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Items: 20


Class III PI3K Vps34 Controls Thyroid Hormone Production by Regulating Thyroglobulin Iodination, Lysosomal Proteolysis, and Tissue Homeostasis.

Grieco G, Wang T, Delcorte O, Spourquet C, Janssens V, Strickaert A, Gaide Chevronnay HP, Liao XH, Bilanges B, Refetoff S, Vanhaesebroeck B, Maenhaut C, Courtoy PJ, Pierreux CE.

Thyroid. 2020 Jan;30(1):133-146. doi: 10.1089/thy.2019.0182. Epub 2019 Dec 2.


Perspective: Potential Impact and Therapeutic Implications of Oncogenic PI3K Activation on Chromosomal Instability.

Vanhaesebroeck B, Bilanges B, Madsen RR, Dale KL, Lau E, Vladimirou E.

Biomolecules. 2019 Aug 1;9(8). pii: E331. doi: 10.3390/biom9080331. Review.


PI3K isoforms in cell signalling and vesicle trafficking.

Bilanges B, Posor Y, Vanhaesebroeck B.

Nat Rev Mol Cell Biol. 2019 Sep;20(9):515-534. doi: 10.1038/s41580-019-0129-z. Review.


Vps34/PI3KC3 deletion in kidney proximal tubules impairs apical trafficking and blocks autophagic flux, causing a Fanconi-like syndrome and renal insufficiency.

Grieco G, Janssens V, Gaide Chevronnay HP, N'Kuli F, Van Der Smissen P, Wang T, Shan J, Vainio S, Bilanges B, Jouret F, Vanhaesebroeck B, Pierreux CE, Courtoy PJ.

Sci Rep. 2018 Sep 20;8(1):14133. doi: 10.1038/s41598-018-32389-z.


Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism.

Bilanges B, Alliouachene S, Pearce W, Morelli D, Szabadkai G, Chung YL, Chicanne G, Valet C, Hill JM, Voshol PJ, Collinson L, Peddie C, Ali K, Ghazaly E, Rajeeve V, Trichas G, Srinivas S, Chaussade C, Salamon RS, Backer JM, Scudamore CL, Whitehead MA, Keaney EP, Murphy LO, Semple RK, Payrastre B, Tooze SA, Vanhaesebroeck B.

Nat Commun. 2017 Nov 27;8(1):1804. doi: 10.1038/s41467-017-01969-4.


Identification of Plagl1/Zac1 binding sites and target genes establishes its role in the regulation of extracellular matrix genes and the imprinted gene network.

Varrault A, Dantec C, Le Digarcher A, Chotard L, Bilanges B, Parrinello H, Dubois E, Rialle S, Severac D, Bouschet T, Journot L.

Nucleic Acids Res. 2017 Oct 13;45(18):10466-10480. doi: 10.1093/nar/gkx672.


A dual role for the class III PI3K, Vps34, in platelet production and thrombus growth.

Valet C, Levade M, Chicanne G, Bilanges B, Cabou C, Viaud J, Gratacap MP, Gaits-Iacovoni F, Vanhaesebroeck B, Payrastre B, Severin S.

Blood. 2017 Nov 2;130(18):2032-2042. doi: 10.1182/blood-2017-04-781641. Epub 2017 Sep 13.


Inactivation of class II PI3K-C2α induces leptin resistance, age-dependent insulin resistance and obesity in male mice.

Alliouachene S, Bilanges B, Chaussade C, Pearce W, Foukas LC, Scudamore CL, Moniz LS, Vanhaesebroeck B.

Diabetologia. 2016 Jul;59(7):1503-1512. doi: 10.1007/s00125-016-3963-y. Epub 2016 Apr 30.


Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity.

Alliouachene S, Bilanges B, Chicanne G, Anderson KE, Pearce W, Ali K, Valet C, Posor Y, Low PC, Chaussade C, Scudamore CL, Salamon RS, Backer JM, Stephens L, Hawkins PT, Payrastre B, Vanhaesebroeck B.

Cell Rep. 2015 Dec 1;13(9):1881-94. doi: 10.1016/j.celrep.2015.10.052. Epub 2015 Nov 19.


Cinderella finds her shoe: the first Vps34 inhibitor uncovers a new PI3K-AGC protein kinase connection.

Bilanges B, Vanhaesebroeck B.

Biochem J. 2014 Dec 1;464(2):e7-10. doi: 10.1042/BJ20141218.


Environmental stress affects the activity of metabolic and growth factor signaling networks and induces autophagy markers in MCF7 breast cancer cells.

Casado P, Bilanges B, Rajeeve V, Vanhaesebroeck B, Cutillas PR.

Mol Cell Proteomics. 2014 Mar;13(3):836-48. doi: 10.1074/mcp.M113.034751. Epub 2014 Jan 14.


Class III phosphoinositide 3-kinase/VPS34 and dynamin are critical for apical endocytic recycling.

Carpentier S, N'Kuli F, Grieco G, Van Der Smissen P, Janssens V, Emonard H, Bilanges B, Vanhaesebroeck B, Gaide Chevronnay HP, Pierreux CE, Tyteca D, Courtoy PJ.

Traffic. 2013 Aug;14(8):933-48. doi: 10.1111/tra.12079. Epub 2013 Jun 3.


Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism.

Foukas LC, Bilanges B, Bettedi L, Pearce W, Ali K, Sancho S, Withers DJ, Vanhaesebroeck B.

EMBO Mol Med. 2013 Apr;5(4):563-71. doi: 10.1002/emmm.201201953. Epub 2013 Mar 11.


A new tool to dissect the function of p70 S6 kinase.

Bilanges B, Vanhaesebroeck B.

Biochem J. 2010 Oct 15;431(2):e1-3. doi: 10.1042/BJ20101445.


The emerging mechanisms of isoform-specific PI3K signalling.

Vanhaesebroeck B, Guillermet-Guibert J, Graupera M, Bilanges B.

Nat Rev Mol Cell Biol. 2010 May;11(5):329-41. doi: 10.1038/nrm2882. Epub 2010 Apr 9. Review.


Killing two kinase families with one stone.

Bilanges B, Torbett N, Vanhaesebroeck B.

Nat Chem Biol. 2008 Nov;4(11):648-9. doi: 10.1038/nchembio1108-648. No abstract available.


Tuberous sclerosis complex proteins 1 and 2 control serum-dependent translation in a TOP-dependent and -independent manner.

Bilanges B, Argonza-Barrett R, Kolesnichenko M, Skinner C, Nair M, Chen M, Stokoe D.

Mol Cell Biol. 2007 Aug;27(16):5746-64. Epub 2007 Jun 11.


Translational deregulation in PDK-1-/- embryonic stem cells.

Tominaga Y, Tamgüney T, Kolesnichenko M, Bilanges B, Stokoe D.

Mol Cell Biol. 2005 Oct;25(19):8465-75.


Phosphorylation-independent stabilization of p27kip1 by the phosphoinositide 3-kinase pathway in glioblastoma cells.

Brandts CH, Bilanges B, Hare G, McCormick F, Stokoe D.

J Biol Chem. 2005 Jan 21;280(3):2012-9. Epub 2004 Nov 12.

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