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Items: 17


Antivenom Neutralization of Coagulopathic Snake Venom Toxins Assessed by Bioactivity Profiling Using Nanofractionation Analytics.

Xie C, Slagboom J, Albulescu LO, Bruyneel B, Still KBM, Vonk FJ, Somsen GW, Casewell NR, Kool J.

Toxins (Basel). 2020 Jan 16;12(1). pii: E53. doi: 10.3390/toxins12010053.


The role of metabolism in the developmental toxicity of polycyclic aromatic hydrocarbon-containing extracts of petroleum substances.

Kamelia L, de Haan L, Spenkelink B, Bruyneel B, Ketelslegers HB, Boogaard PJ, Rietjens IMCM.

J Appl Toxicol. 2020 Mar;40(3):330-341. doi: 10.1002/jat.3906. Epub 2019 Dec 5.


In vitro metabolism of naphthalene and its alkylated congeners by human and rat liver microsomes via alkyl side chain or aromatic oxidation.

Wang D, Bruyneel B, Kamelia L, Wesseling S, Rietjens IMCM, Boogaard PJ.

Chem Biol Interact. 2020 Jan 5;315:108905. doi: 10.1016/j.cbi.2019.108905. Epub 2019 Nov 23.


A Decoy-Receptor Approach Using Nicotinic Acetylcholine Receptor Mimics Reveals Their Potential as Novel Therapeutics Against Neurotoxic Snakebite.

Albulescu LO, Kazandjian T, Slagboom J, Bruyneel B, Ainsworth S, Alsolaiss J, Wagstaff SC, Whiteley G, Harrison RA, Ulens C, Kool J, Casewell NR.

Front Pharmacol. 2019 Jul 30;10:848. doi: 10.3389/fphar.2019.00848. eCollection 2019.


Bioactivity Profiling of Small-Volume Samples by Nano Liquid Chromatography Coupled to Microarray Bioassaying Using High-Resolution Fractionation.

Zietek BM, Still KBM, Jaschusch K, Bruyneel B, Ariese F, Brouwer TJF, Luger M, Limburg RJ, Rosier JC, V Iperen DJ, Casewell NR, Somsen GW, Kool J.

Anal Chem. 2019 Aug 20;91(16):10458-10466. doi: 10.1021/acs.analchem.9b01261. Epub 2019 Aug 2.


Chiral Discrimination of DL-Amino Acids by Trapped Ion Mobility Spectrometry after Derivatization with (+)-1-(9-Fluorenyl)ethyl Chloroformate.

Pérez-Míguez R, Bruyneel B, Castro-Puyana M, Marina ML, Somsen GW, Domínguez-Vega E.

Anal Chem. 2019 Mar 5;91(5):3277-3285. doi: 10.1021/acs.analchem.8b03661. Epub 2019 Feb 12.


Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners.

Ortega Ugalde S, de Koning CP, Wallraven K, Bruyneel B, Vermeulen NPE, Grossmann TN, Bitter W, Commandeur JNM, Vos JC.

Appl Microbiol Biotechnol. 2018 Nov;102(21):9231-9242. doi: 10.1007/s00253-018-9299-4. Epub 2018 Aug 22.


Liquid chromatographic nanofractionation with parallel mass spectrometric detection for the screening of plasmin inhibitors and (metallo)proteinases in snake venoms.

Zietek BM, Mayar M, Slagboom J, Bruyneel B, Vonk FJ, Somsen GW, Casewell NR, Kool J.

Anal Bioanal Chem. 2018 Sep;410(23):5751-5763. doi: 10.1007/s00216-018-1253-x. Epub 2018 Aug 9.


Rapid ligand fishing for identification of acetylcholinesterase-binding peptides in snake venom reveals new properties of dendrotoxins.

Vanzolini KL, Ainsworth S, Bruyneel B, Herzig V, Seraus MGL, Somsen GW, Casewell NR, Cass QB, Kool J.

Toxicon. 2018 Sep 15;152:1-8. doi: 10.1016/j.toxicon.2018.06.080. Epub 2018 Jul 7.


Nanofractionation Platform with Parallel Mass Spectrometry for Identification of CYP1A2 Inhibitors in Metabolic Mixtures.

Zietek BM, Mladic M, Bruyneel B, Niessen WMA, Honing M, Somsen GW, Kool J.

SLAS Discov. 2018 Mar;23(3):283-293. doi: 10.1177/2472555217746323. Epub 2017 Dec 21.


Analytical workflow for rapid screening and purification of bioactives from venom proteomes.

Otvos RA, Heus F, Vonk FJ, Halff J, Bruyneel B, Paliukhovich I, Smit AB, Niessen WM, Kool J.

Toxicon. 2013 Dec 15;76:270-81. doi: 10.1016/j.toxicon.2013.10.013. Epub 2013 Oct 16.


An efficient analytical platform for on-line microfluidic profiling of neuroactive snake venoms towards nicotinic receptor affinity.

Heus F, Vonk F, Otvos RA, Bruyneel B, Smit AB, Lingeman H, Richardson M, Niessen WM, Kool J.

Toxicon. 2013 Jan;61:112-24. doi: 10.1016/j.toxicon.2012.11.002. Epub 2012 Nov 14.


Online fluorescence enhancement assay for the acetylcholine binding protein with parallel mass spectrometric identification.

Kool J, de Kloe GE, Bruyneel B, de Vlieger JS, Retra K, Wijtmans M, van Elk R, Smit AB, Leurs R, Lingeman H, de Esch IJ, Irth H.

J Med Chem. 2010 Jun 24;53(12):4720-30. doi: 10.1021/jm100230k.


Determination of Flavonoids and Resveratrol in Wine by Turbulent-Flow Chromatography-LC-MS.

Presta MA, Bruyneel B, Zanella R, Kool J, Krabbe JG, Lingeman H.

Chromatographia. 2009 Jun;69(Suppl 2):167-173. Epub 2009 May 26.


High-performance liquid chromatography-mass spectrometry-based acetylcholinesterase assay for the screening of inhibitors in natural extracts.

de Jong CF, Derks RJ, Bruyneel B, Niessen W, Irth H.

J Chromatogr A. 2006 Apr 21;1112(1-2):303-10. Epub 2006 Mar 3.


A microfluidic-based enzymatic assay for bioactivity screening combined with capillary liquid chromatography and mass spectrometry.

de Boer AR, Bruyneel B, Krabbe JG, Lingeman H, Niessen WM, Irth H.

Lab Chip. 2005 Nov;5(11):1286-92. Epub 2005 Sep 22.


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