Jan 23. Review.

18.

Loss of Paneth Cell Autophagy Causes Acute Susceptibility to Toxoplasma gondii-Mediated Inflammation.

Burger E, Araujo A, López-Yglesias A, Rajala MW, Geng L, Levine B, Hooper LV, Burstein E, Yarovinsky F.

Cell Host Microbe. 2018 Feb 14;23(2):177-190.e4. doi: 10.1016/j.chom.2018.01.001. Epub 2018 Jan 18.

19.

The Autophagy-Related Beclin-1 Protein Requires the Coiled-Coil and BARA Domains To Form a Homodimer with Submicromolar Affinity.

Ranaghan MJ, Durney MA, Mesleh MF, McCarren PR, Garvie CW, Daniels DS, Carey KL, Skepner AP, Levine B, Perez JR.

Biochemistry. 2017 Dec 26;56(51):6639-6651. doi: 10.1021/acs.biochem.7b00936. Epub 2017 Dec 14.

20.

Autophagy balances inflammation in innate immunity.

Deretic V, Levine B.

Autophagy. 2018;14(2):243-251. doi: 10.1080/15548627.2017.1402992. Epub 2018 Jan 17. Review.

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