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Items: 1 to 20 of 236

1.

Critical redundant functions of the adapters Grb2 and Gads in platelet (hem)ITAM signaling in mice.

Vögtle T, Baig AA, Volz J, Duchow TB, Pleines I, Dütting S, Nitschke L, Watson SP, Nieswandt B.

Platelets. 2020 Jan 16:1-11. doi: 10.1080/09537104.2019.1709633. [Epub ahead of print]

PMID:
31948362
2.

Local Leukocyte Invasion during Hyperacute Human Ischemic Stroke.

Kollikowski AM, Schuhmann MK, Nieswandt B, Müllges W, Stoll G, Pham M.

Ann Neurol. 2020 Jan 3. doi: 10.1002/ana.25665. [Epub ahead of print]

PMID:
31899551
3.

Platelets as Modulators of Cerebral Ischemia/Reperfusion Injury.

Stegner D, Klaus V, Nieswandt B.

Front Immunol. 2019 Nov 1;10:2505. doi: 10.3389/fimmu.2019.02505. eCollection 2019. Review.

4.

Platelet lamellipodium formation is not required for thrombus formation and stability.

Schurr Y, Sperr A, Volz J, Beck S, Reil L, Kusch C, Eiring P, Bryson S, Sauer M, Nieswandt B, Machesky L, Bender M.

Blood. 2019 Dec 19;134(25):2318-2329. doi: 10.1182/blood.2019002105.

PMID:
31697813
5.

Interspecies differences in protein expression do not impact the spatiotemporal regulation of glycoprotein VI mediated activation.

Dunster JL, Unsworth AJ, Bye AP, Haining EJ, Sowa MA, Di Y, Sage T, Pallini C, Pike JA, Hardy AT, Nieswandt B, García Á, Watson SP, Poulter NS, Gibbins JM, Pollitt AY.

J Thromb Haemost. 2019 Nov 4. doi: 10.1111/jth.14673. [Epub ahead of print]

PMID:
31680418
6.

Coactosin-like 1 integrates signaling critical for shear-dependent thrombus formation in mouse platelets.

Scheller I, Stritt S, Beck S, Peng B, Pleines I, Heinze KG, Braun A, Otto O, Ahrends R, Sickmann A, Bender M, Nieswandt B.

Haematologica. 2019 Oct 3. pii: haematol.2019.225516. doi: 10.3324/haematol.2019.225516. [Epub ahead of print]

7.

Pivotal role of PDK1 in megakaryocyte cytoskeletal dynamics and polarization during platelet biogenesis.

Geue S, Aurbach K, Manke MC, Manukjan G, Münzer P, Stegner D, Brähler C, Walker-Allgaier B, Märklin M, Borst CE, Quintanilla-Fend L, Rath D, Geisler T, Salih HR, Seizer P, Lang F, Nieswandt B, Gawaz M, Schulze H, Pleines I, Borst O.

Blood. 2019 Nov 21;134(21):1847-1858. doi: 10.1182/blood.2019000185.

PMID:
31578203
8.

Loss of Orai2-Mediated Capacitative Ca2+ Entry Is Neuroprotective in Acute Ischemic Stroke.

Stegner D, Hofmann S, Schuhmann MK, Kraft P, Herrmann AM, Popp S, Höhn M, Popp M, Klaus V, Post A, Kleinschnitz C, Braun A, Meuth SG, Lesch KP, Stoll G, Kraft R, Nieswandt B.

Stroke. 2019 Nov;50(11):3238-3245. doi: 10.1161/STROKEAHA.119.025357. Epub 2019 Sep 25.

PMID:
31551038
9.

Genetic platelet depletion is superior in platelet transfusion compared to current models.

Salzmann M, Schrottmaier WC, Kral-Pointner JB, Mussbacher M, Volz J, Hoesel B, Moser B, Bleichert S, Morava S, Nieswandt B, Schmid JA, Assinger A.

Haematologica. 2019 Sep 19. pii: haematol.2019.222448. doi: 10.3324/haematol.2019.222448. [Epub ahead of print]

10.

Comparative Analysis of Microfluidics Thrombus Formation in Multiple Genetically Modified Mice: Link to Thrombosis and Hemostasis.

Nagy M, van Geffen JP, Stegner D, Adams DJ, Braun A, de Witt SM, Elvers M, Geer MJ, Kuijpers MJE, Kunzelmann K, Mori J, Oury C, Pircher J, Pleines I, Poole AW, Senis YA, Verdoold R, Weber C, Nieswandt B, Heemskerk JWM, Baaten CCFMJ.

Front Cardiovasc Med. 2019 Jul 30;6:99. doi: 10.3389/fcvm.2019.00099. eCollection 2019.

11.

Thrombo-inflammation in acute ischaemic stroke - implications for treatment.

Stoll G, Nieswandt B.

Nat Rev Neurol. 2019 Aug;15(8):473-481. doi: 10.1038/s41582-019-0221-1. Epub 2019 Jul 1. Review.

PMID:
31263257
12.

Defective Zn2+ homeostasis in mouse and human platelets with α- and δ-storage pool diseases.

Kiran Gotru S, van Geffen JP, Nagy M, Mammadova-Bach E, Eilenberger J, Volz J, Manukjan G, Schulze H, Wagner L, Eber S, Schambeck C, Deppermann C, Brouns S, Nurden P, Greinacher A, Sachs U, Nieswandt B, Hermanns HM, Heemskerk JWM, Braun A.

Sci Rep. 2019 Jun 6;9(1):8333. doi: 10.1038/s41598-019-44751-w.

13.

Identification of a Clinically Relevant Signature for Early Progression in KRAS-Driven Lung Adenocarcinoma.

Neidler S, Kruspig B, Hewit K, Monteverde T, Gyuraszova K, Braun A, Clark W, James D, Hedley A, Nieswandt B, Shanks E, Dick C, Murphy DJ.

Cancers (Basel). 2019 Apr 29;11(5). pii: E600. doi: 10.3390/cancers11050600.

14.

Targeting Platelet GPVI Plus rt-PA Administration but Not α2β1-Mediated Collagen Binding Protects against Ischemic Brain Damage in Mice.

Schuhmann MK, Kraft P, Bieber M, Kollikowski AM, Schulze H, Nieswandt B, Pham M, Stegner D, Stoll G.

Int J Mol Sci. 2019 Apr 24;20(8). pii: E2019. doi: 10.3390/ijms20082019.

15.

Inhibition of platelet GPVI induces intratumor hemorrhage and increases efficacy of chemotherapy in mice.

Volz J, Mammadova-Bach E, Gil-Pulido J, Nandigama R, Remer K, Sorokin L, Zernecke A, Abrams SI, Ergün S, Henke E, Nieswandt B.

Blood. 2019 Jun 20;133(25):2696-2706. doi: 10.1182/blood.2018877043. Epub 2019 Apr 5.

PMID:
30952674
16.

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer.

Malehmir M, Pfister D, Gallage S, Szydlowska M, Inverso D, Kotsiliti E, Leone V, Peiseler M, Surewaard BGJ, Rath D, Ali A, Wolf MJ, Drescher H, Healy ME, Dauch D, Kroy D, Krenkel O, Kohlhepp M, Engleitner T, Olkus A, Sijmonsma T, Volz J, Deppermann C, Stegner D, Helbling P, Nombela-Arrieta C, Rafiei A, Hinterleitner M, Rall M, Baku F, Borst O, Wilson CL, Leslie J, O'Connor T, Weston CJ, Adams DH, Sheriff L, Teijeiro A, Prinz M, Bogeska R, Anstee N, Bongers MN, Notohamiprodjo M, Geisler T, Withers DJ, Ware J, Mann DA, Augustin HG, Vegiopoulos A, Milsom MD, Rose AJ, Lalor PF, Llovet JM, Pinyol R, Tacke F, Rad R, Matter M, Djouder N, Kubes P, Knolle PA, Unger K, Zender L, Nieswandt B, Gawaz M, Weber A, Heikenwalder M.

Nat Med. 2019 Apr;25(4):641-655. doi: 10.1038/s41591-019-0379-5. Epub 2019 Apr 1.

17.

Functional significance of the platelet immune receptors GPVI and CLEC-2.

Rayes J, Watson SP, Nieswandt B.

J Clin Invest. 2019 Jan 2;129(1):12-23. doi: 10.1172/JCI122955. Epub 2019 Jan 2. Review.

18.

Tspan18 is a novel regulator of the Ca2+ channel Orai1 and von Willebrand factor release in endothelial cells.

Noy PJ, Gavin RL, Colombo D, Haining EJ, Reyat JS, Payne H, Thielmann I, Lokman AB, Neag G, Yang J, Lloyd T, Harrison N, Heath VL, Gardiner C, Whitworth KM, Robinson J, Koo CZ, Di Maio A, Harrison P, Lee SP, Michelangeli F, Kalia N, Rainger GE, Nieswandt B, Brill A, Watson SP, Tomlinson MG.

Haematologica. 2019 Sep;104(9):1892-1905. doi: 10.3324/haematol.2018.194241. Epub 2018 Dec 20.

19.

Description of a Novel Phosphodiesterase (PDE)-3 Inhibitor Protecting Mice From Ischemic Stroke Independent From Platelet Function.

Bieber M, Schuhmann MK, Volz J, Kumar GJ, Vaidya JR, Nieswandt B, Pham M, Stoll G, Kleinschnitz C, Kraft P.

Stroke. 2019 Feb;50(2):478-486. doi: 10.1161/STROKEAHA.118.023664.

20.

Store-operated calcium entry in thrombosis and thrombo-inflammation.

Mammadova-Bach E, Nagy M, Heemskerk JWM, Nieswandt B, Braun A.

Cell Calcium. 2019 Jan;77:39-48. doi: 10.1016/j.ceca.2018.11.005. Epub 2018 Nov 23. Review.

PMID:
30530092

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